DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS1 and mogs-1

DIOPT Version :9

Sequence 1:	NP_001245621.1	Gene:	GCS1 / 32073	FlyBaseID:	FBgn0030289	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_001076681.1	Gene:	mogs-1 / 177998	WormBaseID:	WBGene00008775	Length:	796	Species:	Caenorhabditis elegans

Alignment Length:	808	Identity:	304/808 - (37%)
Similarity:	444/808 - (54%)	Gaps:	90/808 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 MIGCVCLAIASYFGYLGYLETRVNTPFDHQKMVVHAGLEQPDRYWGSYRPLTYFGMKTRDPHSLV 125
            |:|..|..:...:.|.. ||.....|        :...|.....||:|||..|||::||.|.|.:
Worm    54 MLGAGCFILLHLYLYPN-LEKVAPLP--------NIDPENAPYTWGTYRPHMYFGLRTRSPMSPL 109

  Fly   126 MGLMWYTPSNL--GPGGQGIRHWCEQGDKLDSYGWTHHDGRSFGVQEIQDL-PFELKTSFVKYPE 187
            .|:|||...|.  .|   .|||||.|.|:|..|.|...|||.||.|.|.:. ...::|.::....
Worm   110 FGMMWYEQPNTIQRP---HIRHWCNQDDRLPGYYWYEADGRHFGKQNISEAHKGVIQTDWINDAN 171

  Fly   188 GKQYGGDWTARISVRNTTRAWDKSISLIWYVALDE-----RTNGHIKYVSDDKSPEPGVYGEAQG 247
            |      :.||:.:   ..|..:..::|.|::..|     |...|:..|         .:|..:.
Worm   172 G------FAARVKL---NMAPGRRYNVILYLSAQEIGTRFRLGKHLSDV---------FHGYNEL 218

  Fly   248 LGEFQVRFHA---VKGKILHKSYLSTVAPSLAKLKDTLFSHFRAFADKRGNRFIGLPGE----IV 305
            ||:|.:....   .|.:..|...|:.....:.:..|.:..:.:|:         ..|.:    |:
Worm   219 LGKFTMSLRLKDNTKLQTSHSVMLTDEKIPIDRYHDFVVDNTQAY---------NAPNQPLNYIL 274

  Fly   306 SQNGLPSSNPEPNFIAIQIT--AEVDFTLDITYQSTSGFSLGESIPKPPTGRAYQDSLQAKIAQF 368
            ::.   .::.|..|||:|:.  ::.:|.:.:..:...|.       ||   ..:.:.|:.:...|
Worm   275 NEK---HNDEEGKFIAVQLNLGSQAEFDIILQTEKLKGM-------KP---EEFTNILRIRSYNF 326

  Fly   369 EQRFEDRFQLKQKGHSPEEVRFARNALSNLLGGIGYFYGSSRVQSVYTKNPVPYWKAPLYTAVPS 433
            .:::|:.|||..|.::..:::.|:.:|||:||.:||:||.:||  ::.....||....|::||||
Worm   327 NKKYENVFQLAGKNYTKTQLKMAKVSLSNMLGSVGYWYGHNRV--LFNGIVQPYGPHVLFSAVPS 389

  Fly   434 RSFFPRGFLWDEGFHGLLISAWDIDIELDIICHWFDLLNVEGWIPREQILGVEALAKVPEEFVTQ 498
            |.|||||||||||||.:||...|..:.|:.|..|.:.::..||||||.|:|.||.||||.||:.|
Worm   390 RPFFPRGFLWDEGFHQMLIRKMDSKMTLEAIASWMNAMDTSGWIPREMIVGSEAEAKVPAEFIPQ 454

  Fly   499 RNSNANPPTFFLTLKKLLTSHRAELSQNGRLA-TLERLYPRVQAWFNWFNTTQRGEVLGTYLWRG 562
            :|..|||||.|..:.||:...:..    ||.| .|:.||||::.||:|...||.|....||.|||
Worm   455 KNDVANPPTLFYVMDKLVNDEKTV----GRYAGILKLLYPRLEKWFHWIRITQSGPTRTTYRWRG 515

  Fly   563 RNATTTRELNPKSLSSGLDDYPRASHPTDKERHLDLRCWIALAAGVMAELSTLLGKDDAKYYETA 627
            ||.|...|||||:|||||||:||||||:|.|.|||||||:|||:.|:..|:...| .||.|..||
Worm   516 RNETIKTELNPKTLSSGLDDFPRASHPSDLEYHLDLRCWLALASRVLNRLAKSYG-TDADYQRTA 579

  Fly   628 SYLTDNVRLNRL---HLAPYSEQYADWGLHTDQVKLKRPPSMAPQQQQRHHHQHYQLPEMQRVTG 689
            ..:.:....:.|   |.:..::.:.|:|.|:..|.|...|:....:|.          |.||||.
Worm   580 KAMEELNNFDSLVKDHWSEEAQGFFDYGKHSFDVALSPVPTPGSPRQF----------EYQRVTS 634

  Fly   690 ELPTYQFVDSAFGYVSLFPLLLEQLDHDSPYLTKLLNDLRDPEQLWTNYGLRSLSKRSPLYMQRN 754
            ..|:|..|..||||.:|||::|:.:...||.|..:|:.:|||:.|||||||||:|:.||.||.||
Worm   635 RAPSYTLVSDAFGYNNLFPMMLKLIPSKSPILKSMLDKIRDPKILWTNYGLRSISRSSPYYMARN 699

  Fly   755 TEHDPPYWRGPIWININYLAAKALHHYGKIDGPNAALARQIYAELRDNLVGNILRQYKRSGYLWE 819
            ||||||||||.||||:||:...:|.||....||....|..|::|||.|||.|:..|::::|:|||
Worm   700 TEHDPPYWRGYIWINVNYMVLSSLRHYADQPGPYRENAENIFSELRANLVKNLATQFQKTGFLWE 764

  Fly   820 QYDDTSGEGKGCNPFTGWTATVVLLMAE 847
            .|||.:|||:||:|||||::.::|:|::
Worm   765 NYDDRTGEGRGCHPFTGWSSLILLIMSD 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS1	NP_001245621.1	Glyco_hydro_63N	104..283	CDD:293528	54/189 (29%)
GCS1	NP_001245621.1	Glyco_hydro_63	352..847	CDD:281228	230/498 (46%)
mogs-1	NP_001076681.1	Glyco_hydro_63N	89..253	CDD:293528	53/184 (29%)
mogs-1	NP_001076681.1	Glyco_hydro_63	310..792	CDD:281228	232/508 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166039
Domainoid	1	1.000	465	1.000	Domainoid score	I226
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4593
Inparanoid	1	1.050	520	1.000	Inparanoid score	I684
Isobase	1	0.950	-	0	Normalized mean entropy	S1986
OMA	1	1.010	-	-		QHG53903
OrthoDB	1	1.010	-	-		D162821at33208
OrthoFinder	1	1.000	-	-		FOG0004064
OrthoInspector	1	1.000	-	-		oto20227
orthoMCL	1	0.900	-	-		OOG6_103455
Panther	1	1.100	-	-	LDO	PTHR10412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R480
SonicParanoid	1	1.000	-	-		X2818
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890