DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsh and DVL1

DIOPT Version :9

Sequence 1:	NP_511118.2	Gene:	dsh / 32078	FlyBaseID:	FBgn0000499	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001317240.1	Gene:	DVL1 / 1855	HGNCID:	3084	Length:	695	Species:	Homo sapiens

Alignment Length:	675	Identity:	278/675 - (41%)
Similarity:	380/675 - (56%)	Gaps:	144/675 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVL-NKQNNNYKYFFKSMDADFGVVKEEIADDS 73
            |||:|||:|:|.||||||:|:...:|||.|||.|| |:..:.||:||||||.|||||||||.||:
Human     3 ETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDN 67

  Fly    74 TILPCFNGRVVSWLVSADGTNQ------SDNCSELPTSECELG------------------MGLT 114
            ..|||||||||||||.|:|.:.      :|:.::||......|                  .|:.
Human    68 AKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMD 132

  Fly   115 NRKLQQQQQQHQQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLHHQKMMGNP-------LL 172
            |....:....|::::.:::.:.:..:..                         |:|       :.
Human   133 NETGTESMVSHRRERARRRNREEAARTN-------------------------GHPRGDRRRDVG 172

  Fly   173 QPPPLTYQSASVLSSDLDSTSLFGTESELTLDR--DMTDYSSVQRLQVRKKPQRRKKRAPSMSRT 235
            .||.   .:::.|||:|:|:|...::.:.:..|  ..|:.|:..||..:.|.:|||:|.....|.
Human   173 LPPD---SASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRA 234

  Fly   236 SSYSSITDSTMSLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGD 300
            ||:||||||||||||:||::|||..:|||||||||||..||||||:||||||||||.||||||||
Human   235 SSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGD 299

  Fly   301 MILQVNDVNFENMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWV 365
            |:|||||||||||:||:|||||||:|.:.|||.|.|||||||.|:.|||:||.:|||||||.||:
Human   300 MLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWL 364

  Fly   366 AHTQAL------------------TSHDSIIADIAEPIKERLDQ------NNLEEIVKAMTKPDS 406
            :||.||                  ||..|:.:.:  |...:|::      :::..:|:.|..|||
Human   365 SHTAALTGALPRYGTSPCSSAVTRTSSSSLTSSV--PGAPQLEEAPLTVKSDMSAVVRVMQLPDS 427

  Fly   407 GLEIRDRMWLKITIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQ 471
            ||||||||||||||.||.||||.|:|:..:||..::|||||:..|::|:..:::|||||:|||||
Human   428 GLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQ 492

  Fly   472 CYYVVNEERNPNLLGRGHLHPHQLPHGHGGHALSHADTESITSDIGPLPNPPIYMPYSATYNPSH 536
            ||||..:..: ||.        .|....|....|..||      :.|||:|      :|.:....
Human   493 CYYVFGDLCS-NLA--------TLNLNSGSSGTSDQDT------LAPLPHP------AAPWPLGQ 536

  Fly   537 GYQPIQY--------------GIAERHISSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAH 587
            || |.||              |.:....|:||..|:  .||...:::|
Human   537 GY-PYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSE--GSKSSGSTRS----------------- 581

  Fly   588 GSNKSSGSSNRGGGGGGGGGGNNTN 612
             |.::.|........|.||.|:.::
Human   582 -SRRAPGREKERRAAGAGGSGSESD 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	56/81 (69%)
		Dishevelled	<166..248	CDD:280528	31/90 (34%)
		PDZ_signaling	250..337	CDD:238492	67/86 (78%)
		DEP_dishevelled	395..478	CDD:239885	50/82 (61%)
DVL1	NP_001317240.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..237		29/175 (17%)
DVL1	NP_001317240.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..667		14/83 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150917
Domainoid	1	1.000	142	1.000	Domainoid score	I4685
eggNOG	1	0.900	-	-		E1_KOG3571
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1361
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D224059at33208
OrthoFinder	1	1.000	-	-		FOG0001069
OrthoInspector	1	1.000	-	-		otm40798
orthoMCL	1	0.900	-	-		OOG6_104083
Panther	1	1.100	-	-	O	PTHR10878
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X725
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760