Protein Alignment dsh and dvl2

DIOPT Version :10

• Sequence 1: NP_511118.2
• Gene: dsh / 32078
• FlyBaseID: FBgn0000499
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_997813.1
• Gene: dvl2 / 323630
• ZFINID: ZDB-GENE-041118-20
• Length: 747
• Species: Danio rerio
• Alignment Length: 683
• Identity: 302/683 - (44%)
• Similarity: 386/683 - (56%)
• Gaps: 134/683 - (19%)

  Fly    10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDST 74
            |||:|||||:|.|||||||||.:.::||.|||.||||.  |||:||||||.|||||||||:|||.
Zfish     3 ETKIIYHIDEEETPYLVKIPIAAEKITLLDFKQVLNKP--NYKFFFKSMDQDFGVVKEEISDDSA 65

  Fly    75 ILPCFNGRVVSWLVSAD-------------GTNQSDNCSELPTSECELGMGL-----------TN 115
            .||||||||||||||:|             .:..|.....||....|...|:           |.
Zfish    66 KLPCFNGRVVSWLVSSDTPAAEPVAPPVEVPSQPSPPPPPLPPPPAERMAGIGDSRPPSFHPNTT 130

  Fly   116 RKLQQQQQQHQQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLHHQKMMGNPLLQPPPLTYQ 180
            ..|:....|.:.:.....::.:.:.::..:|               |..:|.|...|......|:
Zfish   131 GSLESLDDQTETESVVSFRRERPRPRESLEQ---------------HGPRMNGQSHLDRHLAGYE 180

  Fly   181 SA-SVLSSDLDSTSLFGTESELTLDR--DMTDYSSVQRLQVRKKPQRRKKRAPSMSRTSSYSSIT 242
            || :|:||:||:||...::.:.|:.|  ..|:.|:..||  .|:.:||:|:.|.:.|.||:||:|
Zfish   181 SATTVMSSELDTTSFCDSDDDDTMSRFSSSTEQSTASRL--LKRHRRRRKQRPRLERASSFSSVT 243

  Fly   243 DSTMSLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMILQVND 307
            |||||||||||::|||..||||||||||||..||||||:||||||||||.|||||||||:|||||
Zfish   244 DSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVND 308

  Fly   308 VNFENMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHTQALT 372
            :|||||:||:|||||||:|.|||||.|.|||||||:|:||||:||.||:|||||.|||.|:.|||
Zfish   309 INFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPQGYFTLPRNEPIRPIDPAAWVNHSVALT 373

  Fly   373 S------HDSIIADIAEPIKERLDQNNLE------EIVKAMTKPDSGLEIRDRMWLKITIPNAFI 425
            .      ..:|.:..:....||.|:.||.      .:.|||..|:||||:||||||||||||||:
Zfish   374 GAFPSYPSSTITSSSSVTETERFDEFNLSLRSDMASVAKAMASPESGLEVRDRMWLKITIPNAFL 438

  Fly   426 GADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVVNEERN-PNLLGRGH 489
            |:|.|.|:..:::..|||||||:....:|::.:|:|||||:||||||||:..:..| .|.:....
Zfish   439 GSDVVEWLYHHIDGFQDRREARKYACNLLKAGFIRHTVNKITFSEQCYYIFGDFSNCENYMANLS 503

  Fly   490 LHPHQLPHGHGGHALSHADTESITSDIGPLPNP---PIYMPYSATYNPSHGY--QPIQY------ 543
            |:.:.     |....|..||      :.|||.|   |..:.:|.||...|.|  ||..|
Zfish   504 LNDND-----GSSGASDQDT------LAPLPLPGATPWPLLHSFTYQYPHPYSTQPPPYHELSNY 557

  Fly   544 ----GIAERHISSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAHGSNKSSGSSNRG----- 599
                |.|....|.||.||                              ||.:|.|...||
Zfish   558 SYGPGSAGSQHSEGSHSS------------------------------GSTRSDGEKRRGPKSVS 592

  Fly   600 --------------GGGGGGGGGNNTNDQDVSV 618
                          ||||......:.::.|.||
Zfish   593 ESTVGGSVRDDKSPGGGGADSRSGSGSESDYSV 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	62/80 (78%)
		Dishevelled	<174..248	CDD:460544	31/76 (41%)
		PDZ_Dishevelled-like	252..338	CDD:467201	69/85 (81%)
		DEP_dishevelled	395..478	CDD:239885	48/88 (55%)
dvl2	NP_997813.1	DAX	1..82	CDD:197474	62/80 (78%)
		Dishevelled	112..249	CDD:460544	41/153 (27%)
		PDZ_Dishevelled-like	253..339	CDD:467201	69/85 (81%)
		DEP_dishevelled	408..491	CDD:239885	48/82 (59%)
		Dsh_C	498..737	CDD:463531	38/169 (22%)