DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS1 and SPAC6G10.09

DIOPT Version :9

Sequence 1:	NP_001245621.1	Gene:	GCS1 / 32073	FlyBaseID:	FBgn0030289	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_594106.1	Gene:	SPAC6G10.09 / 2542534	PomBaseID:	SPAC6G10.09	Length:	808	Species:	Schizosaccharomyces pombe

Alignment Length:	899	Identity:	276/899 - (30%)
Similarity:	403/899 - (44%)	Gaps:	227/899 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 FGYLGYLETRVNTPFDHQKMVVHAGLEQPDR------YWGSYRPLTYFGMKTRDPHSLVMGLMWY 131
            ||.|.:|...|         :|...:|..::      .||.|||..|.|::.:.|.||:.||||
pombe    15 FGLLSFLLNCV---------LVSCSVEDIEKAANDSFLWGPYRPNLYVGIRPKIPDSLMTGLMW- 69

  Fly   132 TPSNLGPGGQ--GIRHWCEQGDKLDSYGWTHHDGRSFGVQEIQD--LPFELKTSFVKYPEGKQYG 192
              ||:....:  .:||..|.||.:.::||.|:|.|..|.|.|.|  :..:|:|.|||.||
pombe    70 --SNVDDYARFSKMRHSAEHGDDIGAFGWKHYDVRRGGQQVIDDFLMGIKLETDFVKLPE----- 127

  Fly   193 GDWTARI-SVRNTTRAWDKSISLIWYVALD------ERTNGHIKYV-SDDKSPEPGVYGEAQGLG 249
            |:|..|: .:.......|.:.||.:|..::      .:.| |..:| .:.|:|:         ||
pombe   128 GNWALRVHGIPLPGAPTDLTTSLFFYAYVEGEGKVGTKVN-HANHVYMEGKTPD---------LG 182

  Fly   250 EFQVRF------HAV-------KGKILHKSYLS----------TVAPSLAKLKDTLFSHFRAFAD 291
            :|:::.      |.|       :..::.|.:.:          ..:..:..|.||   ..:..:|
pombe   183 KFRIQTFNRLGEHPVSPASVDLESMVMDKDFFAGFNVKKEGAWRTSELILYLLDT---KMKVISD 244

  Fly   292 KRGNRFI-GLPGEIVSQNGLPSSNPEPNFIAIQITAEVDFTLDITYQSTSGFSLGESIPKPPTGR 355
            |.|...: .|| ...|...||:...|.....||...:.:|..||.:...|...:.|.:    ..:
pombe   245 KEGYESLKDLP-PAYSTLTLPNLPSEEGLQFIQKVFKGEFMFDIVFNYASSKKISEEM----ISQ 304

  Fly   356 AYQDSLQAKIAQFEQRFEDRFQLK-----QKGHSPEEVRFARNALSNLLGGIGYFYGSSRVQSVY 415
            |...:||    :||::|:..|.||     :|.|.    .||..|.|||.|.:|:|.|    .|:.
pombe   305 AIDKNLQ----EFEEKFQATFPLKAPYDTEKAHQ----IFAHTAFSNLFGNVGFFTG----DSIV 357

  Fly   416 TKNPVPY--------------------------WKAPLYTAVPSRSFFPRGFLWDEGFHGLLISA 454
            :|||:..                          .:..|:|.||||..|||||.||||||.|.:..
pombe   358 SKNPIELDDEDYEFMQGFESAAGKLAEGTAFHDIERSLFTIVPSRPHFPRGFYWDEGFHLLPVGL 422

  Fly   455 WDIDIELDIICHWFDLLNVEGWIPREQILGVEALAKVPEEFVTQRNSNANPPTFFLTLKKLLTSH 519
            ||.|..|:|:..||.|:|.:||:.||||||.||.:|||:||.||....|||||..|.||..:  .
pombe   423 WDNDFSLEILKSWFSLVNEDGWVGREQILGEEARSKVPDEFQTQYPDIANPPTLILALKGYI--E 485

  Fly   520 RAELSQNGRLAT-------------------------------LERLYPRVQAWFNWFNTTQRG- 552
            |.: .|.|:|..                               |..|:|.:...:.||..||:|
pombe   486 RLQ-EQQGKLNNRFSGEGEDYSLDDLEYLRSVSISNPEKSVQFLRDLFPLLLRHYEWFRETQKGD 549

  Fly   553 ----------EVLGTYLWRGRNATTTRELNPKSLSSGLDDYPRASHPTDKERHLDLRCWIALAAG 607
                      :|.| |.||||.       ....|:|||||||||..|:..|.|:||..|:.....
pombe   550 FETWERECFSQVEG-YRWRGRT-------YQHCLASGLDDYPRAQPPSTAELHVDLLSWMTSFTR 606

  Fly   608 VMAELSTLLGK-DDAKYYETASYLTDNVRLNRLHLAPYSEQ---YADWGL--HTDQVKLKRPPSM 666
            .:..::..||: ::|:  :.|.|  :|..|..|....:.|:   |.|..:  :.|.:.:
pombe   607 SLHFVAEFLGETEEAE--KLAGY--ENAMLRNLEDNHWDEEVQAYCDSSVDEYDDPINV------ 661

  Fly   667 APQQQQRHHHQHYQLPEMQRVTGELPTYQFVDSAFGYVSLFPLLLEQLDHDSPYLTKLLNDLRDP 731
                    .|:                        |||:|.|::|..|..||..||.||..:||.
pombe   662 --------CHK------------------------GYVTLLPMMLGLLPADSGRLTSLLKLIRDE 694

  Fly   732 EQLWTNYGLRSLSKRSPLYMQRNTEHDPPYWRGPIWININYLAAKALH-HYGKIDGPNAALARQI 795
            .:||:.||:||||.....:   .|..:  |||||||||:|||...:|: :|....|||..|||.|
pombe   695 NELWSPYGIRSLSMNDVYF---GTGEN--YWRGPIWINMNYLILSSLYQNYINTPGPNQNLARSI 754

  Fly   796 YAELRDNLVGNILRQYKRSGYLWEQYDDTSGEGKGCNPFTGWTATVVLLMAEQF 849
            |.|||.|:|.|:...::::|..|||||.|:|:|:....|||||:.||.:|:|.:
pombe   755 YEELRTNVVNNVFENWRQTGIFWEQYDPTTGKGQRTKDFTGWTSLVVNIMSENY 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS1	NP_001245621.1	Glyco_hydro_63N	104..283	CDD:293528	58/213 (27%)
GCS1	NP_001245621.1	Glyco_hydro_63	352..847	CDD:281228	194/574 (34%)
SPAC6G10.09	NP_594106.1	Glyco_hydro_63N	43..251	CDD:293528	61/228 (27%)
SPAC6G10.09	NP_594106.1	Glyco_hydro_63	297..806	CDD:281228	195/582 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	271	1.000	Domainoid score	I331
eggNOG	1	0.900	-	-		E1_KOG2161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	334	1.000	Inparanoid score	I507
OMA	1	1.010	-	-		QHG53903
OrthoFinder	1	1.000	-	-		FOG0004064
OrthoInspector	1	1.000	-	-		oto101067
orthoMCL	1	0.900	-	-		OOG6_103455
Panther	1	1.100	-	-	LDO	PTHR10412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R480
SonicParanoid	1	1.000	-	-		X2818
TreeFam	1	0.960	-	-
	13	12.860