DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsh and dvl3

DIOPT Version :9

Sequence 1:	NP_511118.2	Gene:	dsh / 32078	FlyBaseID:	FBgn0000499	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001116929.1	Gene:	dvl3 / 100144702	XenbaseID:	XB-GENE-977362	Length:	713	Species:	Xenopus tropicalis

Alignment Length:	664	Identity:	307/664 - (46%)
Similarity:	396/664 - (59%)	Gaps:	123/664 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDST 74
            |||||||:|::.||||||:|:|:.:|||.|||.||||.  |||:||||||.|||||||||:||:.
Frog     3 ETKVIYHLDEQETPYLVKLPVPAEKVTLGDFKNVLNKP--NYKFFFKSMDDDFGVVKEEISDDNA 65

  Fly    75 ILPCFNGRVVSWLVSADGTNQ------SDNCSELPTS-ECELGMGLT-------NRKLQQQQQQH 125
            .|||||||||.|||||||:..      :||.|:||.. |...|:|.:       |.:..|:...:
Frog    66 KLPCFNGRVVCWLVSADGSQSDAGSVCADNQSDLPPPIERTGGIGDSRPPSFHPNTRGSQENLDN 130

  Fly   126 QQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLHHQKMMGNPLLQPPPLTYQSASVL-SSDL 189
            :.:.......|:::.::::   .|....:......:..::..|.         |:|:|.| ||:|
Frog   131 ETETDSVVSAHRERPRRKE---TPEHATRLNGTSKMERRRDTGG---------YESSSTLMSSEL 183

  Fly   190 DSTSLFGTESELTLDR--DMTDYSSVQRLQVRKKPQRRKKRAPSMSRTSSYSSITDSTMSLNIIT 252
            ||||.|.::.:.:..|  :.|:.||..||..|.|.:|||.:||.:.|:||:||||||||||||||
Frog   184 DSTSFFDSDEDDSTSRFSNSTEQSSASRLMRRHKRRRRKPKAPRIERSSSFSSITDSTMSLNIIT 248

  Fly   253 VSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMILQVNDVNFENMTNDE 317
            |::|||..||||||||||||..||||||:||||||||||.|||||||||:|||||.|||||:||:
Frog   249 VTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDTNFENMSNDD 313

  Fly   318 AVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHTQALT---------- 372
            |||||||:|.|||||.|.|||||||:|:..||:||:||:|||||.|||:||.|:|
Frog   314 AVRVLREIVHKPGPITLTVAKCWDPSPRNCFTLPRSEPIRPIDPAAWVSHTAAMTGSYPAYGMSP 378

  Fly   373 -------SHDSIIADIAEPIKERLD------QNNLEEIVKAMTKPDSGLEIRDRMWLKITIPNAF 424
                   :..||.:.|  |..||.|      .:::..|||||..|:||||:||||||||||||||
Frog   379 SMSTITSTSSSITSSI--PETERFDDFQLSIHSDMVTIVKAMRSPESGLEVRDRMWLKITIPNAF 441

  Fly   425 IGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVVNEERNPNLLGRGH 489
            ||:|.|:|:..:||...||||||:..|.:|::.||:|||||:||||||||:..:     |.|
Frog   442 IGSDVVDWLYHHVEGFTDRREARKYASNLLKAGYIRHTVNKITFSEQCYYIFGD-----LCG--- 498

  Fly   490 LHPHQLPHGHGGHALSHADTESITSD---IGPLPNP-----PIYMPYS----ATYNPSHGYQPIQ 542
                    .....:|:..|..|.|||   :.|||:|     ||...|.    ..|:|..|:....
Frog   499 --------NMANLSLNDHDGSSGTSDQDTLAPLPHPGAAPWPIAFQYQYPLPHPYSPHPGFPDPA 555

  Fly   543 Y----GIAERHISSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAHGSNKSSGSSN-----R 598
            |    |.|....|.||.||                              |||:||....     :
Frog   556 YSYGGGSAGSQHSEGSRSS------------------------------GSNRSSTEKRKEREAK 590

  Fly   599 GGGGGGGGGGNNTN 612
            ||....||.|:.::
Frog   591 GGDTKSGGSGSESD 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	59/80 (74%)
		Dishevelled	<166..248	CDD:280528	37/84 (44%)
		PDZ_signaling	250..337	CDD:238492	70/86 (81%)
		DEP_dishevelled	395..478	CDD:239885	54/82 (66%)
dvl3	NP_001116929.1	DAX	1..82	CDD:197474	59/80 (74%)
		Dishevelled	87..244	CDD:367060	49/168 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..235		41/159 (26%)
		PDZ_signaling	246..333	CDD:238492	70/86 (81%)
		DEP_dishevelled	413..495	CDD:239885	54/81 (67%)
		Dsh_C	499..701	CDD:372040	34/136 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..527		8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..652		21/90 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20928
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1290
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D224059at33208
OrthoFinder	1	1.000	-	-		FOG0001069
OrthoInspector	1	1.000	-	-		otm47989
Panther	1	1.100	-	-	LDO	PTHR10878
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4545
SonicParanoid	1	1.000	-	-		X725
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100