DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hop and abl1

DIOPT Version :9

Sequence 1:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster
Sequence 2:	XP_005172104.1	Gene:	abl1 / 100000720	ZFINID:	ZDB-GENE-100812-9	Length:	1081	Species:	Danio rerio

Alignment Length:	391	Identity:	119/391 - (30%)
Similarity:	185/391 - (47%)	Gaps:	73/391 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   833 SRLNTIKAEILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSEC------RVI 891
            ||.||: ||::.::      :|...|..|.:      ..|.|:.|...:..::...      |..
Zfish   204 SRFNTL-AELVHHH------STVSDGLITTL------HYPAPKRNKPTIYGVSPNYDKWEMERTD 255

  Fly   892 YNMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKML--NTMQVSTDFHREIGIMRTLSHPNIVK 954
            ..|::.:|.|.||.||:|..:     :....||:|.|  :||:|. :|.:|..:|:.:.|||:|:
Zfish   256 ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLKEDTMEVE-EFLKEAAVMKEIKHPNLVQ 314

  Fly   955 F--KYWAEKSHCIIMEYLQSGSFDIYLR-FTAPNLNNPRLVSFALDIANGMKYLSDMGLIHRDLA 1016
            .  ....|....||.|::..|:...||| .....:|...|:..|..|::.|:||.....||||||
Zfish   315 LLGVCTREPPFYIITEFMTHGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLA 379

  Fly  1017 ARNILVDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYG 1081
            |||.||   |:.:.||::||||::....| .|.|.:....||:|.:||:::..:||..||||::|
Zfish   380 ARNCLV---GENNLVKVADFGLSRLMTGD-TYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFG 440

  Fly  1082 VTLFEMFSRGEEPNLVP-IQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFA 1145
            |.|:|:.:.|..|  .| |..||  ....|:...|::||..||:.:|:||:.||...|..|||||
Zfish   441 VLLWEIATYGMSP--YPGIDLSQ--VYELLEKDYRMDRPEGCPEKVYELMRACWRWNPAERPSFA 501

  Fly  1146 -------------TIVDIITREVATK---------------------VTHPTDGHQSPPNQPTDA 1176
                         :|.|.:.:|:..|                     :..||||.........:|
Zfish   502 ETHQAFETMFQESSISDEVEKELGKKGKKLTLGPIQQAPELPTKTRTLRRPTDGRDGDSPDAAEA 566

  Fly  1177 E 1177
            |
Zfish   567 E 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	2/2 (100%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	99/293 (34%)
		TyrKc	894..1151	CDD:197581	98/275 (36%)
abl1	XP_005172104.1	SH3_Abl	79..132	CDD:212784
		SH2_ABL	137..230	CDD:198189	9/38 (24%)
		PTKc_Abl	249..511	CDD:270645	97/275 (35%)
		Pkinase_Tyr	256..507	CDD:285015	96/264 (36%)
		FABD	958..1081	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910