DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsh and dvl2

DIOPT Version :9

Sequence 1:	NP_511118.2	Gene:	dsh / 32078	FlyBaseID:	FBgn0000499	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001072660.1	Gene:	dvl2 / 780117	XenbaseID:	XB-GENE-1017461	Length:	732	Species:	Xenopus tropicalis

Alignment Length:	662	Identity:	283/662 - (42%)
Similarity:	386/662 - (58%)	Gaps:	101/662 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDST 74
            |||||||:|:|.||||||:|:|:.::.|||||..|.:  .:.|||||:||.|||||||||:||:.
Frog     3 ETKVIYHLDEEETPYLVKVPVPANEIRLRDFKAALGR--GHAKYFFKAMDQDFGVVKEEISDDNA 65

  Fly    75 ILPCFNGRVVSWLVSADGTNQSDNC--------------SELPTSECELGMGLTNRKLQQQQQQH 125
            .||||||||||||||:: |:|:|:.              ..:|....|...|:.:.:........
Frog    66 KLPCFNGRVVSWLVSSE-TSQTDSAPPAAEVRPDPPPVPPPVPPPPAERTSGIGDSRPPSFHPNV 129

  Fly   126 QQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLH---HQKMMGNPLLQPPPLTYQSASVLSS 187
            ....:|..|.::.....::.:|:.....:|...:.::   .:.:.|          |:|:|.|.:
Frog   130 SGSTEQLDQDNESVISMRRDRVRRRDSTEQGVARGVNGRAERHLSG----------YESSSTLLT 184

  Fly   188 DLDSTSLFGTESELTLDR--DMTDYSSVQRLQVRKKPQRRKKRAPSMSRTSSYSSITDSTMSLNI 250
            ....||:..:|.:..:.|  ..|:.||..|| :::..:|||:|.|.:.||||:||:|||||||||
Frog   185 SEIETSICDSEEDDAMSRFSSSTEQSSASRL-LKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNI 248

  Fly   251 ITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMILQVNDVNFENMTN 315
            |||::|||..||||||||||||..||||||:||||||||||.|||||||||:|||||:|||||:|
Frog   249 ITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMSN 313

  Fly   316 DEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHTQAL--------- 371
            |:||||||::|.|||||.|.|||||||:|:||||:||.||::||||.|||:|:.||
Frog   314 DDAVRVLRDIVHKPGPIILTVAKCWDPSPQGYFTLPRNEPIQPIDPAAWVSHSAALSGSFPVYPG 378

  Fly   372 -------TSHDSI----IADIAEPIK--ERLDQNNLEEIVKAMTKPDSGLEIRDRMWLKITIPNA 423
                   ||..|:    ::....|:.  ......:|..:.|.|..|:||||:|||||||||||||
Frog   379 SASMSSMTSSTSVTETELSHALPPVSLFSLSVHTDLASVAKVMASPESGLEVRDRMWLKITIPNA 443

  Fly   424 FIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVVNEERNPNLLG-R 487
            |:|:|.|:|:..:||..|||||||:..|.:|::..|:|||||:||||||||:..:     |.| .
Frog   444 FLGSDMVDWLYHHVEGFQDRREARKFASNLLKAGLIRHTVNKITFSEQCYYIFGD-----LTGCE 503

  Fly   488 GHLHPHQLPHGHGGHALSHADTESITSDIGPLPNP-----PIYMPYSATYNPSHGY--QP----- 540
            .::....|....|....|..||      :.|||.|     |:...:|..|...|.|  ||
Frog   504 NYMANLSLNDNDGSSGASDQDT------LAPLPLPGASPWPLLPTFSYQYPAPHPYSTQPPAYHE 562

  Fly   541 ---IQYGIAERHISSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAHGSNKSSGSSNRGGGG 602
               ..||:.    |:||..|:  .|:...:::||             ...|:.|...|...|.||
Frog   563 LSSYSYGMG----SAGSQHSE--GSRSSGSNRSD-------------GGRGTQKDERSGVVGVGG 608

  Fly   603 GGGGGGNNTNDQ 614
            |....|:.:..:
Frog   609 GESKSGSGSESE 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	55/80 (69%)
		Dishevelled	<166..248	CDD:280528	30/83 (36%)
		PDZ_signaling	250..337	CDD:238492	69/86 (80%)
		DEP_dishevelled	395..478	CDD:239885	50/82 (61%)
dvl2	NP_001072660.1	DAX	1..82	CDD:197474	55/80 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..181		13/110 (12%)
		Dishevelled	112..246	CDD:367060	36/144 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..237		16/42 (38%)
		PDZ_signaling	248..335	CDD:238492	69/86 (80%)
		DEP_dishevelled	415..498	CDD:239885	50/82 (61%)
		Dsh_C	505..722	CDD:372040	33/141 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..660		15/70 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1290
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D224059at33208
OrthoFinder	1	1.000	-	-		FOG0001069
OrthoInspector	1	1.000	-	-		otm47989
Panther	1	1.100	-	-	O	PTHR10878
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4545
SonicParanoid	1	1.000	-	-		X725
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100