Protein Alignment dsh and dvl1

DIOPT Version :10

• Sequence 1: NP_511118.2
• Gene: dsh / 32078
• FlyBaseID: FBgn0000499
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_012821471.1
• Gene: dvl1 / 100144639
• XenbaseID: XB-GENE-483870
• Length: 707
• Species: Xenopus tropicalis
• Alignment Length: 680
• Identity: 300/680 - (44%)
• Similarity: 391/680 - (57%)
• Gaps: 133/680 - (19%)

  Fly    10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVL-NKQNNNYKYFFKSMDADFGVVKEEIADDS 73
            ||::|||||:|.||||||:|:|..:|||.|||.|| |:..::||:||||||.|||||||||:||:
 Frog     3 ETRIIYHIDEEETPYLVKLPVPPEKVTLADFKNVLSNRPVHHYKFFFKSMDQDFGVVKEEISDDN 67

  Fly    74 TILPCFNGRVVSWLVSADGTNQSDNCSELPTSECELGM-------------------------GL 113
            ..|||||||||||||.|: ::.||..|:...|..:|.:                         ||
 Frog    68 AKLPCFNGRVVSWLVLAE-SSHSDGGSQSTESRTDLPLPIERTGGIGDSRPPSFHPNASSSRDGL 131

  Fly   114 TNRKLQQQQQQHQQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLHHQKMMGNPLLQ--PPP 176
            .|.........|      ::.:|:::.::....|                .::.|:|.|.  ..|
 Frog   132 DNETGTDSVVSH------RRDRHRRKNRETHDDV----------------PRINGHPKLDRIRDP 174

  Fly   177 LTYQSAS-VLSSDLDSTSLFGTESELTLDR--DMTDYSSVQRLQVRKKPQRRKKRAPSMSRTSSY 238
            ..|.||| |:||:|:|:|...::.:....|  ..|:.|:..||..:.|.:|||::...:.|:||:
 Frog   175 GGYDSASTVMSSELESSSFVDSDEDENTSRLSSSTEQSTSSRLIRKHKRRRRKQKMRQIDRSSSF 239

  Fly   239 SSITDSTMSLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMIL 303
            |||||||||||||||::|||..||||||||||||..||||||:||||||||||.|||||||||:|
 Frog   240 SSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLL 304

  Fly   304 QVNDVNFENMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHT 368
            ||||||||||:||:|||||||:|.|||||.|.|||||||.|:.||||||.||||||||.||:.||
 Frog   305 QVNDVNFENMSNDDAVRVLREIVSKPGPISLTVAKCWDPTPRSYFTIPRAEPVRPIDPAAWITHT 369

  Fly   369 QALTS---------HDSIIA------DIAEPIKERLD------QNNLEEIVKAMTKPDSGLEIRD 412
            .|||.         ..|||.      ..::|..|:.:      ::::..|||.|..|||||||||
 Frog   370 SALTGAYPRYGMSPSMSIITCTSSSLTSSKPESEKQEDSPLSVKSDMATIVKVMQLPDSGLEIRD 434

  Fly   413 RMWLKITIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVVN 477
            ||||||||.||.||||.|:|:..:||..::|||||:..|:||:..|::|||||:|||||||||..
 Frog   435 RMWLKITISNAVIGADVVDWLYTHVEGFKERREARKYASSMLKHGYLRHTVNKITFSEQCYYVFG 499

  Fly   478 EERNPNLLGRGHLHPHQLPHGHGGHALSHADTESITSD---IGPLPNP----PIYMPYSATY--- 532
            :.       .|::....|..|..|           |||   :.|||:|    |:...||..|
 Frog   500 DL-------CGNVAALNLNEGSSG-----------TSDQDTLAPLPHPAAPWPLGQGYSYQYPLA 546

  Fly   533 ----NPSHGYQPIQYGIAERHISSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAHGSNKSS 593
                .|::......||..    |:||..|:  .||...:|:|:              ..|...|.
 Frog   547 PPCFPPTYQEPGFSYGSG----SAGSQHSE--GSKSSGSSRSN--------------REGKRSSG 591

  Fly   594 GSSNRGGGGGGGG------GGNNTNDQDVS 617
            ...:|...|.|.|      .|.:.|::.:|
 Frog   592 REKDRRSTGSGSGSDRAPRSGGSKNERPLS 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	57/81 (70%)
		Dishevelled	<174..248	CDD:460544	31/76 (41%)
		PDZ_Dishevelled-like	252..338	CDD:467201	70/85 (82%)
		DEP_dishevelled	395..478	CDD:239885	54/82 (66%)
dvl1	XP_012821471.1	DAX	1..85	CDD:197474	57/81 (70%)
		Dishevelled	90..249	CDD:460544	44/180 (24%)
		PDZ_Dishevelled-like	253..339	CDD:467201	70/85 (82%)
		DEP_dishevelled	417..500	CDD:239885	54/82 (66%)
		Dsh_C	504..697	CDD:463531	34/149 (23%)