DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS1 and R03E9.2

DIOPT Version :9

Sequence 1:	NP_001245621.1	Gene:	GCS1 / 32073	FlyBaseID:	FBgn0030289	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_509135.3	Gene:	R03E9.2 / 187540	WormBaseID:	WBGene00019843	Length:	619	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	103/553 - (18%)
Similarity:	189/553 - (34%)	Gaps:	186/553 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 FQLKQKGHS--PEEVRFARNAL-------------SNLLGGIGYFY------------------- 406
            |.:::.|.:  |.::....|.:             :.|:.||.||:
Worm   122 FSIEKNGTTILPNQLETIENGIPVVFNGGKLTFKYNQLIVGINYFFHANSSITVVIDSLGSAPNR 186

  Fly   407 GSSRVQSVYTKNPVPYWKAPLYTAVPSRSFFPRGFLWDEGFHGLLISAWDIDIELDIICH-WFDL 470
            .|..:..|.::......|.||.:.  ||.:|  .|..:.|  ....|..|||.::..|.: |.|.
Worm   187 SSDNLTVVISQGDDQILKIPLKSG--SRKYF--SFPSENG--TAFSSEKDIDTQIKSIANSWLDG 245

  Fly   471 LNVEGWIPREQILGVEALAKVPEEFVTQRNSNANPPTFFLTLKKLLTSHRAELSQNGRLATLERL 535
            :|:                .||:||                |::|..::         |..:|..
Worm   246 VNI----------------LVPKEF----------------LERLPKAY---------LEIMEYA 269

  Fly   536 YPRVQAWFNWFNTTQRGEVLGTYLWRGRNATTTREL-NPKSLSSGLDDYPRASHPTD---KERHL 596
            |..|.   |..|.....:::|.|    .|.|..:.: ..:|.:.|...:.....|..   |..|:
Worm   270 YAYVA---NSLNFIPSAKLIGQY----ENFTVDQTMFFIQSRNEGFTSFDDQVFPLMTLLKLNHI 327

  Fly   597 D----LRCWIAL------------AAGVMAE--------------LST---LLGKDDAKYYETAS 628
            |    |..|::.            .||::.|              |||   ::.||: ::.|...
Worm   328 DTLNILNSWMSTINELGYMGNRFSEAGIVLEKIQSPLLFQLVKEALSTQPKIITKDN-QFIEKLE 391

  Fly   629 YLTDNVRLNRLHLAPYSEQYADWGLHTDQVKLKRPPSMAPQQ----------------------- 670
            |:.:|...|  .:.|.......|..|:..:....|.:...:.
Worm   392 YIAENTWKN--SIGPGRLLDVKWMGHSRGIFQLEPATKTGESSFELFCLIGDMCRIMNKVYERVD 454

  Fly   671 ------QQRHHHQHYQLP-----EMQRVTGELPTYQFVDSAFGYVSLFPLLLEQLDHDSPYLTKL 724
                  |||:......||     |:|:. |:|.|.:|..::..:..:...|:.:...|   ||:.
Worm   455 EYDSKWQQRYLDFEAALPKYWNKELQQY-GDLETGKFKPNSSSHALITLSLVNETSED---LTRF 515

  Fly   725 LNDLRDPEQLWTNYGLRSLSKRSPLYMQRNTEHDPPYWRGPIWININYLAAKALHHYGKIDGPNA 789
            |.::    |...|:        :||.:|.:.:..       :.::.|||..::|..|.....|..
Worm   516 LQNI----QTDNNF--------TPLGLQMSEDDG-------VSVSANYLLLRSLQFYALQSSPAQ 561

  Fly   790 ALARQIYAELRDNLVGNILRQYKRSGYLWEQYD 822
            .::.|:|:.|::||...|.|.|:.....:.::|
Worm   562 EMSLQMYSILKNNLAAAIARAYRPEKIFYGKFD 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS1	NP_001245621.1	Glyco_hydro_63N	104..283	CDD:293528
GCS1	NP_001245621.1	Glyco_hydro_63	352..847	CDD:281228	103/553 (19%)
R03E9.2	NP_509135.3	Trehalase	<543..616	CDD:388423	15/52 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10412
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100