DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS1 and Mogs

DIOPT Version :9

Sequence 1:	NP_001245621.1	Gene:	GCS1 / 32073	FlyBaseID:	FBgn0030289	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_065644.2	Gene:	Mogs / 57377	MGIID:	1929872	Length:	834	Species:	Mus musculus

Alignment Length:	887	Identity:	365/887 - (41%)
Similarity:	480/887 - (54%)	Gaps:	113/887 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ARNTGSSSGSTPAASSSGSSAAAAAAAAAAAAAASNAKQKQRSPRFSLSSNLILDKWKTMIGCVC 66
            ||..|...|....|..|.|.||.|....|.|              |.||...:| .|..:...:.
Mouse    22 ARAAGRRDGRAGGARGSASGAALAVVVLALA--------------FGLSGRWVL-AWLRVRRALT 71

  Fly    67 LAIASYFGYLGYLETRVNTPFDHQKMVVHAGLEQPDRYWGSYRPLTYFGMKTRDPHSLVMGLMWY 131
            |..|.           ...|.|.....|     .|:.:||:|||..|||||||.|..|:.||||.
Mouse    72 LHPAP-----------SALPPDSSSPAV-----APELFWGTYRPHVYFGMKTRSPKPLLTGLMWA 120

  Fly   132 -------TPSNLGPGGQGIRHWCEQGDKLDSYGWTHHDGRSFGVQEIQDLPFELKTSFVKYPEGK 189
                   ||..|       ||.|||||.:..|||..||||:||.|.|.|....|.|.|||.| |.
Mouse   121 QQGATPGTPPKL-------RHTCEQGDGVGPYGWEFHDGRTFGRQHIHDGALRLTTEFVKRP-GG 177

  Fly   190 QYGGDWTARISVRNTTRAWDK--SISLIWYVALDER--------TNGHIKYVSDDKSPEPGVYGE 244
            |:||||:.|::|.........  .:||.:||..|.:        ..|.:|.:|          |.
Mouse   178 QHGGDWSWRVTVEPQASGTPSFPLVSLFFYVVTDGQEVLLPEIGAKGQLKSIS----------GH 232

  Fly   245 AQGLGEFQVRF--HAVKGKIL--HKSY--LSTVAPSLAKLKDTLFSHFRAFADKR-----GNRFI 298
            ...||:|::..  ....|..:  |.||  ..:..|.|.:|.|.:.|...::...|     .:|::
Mouse   233 TSELGDFRLTLLPPTSPGDTVPKHGSYNVFWSSNPGLPQLTDMVKSRLNSWFQHRPPGASPDRYL 297

  Fly   299 GLPGEIVSQNGLPSSNPEPNFIAIQITAEVDFTLDITYQSTSGFSLGESIPKPPTGRAYQDSLQA 363
            ||||.:..:...||.  :..|:..|:|.:..|:::..::|.|..:.|........|.....:|::
Mouse   298 GLPGSLKWEERGPSG--QGQFLIQQVTLKAPFSVEFVFESGSAATGGNQASGRLVGSQLTQALES 360

  Fly   364 KIAQFEQRFEDRFQLKQKGHSPEEVRFARNALSNLLGGIGYFYG-------SSRVQSVYTKNPVP 421
            ..|.|::|||..||||:||.||||....:.|||.||||||||||       :|...|....:|..
Mouse   361 HAAAFKERFEKTFQLKEKGLSPEEQALGQVALSGLLGGIGYFYGQGLVLPDTSMEGSEQKMDPAL 425

  Fly   422 YWKAPLYTAVPSRSFFPRGFLWDEGFHGLLISAWDIDIELDIICHWFDLLNVEGWIPREQILGVE 486
            :...||::.||||||||||||||||||.|::..||..:..:.:.||..|||.:|||.||||||.|
Mouse   426 FPPVPLFSGVPSRSFFPRGFLWDEGFHQLVVQRWDPHLTREALGHWLGLLNADGWIGREQILGDE 490

  Fly   487 ALAKVPEEFVTQRNSNANPPTFFLTLKKLLTSHRAELSQNGRLATLERLYPRVQAWFNWFNTTQR 551
            |.|:||.||:.||.::|||||..|.:..:|..|..:     .||.|.:.:||:.|||:|.:.:|.
Mouse   491 ARARVPPEFLVQRAAHANPPTLLLPVVHMLEGHDPD-----DLAFLRKAFPRLHAWFSWLHQSQA 550

  Fly   552 GEVLGTYLWRGRNATTTRELNPKSLSSGLDDYPRASHPTDKERHLDLRCWIALAAGVMAELSTLL 616
            |.|..:|.||||:......||||:|.||||||||||||:..|||||||||:||.|.|:::|:..|
Mouse   551 GPVPLSYRWRGRDLALPTLLNPKTLPSGLDDYPRASHPSTAERHLDLRCWVALGARVLSQLAEQL 615

  Fly   617 GKDD--AKYYETASYLTDNVRLNRLHLAPYSEQYADWGLHTDQVKLK-RPPSMAPQQQQRHHHQH 678
            |:.:  |:....|:.|.:...|:.||.||....:||:|.||..|:|| |||.
Mouse   616 GETEAAAELGPLAASLEEPGSLDELHWAPELGVFADFGNHTKAVQLKSRPPQ------------- 667

  Fly   679 YQLPEMQRVTGE-LPTYQFVDSAFGYVSLFPLLLEQLDHDSPYLTKLLNDLRDPEQLWTNYGLRS 742
                .:.||.|. .|..|:|| |.||||||||||:.||..||.|..||:.|.|...||:.:||||
Mouse   668 ----GLVRVVGRPPPRLQYVD-ALGYVSLFPLLLQLLDPSSPRLGPLLDVLADSRHLWSPFGLRS 727

  Fly   743 LSKRSPLYMQRNTEHDPPYWRGPIWININYLAAKALHHYGKIDGPNAALARQIYAELRDNLVGNI 807
            ||..|..|.|||||||||||||.:|:||||||..||||||.::||:...|.::|.|||.|:|.|:
Mouse   728 LSASSLFYKQRNTEHDPPYWRGAVWLNINYLALGALHHYGHVEGPHKVQAAKLYHELRANVVRNV 792

  Fly   808 LRQYKRSGYLWEQYDDTSGEGKGCNPFTGWTATVVLLMAEQF 849
            .:||:.:|:|||||.|..|.|.||.||.|||:.|:|:|||::
Mouse   793 RQQYQATGFLWEQYSDQDGRGMGCRPFQGWTSLVLLIMAEEY 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS1	NP_001245621.1	Glyco_hydro_63N	104..283	CDD:293528	74/201 (37%)
GCS1	NP_001245621.1	Glyco_hydro_63	352..847	CDD:281228	250/505 (50%)
Mogs	NP_065644.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		5/14 (36%)
		Endoplasmic reticulum targeting	3..9
		Required for endoplasmic reticulum targeting. /evidence=ECO:0000250	74..136		28/84 (33%)
		Glyco_hydro_63N	92..267	CDD:293528	70/192 (36%)
		Glyco_hydro_63	349..832	CDD:281228	250/505 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848793
Domainoid	1	1.000	478	1.000	Domainoid score	I419
eggNOG	1	0.900	-	-		E1_KOG2161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4593
Inparanoid	1	1.050	602	1.000	Inparanoid score	I939
Isobase	1	0.950	-	0	Normalized mean entropy	S1986
OMA	1	1.010	-	-		QHG53903
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004064
OrthoInspector	1	1.000	-	-		oto93154
orthoMCL	1	0.900	-	-		OOG6_103455
Panther	1	1.100	-	-	LDO	PTHR10412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R480
SonicParanoid	1	1.000	-	-		X2818
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740