DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hop and tyk2

DIOPT Version :9

Sequence 1:NP_511119.2 Gene:hop / 32080 FlyBaseID:FBgn0004864 Length:1177 Species:Drosophila melanogaster
Sequence 2:XP_003198201.2 Gene:tyk2 / 100536675 ZFINID:ZDB-GENE-071116-4 Length:1165 Species:Danio rerio


Alignment Length:1307 Identity:303/1307 - (23%)
Similarity:508/1307 - (38%) Gaps:319/1307 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 SLRSGTS-SQS----IH-----TNDGTIRVFNFTTGEFERFHPNMLCEEICNTMCRQLGIAPIAQ 85
            |.::||| .||    :|     |.||. |..::..||       :..|::.....:.:||.|:..
Zfish    11 SKKAGTSKGQSEGPGVHVFLFWTKDGE-RCLSYKKGE-------VTAEDLTTEAAKAVGITPVCH 67

  Fly    86 LLYGIREHSTSRRPSPLVRLDLTWCLPGERLNCQ----LVYCFRMRF----------RVPEL--- 133
            .|:.:.:.::           |.|..|....|.:    |:..||:||          ..||:   
Zfish    68 ALFALYDPAS-----------LCWYSPNHNFNAENQSGLLLHFRLRFYFHKWHGLGENAPEVGRY 121

  Fly   134 ---------DSQLELIDGRSHKFLYRQMRYDMRTEQIP------EIRYPEHKDKSTGLAVMDMLI 183
                     .:...|::..:.::|:.|.:||...:.:|      |.....::::..|:||:.:..
Zfish   122 ALRTSAGTQQATSHLLELSALEYLFAQAKYDFVNDLVPLNAVSGEEEIGRYQNECLGMAVLHLSY 186

  Fly   184 DD-------QEQSEDQQAMRSIEKLYKLYLPPSLWRAHSFFVGSKIREVF---------RSLKAN 232
            ..       |:.::....:|.|...:..::     ...:.....:||.||         .::...
Zfish   187 TALQTGSSLQDVAKQTSFLRCIPLSFSRHI-----AKQNILTRFRIRRVFAHFVNTFQQHTVGVG 246

  Fly   233 SLSVERLKWHYVHQVSHLAPTYMTEQFTCTVQYLPNEEVARGSGPIGTSLAHSTSTLASSGSTN- 296
            .|..:.:.:.|:..:..|||.:..|.|  .|.:|.    .|..|      ..|.|.|.:|.:.| 
Zfish   247 KLGSQEVMYKYLSTLERLAPHFGVETF--PVFHLD----LRADG------GDSGSYLITSRTQNP 299

  Fly   297 TLSTLTTNTNSVALGGSG-----KKAKRRSTSGGIDVYVRVFPHDSLEPGLKVARVTSEATLKW- 355
            ...|:...|:.:.:.||.     |.:.:||.|   |.|       |.....:.|.:..|.  .| 
Zfish   300 PEETINEPTHEIRVSGSDGIWWRKFSAQRSQS---DDY-------SHSQNKETAALNEEE--DWN 352

  Fly   356 -------ILVGAVEGI-FMISKINDTSVRLEIVGLPKGYEMQFQTEKEMKSFISYLGIYIRLSSK 412
                   |.:.|::|| ..||:.::.|:           ::...:..:.:|.:|.|..|.||::.
Zfish   353 IFCDFPEISLIAIQGINVCISRQDNMSM-----------DISLDSSIQARSLVSLLDGYFRLTTD 406

  Fly   413 WMQDLCHSYRTPSLEELSSLHCHGPIGGAYSLMKLHENGDKCGSYIVRECDREYNIYYIDINTKI 477
            ....||.....|.:....|...|||:...:.|.||....:: |:::||....:|:..   |...:
Zfish   407 AHHYLCREVAPPRVVLSESNDLHGPLMDEFVLQKLKREVEE-GAFLVRWSALDYHRI---ILASL 467

  Fly   478 MAKKTDQERCKTETFRIVRKDS-----QWKLSYNNGEHVLNSLHEVAHIIQADSPDRYRIPASKY 537
            ...|.:.|....:.|||.:..|     .|...:::.:.:.:||..   .:.....|.:.:.....
Zfish   468 SRSKKEGENPVYKQFRIRQNGSLFHLEGWDQDFSSIKELTSSLKT---FVLKSGEDSFTLKKCCL 529

  Fly   538 DKPPLL--LLLLPKNLKAKKTDLQLSEAELQRRNPQIFNP----------------RTDLQ--WY 582
            .||..|  ||::.|..|:...    |.:|....:...|||                ||::.  |.
Zfish   530 PKPGELSNLLIIRKGAKSSIK----SASETPDLSKLSFNPIKDKEITKEQHLGRGTRTNIYSGWL 590

  Fly   583 PDSISLSDDGMMFTMRGDWIQQS-----PVKDVSVTMKMLKSD--GNFMEFFRLAQTWSLIQSPQ 640
            ....||.|:.          .:|     ..|.:.|.:|:|:..  ...:.||..|...|.:....
Zfish   591 KIRGSLEDED----------DESNNNHCKTKGIRVVLKILEQSQKDKALAFFETASLMSQVSHCH 645

  Fly   641 FLKLYGLTL-ADPYTMVMEYSRYGPLNKFLH-SMPNVTLHCLLDLMHGLVRGMHYLEDNKIIHNY 703
            .:.::||:: .....||.|:..:|||:.||| ...:|:......:...|...:.|||..:::|..
Zfish   646 LIFVHGLSVKGTENIMVEEFVEFGPLDVFLHRERAHVSPQWKFTVAKQLASALCYLETKRLVHGN 710

  Fly   704 IRCSNLYVTK----YDPNSYVLDAKISDPG-----YPRPYRESDSPWIPVKYYRNLQAAKTDQFA 759
            :...|:.|.:    ...:.:|   |:||||     ..:..|....|||..:...:  ..:....|
Zfish   711 VCGKNILVVRKGLEEGTSPFV---KLSDPGISLSALSQGERVERIPWIAPECVAD--GTRIGSAA 770

  Fly   760 QLWAFATTIYEIFSRCKE-DL----STLRQEQLLRQ----------KNLDGNILKMLDQDICPAP 809
            ..|:|..|:.||   |.. ||    |||.::|...:          :.|...|.:.|..|....|
Zfish   771 DKWSFGATLLEI---CNNGDLHVSNSTLSEKQRFYETQSRLAVPSSQELASFISRCLTYDAAARP 832

  Fly   810 IFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFP 874
            .|.||:...::.:.|   :.||.|     :.|.||:            .|.:|..:         
Zfish   833 SFRTILRELTEIQIK---NPDISS-----ECESLPD------------KDPSVFYK--------- 868

  Fly   875 RSNMLMVIPLTSECRVIYNMENMIGRGHYGT----VYKGHLEFNDKDQPREQVAIKMLNTMQVST 935
                          |.:..:.: :|.||:|.    ||..|     .|...|.||:|.|......:
Zfish   869 --------------RYLRKIRD-LGEGHFGKVMLYVYDPH-----NDGTGEYVAVKALKQEGDGS 913

  Fly   936 DFH----REIGIMRTLSHPNIVKFKYWAEKSHC---------IIMEYLQSGSFDIYLRFTAPNLN 987
            ..|    :||.|:::|.|.||||:     |..|         :||||:..||...|:......:.
Zfish   914 SLHVSWMKEIEILKSLYHNNIVKY-----KGCCTEMGGQVVQLIMEYVPLGSLREYMPKYGQGIG 973

  Fly   988 NPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQF-ANSDGYYYAK 1051
            ...|  ||..|..||.||.....|||||||||:|:::.|   .|||.||||.:: ...|.||..:
Zfish   974 QGLL--FAQQICLGMDYLHSKRYIHRDLAARNVLLENEG---VVKIGDFGLTKYIPEGDIYYRVR 1033

  Fly  1052 SKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFS----RGEEPN-------LVPIQTSQED 1105
            ...|.|:.||:.|.:...:||..|||||:.|||:|:.:    |...|:       .|..|.:...
Zfish  1034 EDGDSPVFWYAIECLKESKFSFASDVWSFAVTLYEILTNCSHRLSPPSKFSDMMGTVHGQMTVVK 1098

  Fly  1106 FLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIVDIITREVATKVTHPTDGHQSPP 1170
            .::.|:..|||..|..||..:|.||:.||...|..||||.::.:.: .|:           :.|.
Zfish  1099 LISLLEKNERLPCPPGCPREVYSLMEQCWDFNPDQRPSFLSLAESL-EEI-----------RGPY 1151

  Fly  1171 NQPTDAE 1177
            .||:..:
Zfish  1152 KQPSSLQ 1158

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hopNP_511119.2 B41 39..259 CDD:214604 48/276 (17%)
SH2_Jak_family 420..516 CDD:198177 21/100 (21%)
PTK_Jak_rpt1 584..836 CDD:270633 66/284 (23%)
PTKc_Jak_rpt2 886..1155 CDD:270634 99/297 (33%)
TyrKc 894..1151 CDD:197581 98/285 (34%)
tyk2XP_003198201.2 B41 46..273 CDD:214604 40/249 (16%)
FERM_C_TYK2 268..414 CDD:275414 40/180 (22%)
SH2 414..511 CDD:301589 21/100 (21%)
PKc_like 571..842 CDD:304357 65/288 (23%)
Pkinase_Tyr 571..841 CDD:285015 65/287 (23%)
PKc_like 866..1147 CDD:304357 99/320 (31%)
Pkinase_Tyr 871..1144 CDD:285015 98/288 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 247 1.000 Inparanoid score I3244
OMA 1 1.010 - - QHG47769
OrthoDB 1 1.010 - - D38412at33208
OrthoFinder 1 1.000 - - FOG0001105
OrthoInspector 1 1.000 - - otm26318
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45807
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X669
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
99.080

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