DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hop and hck

DIOPT Version :9

Sequence 1:NP_511119.2 Gene:hop / 32080 FlyBaseID:FBgn0004864 Length:1177 Species:Drosophila melanogaster
Sequence 2:XP_005174178.1 Gene:hck / 101885596 ZFINID:ZDB-GENE-090313-72 Length:499 Species:Danio rerio


Alignment Length:519 Identity:132/519 - (25%)
Similarity:207/519 - (39%) Gaps:116/519 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   695 EDNKIIHNYIR----------------------CSNLYVTKYDPNSYVLDAKISDPGYP-----R 732
            :||:.:.:|.:                      ..|:.:..||..:    ....|.|:.     |
Zfish    20 DDNRNVAHYTKDPTTGAKANRTTSNAQTPGTDTSENIAIALYDYEA----MHEGDLGFKKGDRLR 80

  Fly   733 PYRESDSPW------------IPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQE 785
            ..:||...|            ||..|     .||.....:.|.|...       .::|    .:.
Zfish    81 ILQESGEWWKAVIISTGQEGFIPSNY-----VAKDTLETEEWFFKGV-------SRKD----AER 129

  Fly   786 QLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPN--YMP 848
            |||...|..|:.: :.|.:........::.|  ||.:.....|:         |...|.|  :..
Zfish   130 QLLASGNKTGSFM-IRDSETTKGSYSLSVRD--SDHQADTVKHY---------KIRTLDNGGFYI 182

  Fly   849 PPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSEC-----------------RVIYNMEN 896
            .|.|..|...|  ::..       :.:.:..:...|||.|                 |....::.
Zfish   183 SPRITFNTLQD--LVSH-------YKKQSDGLCQSLTSPCLSPKPQKPWEKDAWEIPRESLKLDK 238

  Fly   897 MIGRGHYGTVYKGHLEFNDKDQPREQVAIKMLNTMQVSTD-FHREIGIMRTLSHPNIVKFKYWAE 960
            .:|.|.:|.|:......:.|      ||:|.:....:|.: |..|..:|::|.|..:|:......
Zfish   239 RLGAGQFGEVWMAMYNKHTK------VAVKTMKPGSMSVEAFLMEANLMKSLQHDKLVRLNAVVT 297

  Fly   961 KSH--CIIMEYLQSGSFDIYLRFTAPN-LNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILV 1022
            |..  .||.|:::.||...:::....| :..|:|:.|:..||.||.|:.....|||||.|.||||
Zfish   298 KEEPIYIITEFMEKGSLLDFIKSDEGNRVQLPKLIDFSAQIAEGMAYIEQRNYIHRDLRAANILV 362

  Fly  1023 DHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEM 1087
              |....| ||:|||||:.. .|..|.|:.....||:|.:||||:...|:..|||||:|:.|.|:
Zfish   363 --NKSLVC-KIADFGLARII-EDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDVWSFGILLTEI 423

  Fly  1088 FSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDII 1151
            .|.|..|  .|..|:.| .:..|:.|.|:.|..|||..:||:|..||...|..||:|..:..::
Zfish   424 ISYGRTP--YPGMTNPE-VIRALERGYRMQRLDSCPQELYDIMLECWKNKPEDRPTFEYLQSVL 484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hopNP_511119.2 B41 39..259 CDD:214604
SH2_Jak_family 420..516 CDD:198177
PTK_Jak_rpt1 584..836 CDD:270633 30/179 (17%)
PTKc_Jak_rpt2 886..1155 CDD:270634 93/287 (32%)
TyrKc 894..1151 CDD:197581 90/260 (35%)
hckXP_005174178.1 SH3 58..109 CDD:302595 11/59 (19%)
SH2 113..215 CDD:301589 24/133 (18%)
PTKc_Hck 222..487 CDD:270658 91/276 (33%)
Pkinase_Tyr 234..484 CDD:285015 90/262 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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