Protein Alignment dsh and dvl3a

DIOPT Version :10

• Sequence 1: NP_511118.2
• Gene: dsh / 32078
• FlyBaseID: FBgn0000499
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_571832.2
• Gene: dvl3a / 80972
• ZFINID: ZDB-GENE-010319-1
• Length: 676
• Species: Danio rerio
• Alignment Length: 662
• Identity: 288/662 - (43%)
• Similarity: 379/662 - (57%)
• Gaps: 132/662 - (19%)

  Fly    10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDST 74
            |||||||:||:.||||||:|||:.:|||.|.|..|.|.  |||:||||||.|||||||||.||:.
Zfish     3 ETKVIYHLDDQETPYLVKLPIPAERVTLLDLKNALKKP--NYKFFFKSMDDDFGVVKEEITDDNA 65

  Fly    75 ILPCFNGRVVSWLVSADGTNQSDNC------SELPTSECELGMGLTNRK---------------- 117
            .|||:||||:.||||:||:: ||.|      ||.|.|. |...|:.:.:
Zfish    66 KLPCYNGRVICWLVSSDGSH-SDGCSVAESQSERPPSH-ERSQGIGDSRPPSFHPKAAGSRHGVD 128

  Fly   118 -------LQQQQQQHQQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLHHQKMMGNPL-LQP 174
                   :...::...:.:.:::..|:....:|                  :.....|..: |..
Zfish   129 DETETDSVVSHRRDRDRDRSRRKHSHEHSGGKQ------------------NGYSRGGRGMDLGG 175

  Fly   175 PPLTYQSASVLSSDLDSTSLF----GTESELTLDRDMTDYSSVQRLQVRK-KPQRRKKRAPSMSR 234
            ..:....:|::||:|:|:|.|    |:.|..:   .:|:.|...:|..:| :.:|||.||..|.|
Zfish   176 YDICDSRSSLMSSELESSSCFDSDDGSTSRFS---SVTEQSGSSKLMTKKPRRRRRKTRAQQMER 237

  Fly   235 TSSYSSITDSTMSLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPG 299
            :||:|||||||||||||||::|||..||||||||||||..||||||:||||||||||.|||||||
Zfish   238 SSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPG 302

  Fly   300 DMILQVNDVNFENMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAW 364
            ||:|||||:|||||.||:|||||||:|.||||:.|.|||||||||...|.:||:||:|||||.||
Zfish   303 DMLLQVNDINFENMCNDDAVRVLREIVHKPGPVSLTVAKCWDPNPNSCFALPRSEPIRPIDPAAW 367

  Fly   365 VAHTQALT-----------------SHDSIIADIAEPIKERLD------QNNLEEIVKAMTKPDS 406
            |:||.|:|                 :..||.:.|  |..||.|      .:::..:.|||..|||
Zfish   368 VSHTAAMTGVYPPYGMSPSMSTVTSTSSSISSSI--PETERFDDYHLSVHSDMATVAKAMACPDS 430

  Fly   407 GLEIRDRMWLKITIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQ 471
            |||:||||||||||.|||||:|.|:|:..:||...||||||:..|.:|::.:|:|||||:|||||
Zfish   431 GLEVRDRMWLKITIANAFIGSDVVDWLFHHVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQ 495

  Fly   472 CYYVVNEERNPNLLGR-GHLHPHQLPHGHGGHALSHADTESITSDIGPLPNPPIYMPYSATYNPS 535
            |||:..:     |.|. .||   .|....|....|..||      :.||.: |...|:.|.:
Zfish   496 CYYIFGD-----LSGNMAHL---SLQDHDGSSGASDQDT------LAPLLH-PAEAPWPAAF--- 542

  Fly   536 HGYQPIQYGIAERHI------SSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAHGSNKSSG 594
                |.||..|..|:      |:||..|:..:..:.|.|:::                  .|::.
Zfish   543 ----PYQYPAAHSHLEEAGGGSAGSQQSEGSSGSNCSWSRTE------------------GKTAA 585

  Fly   595 SSNRGGGGGGGG 606
            ...|.|||...|
Zfish   586 GDFRLGGGSEMG 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	56/80 (70%)
		Dishevelled	<174..248	CDD:460544	30/78 (38%)
		PDZ_Dishevelled-like	252..338	CDD:467201	68/85 (80%)
		DEP_dishevelled	395..478	CDD:239885	51/82 (62%)
dvl3a	NP_571832.2	DAX	1..82	CDD:197474	56/80 (70%)
		Dishevelled	87..251	CDD:460544	42/185 (23%)
		PDZ_Dishevelled-like	255..341	CDD:467201	68/85 (80%)
		DEP_dishevelled	419..502	CDD:239885	51/82 (62%)
		Dsh_C	506..669	CDD:463531	29/127 (23%)