Protein Alignment dsh and dvl3b

DIOPT Version :10

• Sequence 1: NP_511118.2
• Gene: dsh / 32078
• FlyBaseID: FBgn0000499
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_001920242.3
• Gene: dvl3b / 100149082
• ZFINID: ZDB-GENE-121101-2
• Length: 706
• Species: Danio rerio
• Alignment Length: 691
• Identity: 302/691 - (43%)
• Similarity: 398/691 - (57%)
• Gaps: 158/691 - (22%)

  Fly    10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDST 74
            |||:|||:|::.||||:|:|||:..|||.|||.||||.  |||:||||||.|||||||||:||:.
Zfish     3 ETKIIYHLDEQETPYLIKLPIPAENVTLADFKNVLNKP--NYKFFFKSMDDDFGVVKEEISDDNA 65

  Fly    75 ILPCFNGRVVSWLVSADGTNQSDN---CSELPT--------------------------SECELG 110
            .|||||||||||||||||::.||.   |::...                          |:.:||
Zfish    66 KLPCFNGRVVSWLVSADGSHGSDGGSVCADTQADLQPPLERTGGIGDSRPPSFHANAAGSQDDLG 130

  Fly   111 ------MGLTNRKLQQQQQQHQQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLHHQKMMGN 169
                  :|.:.|:.:::::...:::.:::..|.                        |..::.|:
Zfish   131 NDTEPEVGPSLRRERERERDRDRERPRRKDTHD------------------------HGGRLNGH 171

  Fly   170 PLLQ--PPPLTYQSASVL-SSDLDSTSLFGTESELTLDR--DMTDYSSVQRLQVRKKPQRRKKRA 229
            ...:  |....|:|:|.| ||:||:||.|.:|.:.:..|  ..|:.|:..||..|.:.:|||.:|
Zfish   172 SRAERRPDIAGYESSSTLMSSELDTTSFFDSEDDDSASRFSSSTEQSTSSRLMRRHRRRRRKPKA 236

  Fly   230 PSMSRTSSYSSITDSTMSLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDG 294
            |.|.|:||:|||||||||||||||::|||..||||||||||||..||||||:||||||||||.||
Zfish   237 PRMERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADG 301

  Fly   295 RIEPGDMILQVNDVNFENMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPI 359
            |||||||:|||||:|||||:||:|||||||:|.|||||.|.|||||||||:..||:||:||:|||
Zfish   302 RIEPGDMLLQVNDINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPNPRSCFTLPRSEPIRPI 366

  Fly   360 DPGAWVAHTQALT-----------------SHDSIIADIAEPIKERLD------QNNLEEIVKAM 401
            ||.|||:||.|:|                 :..||.:.|  |..||.:      .:::..:.|||
Zfish   367 DPAAWVSHTAAMTGAYPVYGMSPSMSTITSTSSSITSSI--PETERFEDFHLSIHSDMAAVAKAM 429

  Fly   402 TKPDSGLEIRDRMWLKITIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKL 466
            ..|:||||:||||||||||||||||:|.|:|:...||...||||||:..|.:|::.||:|||||:
Zfish   430 ASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHRVEGFTDRREARKYASNLLKAGYIRHTVNKI 494

  Fly   467 TFSEQCYYVVNEERNPNLLGRGHLHPHQLPHGHGGHALSHADTESITSDIGPLPNP-----PIYM 526
            ||||||||:..:... |:... .||.|.     |....|..||      :.|||:|     |:..
Zfish   495 TFSEQCYYIFGDVCG-NMASL-TLHDHD-----GSSGASDQDT------LAPLPHPGVAPWPLAF 546

  Fly   527 PYS----ATYNPSHGYQPIQYGIAERHISSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAH 587
            ||.    ..|||...::| .|.......|.||..|:
Zfish   547 PYQYPIPHPYNPHPVHEP-GYSFTAGGGSVGSPHSE----------------------------- 581

  Fly   588 GSNKSSGSSNRGG-------------GGGGGGGGNNTNDQD 615
             .::||| |||.|             .||..|.|:.::.::
Zfish   582 -GSRSSG-SNRSGTKNDTNAAPAAPESGGRSGSGSESDRRE 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	59/80 (74%)
		Dishevelled	<174..248	CDD:460544	36/76 (47%)
		PDZ_Dishevelled-like	252..338	CDD:467201	69/85 (81%)
		DEP_dishevelled	395..478	CDD:239885	52/82 (63%)
dvl3b	XP_001920242.3	DAX	1..82	CDD:197474	59/80 (74%)
		Dishevelled	88..255	CDD:460544	46/190 (24%)
		PDZ_Dishevelled-like	259..345	CDD:467201	69/85 (81%)
		DEP_dishevelled	423..506	CDD:239885	52/82 (63%)
		Dsh_C	510..696	CDD:463531	35/155 (23%)