Protein Alignment dsh and Dvl2

DIOPT Version :10

• Sequence 1: NP_511118.2
• Gene: dsh / 32078
• FlyBaseID: FBgn0000499
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001165527.1
• Gene: Dvl2 / 303251
• -ID: -
• Length: 736
• Species: Rattus norvegicus
• Alignment Length: 681
• Identity: 299/681 - (43%)
• Similarity: 392/681 - (57%)
• Gaps: 118/681 - (17%)

  Fly     3 ADRGGGQETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKE 67
            |..||..|||||||:|:|.||||||||:|:.::||.|||.||.:. ...||||||||.|||||||
  Rat     6 AGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRP-AGAKYFFKSMDQDFGVVKE 69

  Fly    68 EIADDSTILPCFNGRVVSWLVSADGTNQSDNCSELPTSECEL----------------GMGLTNR 116
            ||:|||..||||||||||||||:: :.|.:.......|..||                |:|
  Rat    70 EISDDSARLPCFNGRVVSWLVSSE-SPQPETAPPAHESRTELVPPPPPLPPLPPERTSGIG---- 129

  Fly   117 KLQQQQQQHQQQQQQQQQQHQQ-QQQQQQQQVQPVQLAQQQQQQVLHHQKMMGNP----LLQPPP 176
                 ..:...........|:. :.:.:.:.|..::..:.:::....|......|    .|:...
  Rat   130 -----DSRPPSFHPNVSSSHENLEPETETESVVSLRRDRPRRRDSSEHGAGGHRPGVPSRLERHL 189

  Fly   177 LTYQSASVL-SSDLDSTSLFGTESELTLDR--DMTDYSSVQRLQVRKKPQRRKKRAPSMSRTSSY 238
            ..|:|:|.| :|:|:||||..::.:.::.|  ..|:.||..|| :::..:|||:|.|.|.||||:
  Rat   190 AGYESSSTLMTSELESTSLGDSDEDDSMSRFSSSTEQSSASRL-LKRHRRRRKQRPPRMERTSSF 253

  Fly   239 SSITDSTMSLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMIL 303
            ||:||||||||||||::|||..||||||||||||..||||||:||||||||||.|||||||||:|
  Rat   254 SSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLL 318

  Fly   304 QVNDVNFENMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHT 368
            ||||:|||||:||:||||||::|.|||||.|.|||||||:|:.|||:||.||::||||.|||:|:
  Rat   319 QVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHS 383

  Fly   369 QALT----------SHDSIIADIAEP-------IKERLDQNNLEEIVKAMTKPDSGLEIRDRMWL 416
            .|||          |..:|.:..:.|       :...:|   :..:.|||..|:||||:||||||
  Rat   384 AALTGAFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHMD---MASVTKAMAAPESGLEVRDRMWL 445

  Fly   417 KITIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVVNEERN 481
            ||||||||:|:|.|:|:..:||...:|||||:..|.:|::..|:|||||:|||||||||..:
  Rat   446 KITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGD--- 507

  Fly   482 PNLLG--RGHLHPHQLPHGHGGHALSHADTESITSDIGPLPNP---PIYMPYSATYNPSHGYQP- 540
              |.|  ..:|....|....|....|..||      :.|||..   |:...:|..|...|.|.|
  Rat   508 --LSGGCESYLVNLSLNDNDGSSGASDQDT------LAPLPGATPWPLLPTFSYQYPAPHPYSPQ 564

  Fly   541 ---------IQYG---IAERHI----SSGSSSSD------------VLTSKDISASQSDITSVIH 577
                     ..||   .:.:|.    ||||:.||            ...||..|.|:|:::|
  Rat   565 PPPYHELSSYSYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESELSS--- 626

  Fly   578 QANQLTIAAHGSNKSSGSSNRGGGGGGGGGG 608
                          ..||..|||..||.|.|
  Rat   627 --------------RGGSLRRGGEPGGTGDG 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	59/82 (72%)
		Dishevelled	<174..248	CDD:460544	33/76 (43%)
		PDZ_Dishevelled-like	252..338	CDD:467201	68/85 (80%)
		DEP_dishevelled	395..478	CDD:239885	50/82 (61%)
Dvl2	NP_001165527.1	DAX	13..93	CDD:197474	59/80 (74%)
		Dishevelled	123..263	CDD:460544	40/149 (27%)
		PDZ_Dishevelled-like	267..353	CDD:467201	68/85 (80%)
		DEP_dishevelled	424..507	CDD:239885	50/82 (61%)
		Dsh_C	515..726	CDD:463531	39/152 (26%)