DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS1 and MOGS

DIOPT Version :9

Sequence 1:	NP_001245621.1	Gene:	GCS1 / 32073	FlyBaseID:	FBgn0030289	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_006293.2	Gene:	MOGS / 7841	HGNCID:	24862	Length:	837	Species:	Homo sapiens

Alignment Length:	788	Identity:	345/788 - (43%)
Similarity:	453/788 - (57%)	Gaps:	81/788 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 PDRYWGSYRPLTYFGMKTRDPHSLVMGLMWYTPSNLGPGGQGIRHWCEQGDKLDSYGWTHHDGRS 165
            ||.:||:|||..|||||||.|..|:.|||| ......||...:||.|||||.:..|||..|||.|
Human    92 PDLFWGTYRPHVYFGMKTRSPKPLLTGLMW-AQQGTTPGTPKLRHTCEQGDGVGPYGWEFHDGLS 155

  Fly   166 FGVQEIQDLPFELKTSFVKYPEGKQYGGDWTARISVR---NTTRAWDKSISLIWYVALDER---- 223
            ||.|.|||....|.|.|||.| |.|:||||:.|::|.   :.|.|. ..:||.:||..|.:
Human   156 FGRQHIQDGALRLTTEFVKRP-GGQHGGDWSWRVTVEPQDSGTSAL-PLVSLFFYVVTDGKEVLL 218

  Fly   224 ----TNGHIKYVSDDKSPEPGVYGEAQGLGEFQVRFHAV----KGKILHK--SY--LSTVAPSLA 276
                ..|.:|::|          |....||:|  ||..:    .|....|  ||  ..|..|.|.
Human   219 PEVGAKGQLKFIS----------GHTSELGDF--RFTLLPPTSPGDTAPKYGSYNVFWTSNPGLP 271

  Fly   277 KLKDTLFSHFRAFADKR-----GNRFIGLPGEIVSQNGLPSSNPEPNFIAIQITAEVDFTLDITY 336
            .|.:.:.|...::...|     ..|::||||.:..::..||...:..|:..|:|.::..:::..:
Human   272 LLTEMVKSRLNSWFQHRPPGAPPERYLGLPGSLKWEDRGPSGQGQGQFLIQQVTLKIPISIEFVF 336

  Fly   337 QSTSGFSLG-ESIPKPPTGRAYQDSLQAKIAQFEQRFEDRFQLKQKGHSPEEVRFARNALSNLLG 400
            :|.|..:.| :::|: ..|.....:|::....|.:|||..||||:||.|..|....:.|||.|||
Human   337 ESGSAQAGGNQALPR-LAGSLLTQALESHAEGFRERFEKTFQLKEKGLSSGEQVLGQAALSGLLG 400

  Fly   401 GIGYFYGSSRV----------QSVYTKNPVPYWKAPLYTAVPSRSFFPRGFLWDEGFHGLLISAW 455
            |||||||...|          |.|   :|..:...||:||||||||||||||||||||.|::..|
Human   401 GIGYFYGQGLVLPDIGVEGSEQKV---DPALFPPVPLFTAVPSRSFFPRGFLWDEGFHQLVVQRW 462

  Fly   456 DIDIELDIICHWFDLLNVEGWIPREQILGVEALAKVPEEFVTQRNSNANPPTFFLTLKKLLTSHR 520
            |..:..:.:.||..|||.:|||.||||||.||.|:||.||:.||..:|||||..|.:     :|.
Human   463 DPSLTREALGHWLGLLNADGWIGREQILGDEARARVPPEFLVQRAVHANPPTLLLPV-----AHM 522

  Fly   521 AELSQNGRLATLERLYPRVQAWFNWFNTTQRGEVLGTYLWRGRNATTTRELNPKSLSSGLDDYPR 585
            .|:.....||.|.:..||:.|||:|.:.:|.|.:..:|.||||:......||||:|.||||||||
Human   523 LEVGDPDDLAFLRKALPRLHAWFSWLHQSQAGPLPLSYRWRGRDPALPTLLNPKTLPSGLDDYPR 587

  Fly   586 ASHPTDKERHLDLRCWIALAAGVMAELSTLLGKDD--AKYYETASYLTDNVRLNRLHLAPYSEQY 648
            ||||:..|||||||||:||.|.|:..|:..||:.:  |:....|:.|.....|:.||.||....:
Human   588 ASHPSVTERHLDLRCWVALGARVLTRLAEHLGEAEVAAELGPLAASLEAAESLDELHWAPELGVF 652

  Fly   649 ADWGLHTDQVKLK-RPPSMAPQQQQRHHHQHYQLPEMQRVTGE-LPTYQFVDSAFGYVSLFPLLL 711
            ||:|.||..|:|| |||.                 .:.||.|. .|..|:|| |.||||||||||
Human   653 ADFGNHTKAVQLKPRPPQ-----------------GLVRVVGRPQPQLQYVD-ALGYVSLFPLLL 699

  Fly   712 EQLDHDSPYLTKLLNDLRDPEQLWTNYGLRSLSKRSPLYMQRNTEHDPPYWRGPIWININYLAAK 776
            ..||..|..|..||:.|.|...||:.:|||||:..|..|.|||:|||||||||.:|:|:||||..
Human   700 RLLDPTSSRLGPLLDILADSRHLWSPFGLRSLAASSSFYGQRNSEHDPPYWRGAVWLNVNYLALG 764

  Fly   777 ALHHYGKIDGPNAALARQIYAELRDNLVGNILRQYKRSGYLWEQYDDTSGEGKGCNPFTGWTATV 841
            ||||||.::||:.|.|.:::.|||.|:|||:.|||:.:|:|||||.|..|.|.||.||.|||:.|
Human   765 ALHHYGHLEGPHQARAAKLHGELRANVVGNVWRQYQATGFLWEQYSDRDGRGMGCRPFHGWTSLV 829

  Fly   842 VLLMAEQF 849
            :|.|||.:
Human   830 LLAMAEDY 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS1	NP_001245621.1	Glyco_hydro_63N	104..283	CDD:293528	78/197 (40%)
GCS1	NP_001245621.1	Glyco_hydro_63	352..847	CDD:281228	247/508 (49%)
MOGS	NP_006293.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		Endoplasmic reticulum targeting	3..9
		Required for endoplasmic reticulum targeting. /evidence=ECO:0000250	76..137		24/45 (53%)
		Glyco_hydro_63N	94..>244	CDD:319009	70/164 (43%)
		Glyco_hydro_63	352..835	CDD:308692	247/508 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158398
Domainoid	1	1.000	462	1.000	Domainoid score	I483
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4593
Inparanoid	1	1.050	591	1.000	Inparanoid score	I989
Isobase	1	0.950	-	0	Normalized mean entropy	S1986
OMA	1	1.010	-	-		QHG53903
OrthoDB	1	1.010	-	-		D162821at33208
OrthoFinder	1	1.000	-	-		FOG0004064
OrthoInspector	1	1.000	-	-		oto89586
orthoMCL	1	0.900	-	-		OOG6_103455
Panther	1	1.100	-	-	LDO	PTHR10412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R480
SonicParanoid	1	1.000	-	-		X2818
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890