DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS1 and mogs

DIOPT Version :9

Sequence 1:	NP_001245621.1	Gene:	GCS1 / 32073	FlyBaseID:	FBgn0030289	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_001073659.1	Gene:	mogs / 567913	ZFINID:	ZDB-GENE-070112-412	Length:	841	Species:	Danio rerio

Alignment Length:	824	Identity:	376/824 - (45%)
Similarity:	503/824 - (61%)	Gaps:	45/824 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 KWKTMIGCV--------CLAIASYFGYLGYLET----RVNTPFDHQKMVVHAGLE----QPDRYW 105
            |.||.||.|        |:....:|.|..|:.:    ||.| ......|:.|...    .|:|||
Zfish    32 KKKTDIGKVFINISIGLCIFSLIWFFYALYMRSSLARRVVT-LHPSPRVLDANSSSPAVSPERYW 95

  Fly   106 GSYRPLTYFGMKTRDPHSLVMGLMWYTPSNLGPGGQGIRHWCEQGDKLDSYGWTHHDGRSFGVQE 170
            |||||..|||||||.|.|:|.||||.  .........:||.|||||.|..|||..|||.||||||
Zfish    96 GSYRPQVYFGMKTRSPRSVVTGLMWM--HQFAEMDGNLRHTCEQGDHLLGYGWLMHDGVSFGVQE 158

  Fly   171 IQDLPFELKTSFVKYPEGKQYGGDWTARISVR-NTTRAWDKSISLIWYVALDERTNGHIKYVSDD 234
            |.|..|.|.|.||| ..|..:|||||.||:.: :.|......:||::|.:.|.:  |.::...::
Zfish   159 IHDRDFTLTTEFVK-RMGGDHGGDWTWRITAKQHGTALSTPVVSLMFYASTDGQ--GSLQAHVEE 220

  Fly   235 KSPEPGVYGEAQGLGEFQVRF------HAVKGKILHKSYLSTVAPSLAKLKDTL---FSHFRAFA 290
            |:....|.|.::.||.|::.|      .....|....::|.|.:|.|.||.|.:   .:|...|:
Zfish   221 KNRVSSVTGTSEELGNFKITFGKPTAGEGASAKYARYNFLQTRSPGLDKLTDIVKNSLNHKFIFS 285

  Fly   291 DKRGNR--FIGLPGEIVSQNGLPSSNP--EPNFIAIQITAEVDFTLDITYQSTSGFSLGESIPKP 351
            ..:|.:  :..:....|:.:....::|  |.:|:..|:|.:..|.:::.::|.|    ....|..
Zfish   286 PPKGEKRSYFAVDSYKVTNHQNQQNDPKMESDFVVHQVTVQTPFQIEVLFESGS----FRERPNQ 346

  Fly   352 PTGRAYQDSLQAKIAQFEQRFEDRFQLKQKGHSPEEVRFARNALSNLLGGIGYFYGSSRVQSVYT 416
            ..|....|.|:.:...|:::||..|.|:.||.:...::||:.||||:|||:|||:|.|.|||||.
Zfish   347 LVGSVLTDELEKRKVAFDEKFEATFGLQAKGFTSSHIKFAKAALSNMLGGMGYFFGPSVVQSVYN 411

  Fly   417 KNPVPYWKAPLYTAVPSRSFFPRGFLWDEGFHGLLISAWDIDIELDIICHWFDLLNVEGWIPREQ 481
            ::||.|.:.||:||||||||||||||||||||.||:|.||..:..::..||.||:|:||||||||
Zfish   412 EHPVLYPEGPLFTAVPSRSFFPRGFLWDEGFHQLLLSKWDTQLTQEVFAHWLDLINIEGWIPREQ 476

  Fly   482 ILGVEALAKVPEEFVTQRNSNANPPTFFLTLKKLLTSHRAEL-SQNGRLATLERLYPRVQAWFNW 545
            ||..||.:|||.||:.|.|.||||||.||.|::||....||| |....|..|.:||||:|.||.|
Zfish   477 ILDDEARSKVPSEFIVQHNENANPPTLFLALQELLEQLDAELVSSQTMLPFLRKLYPRLQVWFEW 541

  Fly   546 FNTTQRGEVLGTYLWRGRNATTTRELNPKSLSSGLDDYPRASHPTDKERHLDLRCWIALAAGVMA 610
            |||||.|.|..:|.||||:..|...||||:|:||||||||||||:..|||:||.||:.||:||||
Zfish   542 FNTTQVGPVPNSYRWRGRDKDTNLFLNPKTLTSGLDDYPRASHPSADERHVDLYCWMTLASGVMA 606

  Fly   611 ELSTLLGKDDAKYYETASYLTDNVRLNRLHLAPYSEQYADWGLHTDQVKLKRPPSMAPQQQQRHH 675
            .::.:||:....|..|...|::|..||.||.:.....::|:|.||..|.|::.....|..|.||
Zfish   607 NVARILGEPHQLYENTHRSLSNNDLLNELHWSENLHAFSDYGNHTQAVSLQQEKVFVPPGQPRH- 670

  Fly   676 HQHYQLPEMQRVTGELPTYQFVDSAFGYVSLFPLLLEQLDHDSPYLTKLLNDLRDPEQLWTNYGL 740
              .:.:..:.|.....|..|:| :|.|||||||.||..|..|||.:..:|..::|||:|||.|||
Zfish   671 --QFPVARLVRSVRRAPKLQYV-NALGYVSLFPFLLHILTPDSPKIEHILQAIKDPERLWTPYGL 732

  Fly   741 RSLSKRSPLYMQRNTEHDPPYWRGPIWININYLAAKALHHYGKIDGPNAALARQIYAELRDNLVG 805
            ||||:..||||:||||||.|||||||||||||||.:||||||.|:||....|..:|.|||.||:.
Zfish   733 RSLSRADPLYMKRNTEHDAPYWRGPIWININYLAVRALHHYGSIEGPYKEKAATLYQELRTNLMN 797

  Fly   806 NILRQYKRSGYLWEQYDDTSGEGKGCNPFTGWTATVVLLMAEQF 849
            |:.:||..:||:||||:|::|.|:|.:|||||:|..||:|||::
Zfish   798 NVYKQYLETGYIWEQYNDSTGRGQGSHPFTGWSALTVLIMAEKY 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS1	NP_001245621.1	Glyco_hydro_63N	104..283	CDD:293528	78/188 (41%)
GCS1	NP_001245621.1	Glyco_hydro_63	352..847	CDD:281228	266/495 (54%)
mogs	NP_001073659.1	Glyco_hydro_63N	94..>241	CDD:293528	69/151 (46%)
mogs	NP_001073659.1	Glyco_hydro_63	347..839	CDD:281228	266/495 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594337
Domainoid	1	1.000	558	1.000	Domainoid score	I237
eggNOG	1	0.900	-	-		E1_KOG2161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4593
Inparanoid	1	1.050	699	1.000	Inparanoid score	I655
OMA	1	1.010	-	-		QHG53903
OrthoDB	1	1.010	-	-		D162821at33208
OrthoFinder	1	1.000	-	-		FOG0004064
OrthoInspector	1	1.000	-	-		oto39248
orthoMCL	1	0.900	-	-		OOG6_103455
Panther	1	1.100	-	-	LDO	PTHR10412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R480
SonicParanoid	1	1.000	-	-		X2818
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800