DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsh and Dvl3

DIOPT Version :9

Sequence 1:	NP_511118.2	Gene:	dsh / 32078	FlyBaseID:	FBgn0000499	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_006248626.1	Gene:	Dvl3 / 303811	RGDID:	1308834	Length:	718	Species:	Rattus norvegicus

Alignment Length:	671	Identity:	303/671 - (45%)
Similarity:	392/671 - (58%)	Gaps:	135/671 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDST 74
            |||:|||:|.:.||||||:|:|:.:|||.|||.||  |..:||:||||||.|||||||||:||:.
  Rat     3 ETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVL--QRPSYKFFFKSMDDDFGVVKEEISDDNA 65

  Fly    75 ILPCFNGRVVSWLVSADGTNQ------SDNCSELPTSECELG--------------MGLTNRKLQ 119
            .|||||||||||||||:|::.      :||.||||.|....|              .|.:...|.
  Rat    66 KLPCFNGRVVSWLVSAEGSHPEPAPFCADNPSELPPSMERTGGIGDSRPPSFHPHASGGSQENLD 130

  Fly   120 QQQQQHQQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLHHQKMMGNPLLQPPPLTYQSASV 184
            ...:.......|:::..::...:...::......:::::                 |..|.|:|.
  Rat   131 NDTETDSLVSAQRERPRRRDGPEHAARLNGTTKGERRRE-----------------PGGYDSSST 178

  Fly   185 L-SSDLDSTSLFGTESELTLDR--DMTDYSSVQRLQVRKKPQRRKKRAPSMSRTSSYSSITDSTM 246
            | ||:|::||.|.::.:.:..|  ..|:.||..||..|.|.:|||::...:.|:||:||||||||
  Rat   179 LMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTM 243

  Fly   247 SLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMILQVNDVNFE 311
            |||||||::|||..||||||||||||..||||||:||||||||||.|||||||||:||||::|||
  Rat   244 SLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFE 308

  Fly   312 NMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHTQALT---- 372
            ||:||:|||||||:|.|||||.|.|||||||:|:|.||:||:||:|||||.|||:||.|:|
  Rat   309 NMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFP 373

  Fly   373 -------------SHDSIIADIAEPIKERLD------QNNLEEIVKAMTKPDSGLEIRDRMWLKI 418
                         :..||.:.|  |..||||      .:::..|||||..|:||||:||||||||
  Rat   374 AYGMSPSLSTITSTSSSITSSI--PDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKI 436

  Fly   419 TIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVVNE--ERN 481
            ||||||||:|.|:|:..|||...||||||:..|.:|::.:|:|||||:||||||||:..:  ...
  Rat   437 TIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNM 501

  Fly   482 PNLLGRGHLHPHQLPHGHGGHALSHADTESITSDIGPLPNP-----PIYMPYS-----ATYNPSH 536
            .||    .||.|.     |....|..||      :.|||:|     |:..||.     ..|||..
  Rat   502 ANL----SLHDHD-----GSSGASDQDT------LAPLPHPGAAPWPMAFPYQYPPPPHPYNPHP 551

  Fly   537 GYQPIQY----GIAERHISSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAHGSNKSSGSSN 597
            |:..:.|    |.|....|.||.||                              |||: |||..
  Rat   552 GFPELGYSYAGGSASSQHSEGSRSS------------------------------GSNR-SGSDR 585

  Fly   598 R------GGGGGGGGGGNNTN 612
            |      .|....||.|:.::
  Rat   586 RKEKDPKAGDSKSGGSGSESD 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	57/80 (71%)
		Dishevelled	<166..248	CDD:280528	33/84 (39%)
		PDZ_signaling	250..337	CDD:238492	69/86 (80%)
		DEP_dishevelled	395..478	CDD:239885	54/82 (66%)
Dvl3	XP_006248626.1	DAX	1..82	CDD:197474	57/80 (71%)
		Dishevelled	92..245	CDD:280528	44/169 (26%)
		PDZ_signaling	247..334	CDD:238492	69/86 (80%)
		DEP_dishevelled	413..496	CDD:239885	54/82 (66%)
		Dsh_C	500..706	CDD:289114	39/153 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344453
Domainoid	1	1.000	142	1.000	Domainoid score	I4567
eggNOG	1	0.900	-	-		E1_KOG3571
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20928
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1288
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D224059at33208
OrthoFinder	1	1.000	-	-		FOG0001069
OrthoInspector	1	1.000	-	-		otm44936
orthoMCL	1	0.900	-	-		OOG6_104083
Panther	1	1.100	-	-	LDO	PTHR10878
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X725
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760