DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and srms

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	NP_001129722.2	Gene:	srms / 100192213	ZFINID:	ZDB-GENE-081022-95	Length:	492	Species:	Danio rerio

Alignment Length:	488	Identity:	139/488 - (28%)
Similarity:	209/488 - (42%)	Gaps:	113/488 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   730 YPRPYRESDSPWIPVKYYRNLQA-----AKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQL-- 787
            ||..:|..|        .|.:..     |...:.|||:|   .:::..:|.:|:||....::|
Zfish    24 YPNLHRPDD--------IRTVSGDIRVPAPKKKPAQLYA---ALFDFVARSEEELSVKEGDKLSV 77

  Fly   788 -------LRQKNLDGNILKMLDQDICPAPIFETIMD-----GW----------------SDDETK 824
                   :..|.|.|:    |:..:.||.....:.|     .|                |:::|.
Zfish    78 IEKRGDYVFAKKLTGS----LESGLIPANYVALLKDEFANYKWYYGNINRQKAEKLLLSSENKTG 138

  Fly   825 RF------SHHDIFSRLNTIKAEI-------------LPNYMPPPEIATNGTGDETVIDRSDIPF 870
            .|      ||.|.:    ||.|..             :..|....:|:. ||.||.:
Zfish   139 SFLVRISESHSDEY----TISARSENSVFHFRIHRSPIGAYFVSEKISF-GTLDELI-------- 190

  Fly   871 LPFPRSNMLMVIPLTSEC---RVIYNME------------NMIGRGHYGTVYKGHLEFNDKDQPR 920
            ..:.:::..:...:...|   |.:::||            ..:|.||:|.|::...:...|
Zfish   191 RYYQQNSRSLGCHIDQPCVQRRELFDMEPWERPREEFMLVKKLGEGHFGEVWEAIWKTQKK---- 251

  Fly   921 EQVAIKMLNTMQVSTD-FHREIGIMRTLSHPNIVKFKYWAEKSH--CIIMEYLQSGSFDIYLRFT 982
             :||||||.......| |.:|:..::.|.||.:::......:..  .|:.|.:..||...||...
Zfish   252 -KVAIKMLKQEDTKLDEFVKEVHALKNLHHPKLIELLALCSRGEPVYIVTELMAKGSLKSYLSSA 315

  Fly   983 APN-LNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFANSDG 1046
            ... |.:..|:..|..||.||.||.|..::|||||||||||   |:....|::|||||:.. .|.
Zfish   316 EGQLLTSAHLIYMAAQIAEGMAYLEDRHIVHRDLAARNILV---GNDLVCKVADFGLARII-KDS 376

  Fly  1047 YYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQ 1111
            .:.|.....||:||.:|||....|||..|||||:||.|:||.|||:.|  ...:|::| .:..|.
Zfish   377 VFTASKTTKIPVRWTAPEAALYQRFSVKSDVWSFGVLLYEMMSRGKMP--YDGKTNKE-VMEALS 438

  Fly  1112 SGERLNRPASCPDFIYDLMQLCWHATPRSRPSF 1144
            ||.||..|..||..||.:|..||:.....||||
Zfish   439 SGYRLACPNHCPPNIYRIMLECWNNEASKRPSF 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	29/146 (20%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	101/278 (36%)
		TyrKc	894..1151	CDD:197581	99/267 (37%)
srms	NP_001129722.2	SH3	52..106	CDD:302595	13/60 (22%)
		SH2	114..197	CDD:214585	16/95 (17%)
		PKc_like	220..481	CDD:304357	97/264 (37%)
		STYKc	229..478	CDD:214568	97/255 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810