DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsh and dvl1

DIOPT Version :9

Sequence 1:	NP_511118.2	Gene:	dsh / 32078	FlyBaseID:	FBgn0000499	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_012821471.1	Gene:	dvl1 / 100144639	XenbaseID:	XB-GENE-483870	Length:	707	Species:	Xenopus tropicalis

Alignment Length:	680	Identity:	300/680 - (44%)
Similarity:	391/680 - (57%)	Gaps:	133/680 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVL-NKQNNNYKYFFKSMDADFGVVKEEIADDS 73
            ||::|||||:|.||||||:|:|..:|||.|||.|| |:..::||:||||||.|||||||||:||:
Frog     3 ETRIIYHIDEEETPYLVKLPVPPEKVTLADFKNVLSNRPVHHYKFFFKSMDQDFGVVKEEISDDN 67

  Fly    74 TILPCFNGRVVSWLVSADGTNQSDNCSELPTSECELGM-------------------------GL 113
            ..|||||||||||||.|: ::.||..|:...|..:|.:                         ||
Frog    68 AKLPCFNGRVVSWLVLAE-SSHSDGGSQSTESRTDLPLPIERTGGIGDSRPPSFHPNASSSRDGL 131

  Fly   114 TNRKLQQQQQQHQQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLHHQKMMGNPLLQ--PPP 176
            .|.........|      ::.:|:::.::....|                .::.|:|.|.  ..|
Frog   132 DNETGTDSVVSH------RRDRHRRKNRETHDDV----------------PRINGHPKLDRIRDP 174

  Fly   177 LTYQSAS-VLSSDLDSTSLFGTESELTLDR--DMTDYSSVQRLQVRKKPQRRKKRAPSMSRTSSY 238
            ..|.||| |:||:|:|:|...::.:....|  ..|:.|:..||..:.|.:|||::...:.|:||:
Frog   175 GGYDSASTVMSSELESSSFVDSDEDENTSRLSSSTEQSTSSRLIRKHKRRRRKQKMRQIDRSSSF 239

  Fly   239 SSITDSTMSLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMIL 303
            |||||||||||||||::|||..||||||||||||..||||||:||||||||||.|||||||||:|
Frog   240 SSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLL 304

  Fly   304 QVNDVNFENMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHT 368
            ||||||||||:||:|||||||:|.|||||.|.|||||||.|:.||||||.||||||||.||:.||
Frog   305 QVNDVNFENMSNDDAVRVLREIVSKPGPISLTVAKCWDPTPRSYFTIPRAEPVRPIDPAAWITHT 369

  Fly   369 QALTS---------HDSIIA------DIAEPIKERLD------QNNLEEIVKAMTKPDSGLEIRD 412
            .|||.         ..|||.      ..::|..|:.:      ::::..|||.|..|||||||||
Frog   370 SALTGAYPRYGMSPSMSIITCTSSSLTSSKPESEKQEDSPLSVKSDMATIVKVMQLPDSGLEIRD 434

  Fly   413 RMWLKITIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVVN 477
            ||||||||.||.||||.|:|:..:||..::|||||:..|:||:..|::|||||:|||||||||..
Frog   435 RMWLKITISNAVIGADVVDWLYTHVEGFKERREARKYASSMLKHGYLRHTVNKITFSEQCYYVFG 499

  Fly   478 EERNPNLLGRGHLHPHQLPHGHGGHALSHADTESITSD---IGPLPNP----PIYMPYSATY--- 532
            :.       .|::....|..|..|           |||   :.|||:|    |:...||..|
Frog   500 DL-------CGNVAALNLNEGSSG-----------TSDQDTLAPLPHPAAPWPLGQGYSYQYPLA 546

  Fly   533 ----NPSHGYQPIQYGIAERHISSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAHGSNKSS 593
                .|::......||..    |:||..|:  .||...:|:|:              ..|...|.
Frog   547 PPCFPPTYQEPGFSYGSG----SAGSQHSE--GSKSSGSSRSN--------------REGKRSSG 591

  Fly   594 GSSNRGGGGGGGG------GGNNTNDQDVS 617
            ...:|...|.|.|      .|.:.|::.:|
Frog   592 REKDRRSTGSGSGSDRAPRSGGSKNERPLS 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	57/81 (70%)
		Dishevelled	<166..248	CDD:280528	34/86 (40%)
		PDZ_signaling	250..337	CDD:238492	71/86 (83%)
		DEP_dishevelled	395..478	CDD:239885	54/82 (66%)
dvl1	XP_012821471.1	DAX	1..85	CDD:197474	57/81 (70%)
		Dishevelled	90..249	CDD:367060	44/180 (24%)
		PDZ_signaling	251..338	CDD:238492	71/86 (83%)
		DEP_dishevelled	417..500	CDD:239885	54/82 (66%)
		Dsh_C	504..697	CDD:372040	34/149 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1290
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D224059at33208
OrthoFinder	1	1.000	-	-		FOG0001069
OrthoInspector	1	1.000	-	-		otm47989
Panther	1	1.100	-	-	O	PTHR10878
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X725
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070