DRSC/TRiP Functional Genomics Resources

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Protein Alignment dsh and DVL3

DIOPT Version :9

Sequence 1:NP_511118.2 Gene:dsh / 32078 FlyBaseID:FBgn0000499 Length:623 Species:Drosophila melanogaster
Sequence 2:NP_004414.3 Gene:DVL3 / 1857 HGNCID:3087 Length:716 Species:Homo sapiens


Alignment Length:671 Identity:302/671 - (45%)
Similarity:391/671 - (58%) Gaps:135/671 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDST 74
            |||:|||:|.:.||||||:|:|:.:|||.|||.||  |..:||:||||||.|||||||||:||:.
Human     3 ETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVL--QRPSYKFFFKSMDDDFGVVKEEISDDNA 65

  Fly    75 ILPCFNGRVVSWLVSADGTNQ------SDNCSELPTSECELG--------------MGLTNRKLQ 119
            .|||||||||||||||:|::.      :||.||||......|              .|.:...|.
Human    66 KLPCFNGRVVSWLVSAEGSHPDPAPFCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLD 130

  Fly   120 QQQQQHQQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLHHQKMMGNPLLQPPPLTYQSASV 184
            ...:.......|:::..::...:...::......:::::                 |..|.|:|.
Human   131 NDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRRE-----------------PGGYDSSST 178

  Fly   185 L-SSDLDSTSLFGTESELTLDR--DMTDYSSVQRLQVRKKPQRRKKRAPSMSRTSSYSSITDSTM 246
            | ||:|::||.|.::.:.:..|  ..|:.||..||..|.|.:|||::...:.|:||:||||||||
Human   179 LMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTM 243

  Fly   247 SLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMILQVNDVNFE 311
            |||||||::|||..||||||||||||..||||||:||||||||||.|||||||||:||||::|||
Human   244 SLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFE 308

  Fly   312 NMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHTQALT---- 372
            ||:||:|||||||:|.|||||.|.|||||||:|:|.||:||:||:|||||.|||:||.|:|    
Human   309 NMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFP 373

  Fly   373 -------------SHDSIIADIAEPIKERLD------QNNLEEIVKAMTKPDSGLEIRDRMWLKI 418
                         :..||.:.|  |..||||      .:::..|||||..|:||||:||||||||
Human   374 AYGMSPSLSTITSTSSSITSSI--PDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKI 436

  Fly   419 TIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVVNE--ERN 481
            ||||||||:|.|:|:..|||...||||||:..|.:|::.:|:|||||:||||||||:..:  ...
Human   437 TIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNM 501

  Fly   482 PNLLGRGHLHPHQLPHGHGGHALSHADTESITSDIGPLPNP-----PIYMPYS-----ATYNPSH 536
            .||    .||.|.     |....|..||      :.|||:|     |:..||.     ..|||..
Human   502 ANL----SLHDHD-----GSSGASDQDT------LAPLPHPGAAPWPMAFPYQYPPPPHPYNPHP 551

  Fly   537 GYQPIQY----GIAERHISSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAHGSNKSSGSSN 597
            |:..:.|    |.|....|.||.||                              |||: |||..
Human   552 GFPELGYSYGGGSASSQHSEGSRSS------------------------------GSNR-SGSDR 585

  Fly   598 R------GGGGGGGGGGNNTN 612
            |      .|....||.|:.::
Human   586 RKEKDPKAGDSKSGGSGSESD 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dshNP_511118.2 DAX 8..91 CDD:197474 57/80 (71%)
Dishevelled <166..248 CDD:280528 33/84 (39%)
PDZ_signaling 250..337 CDD:238492 69/86 (80%)
DEP_dishevelled 395..478 CDD:239885 54/82 (66%)
DVL3NP_004414.3 DAX 1..82 CDD:197474 57/80 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 85..235 34/166 (20%)
Dishevelled 92..245 CDD:396795 43/169 (25%)
PDZ_signaling 247..334 CDD:238492 69/86 (80%)
DEP_dishevelled 413..496 CDD:239885 54/82 (66%)
Dsh_C 500..706 CDD:403510 39/153 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 546..691 23/92 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165150916
Domainoid 1 1.000 142 1.000 Domainoid score I4685
eggNOG 1 0.900 - - E1_KOG3571
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20928
Inparanoid 1 1.050 502 1.000 Inparanoid score I1361
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D224059at33208
OrthoFinder 1 1.000 - - FOG0001069
OrthoInspector 1 1.000 - - otm40798
orthoMCL 1 0.900 - - OOG6_104083
Panther 1 1.100 - - LDO PTHR10878
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4545
SonicParanoid 1 1.000 - - X725
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.790

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