DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dsh and DIXDC1

DIOPT Version :9

Sequence 1:	NP_511118.2	Gene:	dsh / 32078	FlyBaseID:	FBgn0000499	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001033043.1	Gene:	DIXDC1 / 85458	HGNCID:	23695	Length:	683	Species:	Homo sapiens

Alignment Length:	84	Identity:	35/84 - (41%)
Similarity:	55/84 - (65%)	Gaps:	1/84 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDSTI 75
            |||:|..|...||::|.||....:|||:|||..:::: .|::|.||::|.:||.|||||..|...
Human   601 TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDRE-GNHRYHFKALDPEFGTVKEEIFHDDDA 664

  Fly    76 LPCFNGRVVSWLVSADGTN 94
            :|.:.|::|:|:....|.|
Human   665 IPGWEGKIVAWVEEDHGEN 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	33/79 (42%)
		Dishevelled	<166..248	CDD:280528
		PDZ_signaling	250..337	CDD:238492
		DEP_dishevelled	395..478	CDD:239885
DIXDC1	NP_001033043.1	CH_DIXDC1	22..128	CDD:409062
		Actin-binding	127..300
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..235
		Smc	<281..>463	CDD:224117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..509
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..594
		DIX	600..677	CDD:395628	33/76 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150915
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930