DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hop and jak1

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	XP_002931642.1	Gene:	jak1 / 100038172	XenbaseID:	XB-GENE-483750	Length:	1142	Species:	Xenopus tropicalis

Alignment Length:	1223	Identity:	293/1223 - (23%)
Similarity:	466/1223 - (38%)	Gaps:	260/1223 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 GEFERFHPNMLCEEICNTMCRQLGIAPIAQLLYGI-REHSTSRRPSPLVRLDLTWCLPGERL--- 116
            |||       ..|::|........|:|:...|:.: .|.|.|            |..|....
Frog    40 GEF-------TAEDLCIESALHCNISPLCHNLFALYNERSQS------------WYSPNHNFKID 85

  Fly   117 -NCQLVYCFRMRF-----------------RVP---------ELDSQLELIDGRSHKFLYRQMRY 154
             |..|...:||||                 ..|         ::.....|:|..|..:|:.|.:|
Frog    86 SNVSLKLHYRMRFIFTNWHGTNENEPSVWRHYPKKRDGYDKKQIQEGTPLLDASSLDYLFAQGQY 150

  Fly   155 DMRTEQIPEIRYP-------EHKDKSTGLAVMDMLIDDQEQSEDQQAMRSIEK-------LYKLY 205
            :: .:.:..:|.|       |.:::..|:||:.:        ......|:|:.       .||.|
Frog   151 EL-VKCLAPVREPKNDQEVHEIENECLGMAVLAI--------SHYAIKRNIQLPDLPKDISYKKY 206

  Fly   206 LPPSLWRA---HSFFVGSKIREVFRS-LKA--------NSLSVERLKWHYVHQVSHLAPTYMTEQ 258
            :|.:|.|.   .:|....:|..||:: ||.        :|:|...||..|:..:..|...|..|.
Frog   207 IPETLNRTIKQRNFLTRMRINNVFKNFLKEFNNKTICDSSVSPHDLKVKYLSTMETLTKNYGAES 271

  Fly   259 FTCTVQYLPNEEVARGSGPIGTSLAHSTSTLASSGSTNTLSTLTTNTNSVALGGSGKKAKRRSTS 323
            |......:.:|....|            ..::...|......|.|       |.||.:.:|:.|.
Frog   272 FETNSLIIKSENEQNG------------FNISDYDSMRRYEVLVT-------GNSGIQWRRKPTC 317

  Fly   324 GGIDVYVRVFPHDSLEPGLKVARVTSEATLK-----------WILVGAVEGIFMISKINDTSVRL 377
                        .:.|...|:.|..:|:..|           |........|..|:...||
Frog   318 ------------TTSEKDRKLKRKKTESKSKNSDEKGKLKDEWNCFSYYPEITHIAIKEDT---- 366

  Fly   378 EIVGLP--KGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEELSSLHCHGPIGG 440
            .|:...  |..|::..:::|..||.:.:..|.||::.....||.....|.:.......|||||..
Frog   367 VIINNQDNKSMELKLSSQEEALSFAALIDGYFRLTADAHHYLCSDVAPPLIVNNIKNGCHGPICT 431

  Fly   441 AYSLMKLHENGDKCGSYIVRECDREYNIYYIDINTKIMAKKTDQERCKTETFRI-VRKDSQWKLS 504
            .|::.||.:.|::.|.|::|....::|...:.::...|::...:...:.:.|:| |:|.....|.
Frog   432 EYAINKLRQEGNEEGMYVLRWSCTDFNNILMTVSCSKMSQFESKYVKQYKNFQIEVKKGRYSLLG 496

  Fly   505 YNNGEHVLNSL--HEVAHIIQADSPDRYRIPASKYDKPPLLLLLLPKNLKAKKTD--LQLSEAEL 565
            .:.|...|..|  |....:::.|... :.:......||..:..||....||.:..  ..||:...
Frog   497 PDRGFDSLKDLMKHLKGQVLKTDDVS-FTLKKCCPPKPREISNLLVATKKALEWQPVYHLSQLSF 560

  Fly   566 QR------RNPQIFNPRTDLQWYPDSISLSDDGMMFTMRGDWIQQSPVKDVSVTMKMLKSDGN-- 622
            .|      ...:.....|..|.|...::..||       .|....|..|::.|.:|:|.....
Frog   561 HRILKEEITQLEHLGRGTRTQIYAGKLNYKDD-------NDSESYSTEKEIKVILKVLDPSHRDI 618

  Fly   623 FMEFFRLAQTWSLIQSPQFLKLYGLTLAD-PYTMVMEYSRYGPLNKFLHSMPNV-TLHCLLDLMH 685
            .:.||..|.....:.....:.|:|:.:.| ...||.|:..:|||:.|:|....| |......:..
Frog   619 SLAFFETASMMRQVSHKHIVLLHGVCVRDVENIMVEEFVDFGPLDLFMHRKSEVLTTPWKFKVAK 683

  Fly   686 GLVRGMHYLEDNKIIHNYIRCSNLYVTK----YDPNSYVLDAKISDPGYP-----RPYRESDSPW 741
            .|...:.||||..::|..:...|:.:.:    .|...::   |:||||.|     |..|....||
Frog   684 QLASALSYLEDKDLVHGNVCTKNILLAREGIDNDCGPFI---KLSDPGIPITVLTRQERVERIPW 745

  Fly   742 IP---VKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGN------- 796
            |.   |:..|.|..|     |..|:|.||::||   |......|:...|..::...|.
Frog   746 IAPECVEDSRVLSVA-----ADKWSFGTTLWEI---CFNGEVPLKDRTLAEKERFYGGCFMLVAP 802

  Fly   797 --------ILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAEILPNYMPPPEIA 853
                    |.:.::.|....|.|..||             .:| ::|.....:|:....|..|:
Frog   803 SCKELADLINQCMNYDPLRRPFFRAIM-------------REI-NKLEEQNPDIVSEKTPSAEV- 852

  Fly   854 TNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQ 918
                 |.|:.::.   ||...|.                     :|.||:|.|.....: .:.|.
Frog   853 -----DPTLFEKR---FLKRVRD---------------------LGEGHFGKVELCRYD-PEGDN 887

  Fly   919 PREQVAIKMLNTMQVST---DFHREIGIMRTLSHPNIVKFKYWAEKSHC---IIMEYLQSGSFDI 977
            ..|.||:|.|......:   |..:||.|:|.|.|.||||:|...|....   :|||||.|||...
Frog   888 TGELVAVKSLKPGTAGSHIADLKKEIEILRNLYHENIVKYKGICEDGGSGIKLIMEYLPSGSLKE 952

  Fly   978 YLRFTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFA 1042
            ||......:|..:.:.:|..|..||.||.....:||||||||:||::.   ..:||.||||.:..
Frog   953 YLPRNVNKINLKQQLKYATQICKGMDYLGSRQYVHRDLAARNVLVENE---QIIKIGDFGLTKAI 1014

  Fly  1043 NSD-GYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEM--FSRGEEPNLVPI----- 1099
            .:| .||..|...|.|:.||:||.:..|:|...|||||:||||:|:  :...|...:...
Frog  1015 ETDKEYYTVKDDLDSPVFWYAPECLLHCKFYIASDVWSFGVTLYELLTYCNSEYSPMTMFLKMIG 1079

  Fly  1100 ----QTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATIV 1148
                |.:....:..|:..:||..||:||..:|.||..||...|..|.:|..::
Frog  1080 PTQGQMTVTRLVRVLEEDKRLPIPANCPKQVYQLMLKCWEQNPSHRTTFQDLI 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604	54/259 (21%)
		SH2_Jak_family	420..516	CDD:198177	23/98 (23%)
		PTK_Jak_rpt1	584..836	CDD:270633	65/282 (23%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	96/281 (34%)
		TyrKc	894..1151	CDD:197581	96/273 (35%)
jak1	XP_002931642.1	FERM_F1	23..116	CDD:375805	19/94 (20%)
		FERM_F2	133..263	CDD:375803	31/138 (22%)
		FERM_C_JAK1	268..411	CDD:275412	33/177 (19%)
		SH2_Jak1	411..512	CDD:198241	24/100 (24%)
		PTK_Jak1_rpt1	568..833	CDD:270662	68/296 (23%)
		PTKc_Jak1_rpt2	857..1139	CDD:173644	99/304 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3289
OMA	1	1.010	-	-		QHG47769
OrthoDB	1	1.010	-	-		D38412at33208
OrthoFinder	1	1.000	-	-		FOG0001105
OrthoInspector	1	1.000	-	-		otm47699
Panther	1	1.100	-	-	O	PTHR45807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X669
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.080