DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kap3 and kifap3b

DIOPT Version :9

Sequence 1:	NP_727512.3	Gene:	Kap3 / 32071	FlyBaseID:	FBgn0028421	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_001137517.1	Gene:	kifap3b / 561489	ZFINID:	ZDB-GENE-030131-2219	Length:	772	Species:	Danio rerio

Alignment Length:	898	Identity:	364/898 - (40%)
Similarity:	525/898 - (58%)	Gaps:	148/898 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 DDAKFIKKRWKGGSIEPHPTDKALIVNYQLEATVFGEPNNPMIEEKKHCQKIIRLRSLNAKTDPA 162
            |:.:::::|.:.|.|:.|||:|||:|.|::||::.||..|...||||.||||||||||||.||.:
Zfish     4 DETQYLQRRCRIGDIDVHPTEKALVVYYEVEASILGETGNARHEEKKDCQKIIRLRSLNASTDIS 68

  Fly   163 ALAREVVEKCDLIHKSQLNDVEQIIFYLKNRKDNASNDIPDNNTHSRRSAALHTSHTRSSARSHS 227
            |||::|||:|.|||.|:|.:||.::.||:|||.      |......:...|       ...|...
Zfish    69 ALAKKVVEECKLIHPSKLKEVEHLLLYLQNRKK------PSTKLEKKEKKA-------QKPRELL 120

  Fly   228 SVAAMTSSTGSGGGSTGASNGVSNALSAATPTADVSINNIDEYVELLYEELGERIRGSAMILQMA 292
            ....|...                        .:.:||.|:||:|||||.:.|:||||.:||.:|
Zfish   121 LFEGMEID------------------------EEANINKIEEYIELLYESIPEKIRGSTLILHLA 161

  Fly   293 RNPDNLEELEKNEACLSALSRVLREDWRKSLDLSTNIIYIFFCFSTYTKFHPLIVQYKIGSLCMD 357
            |||||||||..||..|.||:|||||||:.|::|:|.|||:|||||::::||.||..||||:|||:
Zfish   162 RNPDNLEELLHNETALGALARVLREDWKHSVELATTIIYVFFCFSSFSQFHGLITHYKIGALCMN 226

  Fly   358 VIDYELRRYETMRNELDVRKQPNGSSTPHSAKASKEKLNRSTDDFLDIMNEEKPKEMEPPRRRIP 422
            ||::||::|:..::||                   ||.:::.|:..|
Zfish   227 VIEHELKKYDLWQDEL-------------------EKKSKACDEDPD------------------ 254

  Fly   423 ELKQRPKSGNWSSFHGSMSSSLIKSQILNSSYHESLCAGGSPGGDTPAVPAEQKAQSNESLDRND 487
                                                                     |.||
Zfish   255 ---------------------------------------------------------NHSL---- 258

  Fly   488 PKVKKEEIDRLNKQLKIFAKKQEQLLRVAFYLLLNMAENVKLEEKMRRKHIVKMLVKALDRQNID 552
                ::|.::..|:.:....|||||||||||||||::|:.:.|.|||.|:||.:|||:|||:|.:
Zfish   259 ----RKEHEKTFKKYQSLLVKQEQLLRVAFYLLLNLSEDTRTELKMRNKNIVHLLVKSLDRENEE 319

  Fly   553 LLMLVSTFLKKLSIVGDNKDEMGALNIVAKLPRLFQSTHTDLVQVTLKLVFNLSFDGGLRRKMIA 617
            ||:||.:|||||||..:||::|..:::|.||..|....|.||:.|||:|:.|||||.|||.||:.
Zfish   320 LLVLVVSFLKKLSIFLENKNDMAEMDVVEKLAHLVPCEHEDLMNVTLRLLHNLSFDTGLRTKMVH 384

  Fly   618 AGYLPMLVMFINDEKHHGIAVKILYHMSLDDKVKGMFTQTECVQMATDAIILNLNVKVDLDLIAL 682
            .|.||.|...:.|:.|..:.::||||:|:|||.|.||..|:|:......:..:...::|.:||:.
Zfish   385 VGLLPKLTALLGDDTHKLVVMRILYHISVDDKSKSMFAYTDCIPQLMQMLFEHGEERIDTELISF 449

  Fly   683 CINLSLNRRNAQIMVEGQRLHSLMDRAFKYQDALLMKLLRNLSQHES-LQLQFIDYVGDLARILT 746
            ||||:.|:.|:|||.||..|..||.||.|.:|.||||::||:|||:. |:..|||||||||..:.
Zfish   450 CINLAANKTNSQIMCEGNGLKMLMRRALKLKDPLLMKMIRNISQHDGPLKQLFIDYVGDLAAQIK 514

  Fly   747 ICDDEAFIVECLGILGNLALTDLDYSQILQNFQLIPWIRQILLPCARMDDLVLDTIVYLGTCACD 811
            ...||.|::||||.:.||.:.|||:..:|:.:.|:|:::..|.|.:..||::|:.::.:||.:.|
Zfish   515 KEGDEEFVIECLGTMANLTIPDLDWELLLKEYNLVPFLKDHLKPGSAEDDMILEVVIMIGTVSMD 579

  Fly   812 ELCALLFCRAKVVISLIELLKAKQEDDEIVLQIIFVFQQILRHESTREYMIKETESAAYLIDLMH 876
            :.||::..::.::.:|||||.|:|||||.|.|||:||.|::.|::||:.:||:|::.||||||||
Zfish   580 DSCAVMLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKDTQAPAYLIDLMH 644

  Fly   877 DKNEEIRKVCDYCLDIIAISDSEWAKRIKLEKFRNHNSQWLCMVESQQDQDNEQDYADQEDECDN 941
            |||.|||:|||..|||||..|.||.|:|:.||||.||||||.||||:|.:|.|......:.|...
Zfish   645 DKNVEIRQVCDNTLDIIAEYDEEWGKKIQSEKFRWHNSQWLEMVESRQMEDGEPYMYGDDPEALE 709

  Fly   942 DLDTYLRSEYLDN------CDLYNDNADNDSNSNSNHSNNNPASPAMSTYSRP 988
            ..|.:..::.:.|      .|.|:.  .:..|.:.|..|.:...||.:...||
Zfish   710 QPDLFYSTDGMMNPEPGISPDFYSQ--FHPQNGDFNACNGSDGRPATAYGFRP 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap3	NP_727512.3	KAP	107..957	CDD:253396	353/856 (41%)
		ARM	531..632	CDD:237987	53/100 (53%)
		ARM	786..894	CDD:237987	54/107 (50%)
kifap3b	NP_001137517.1	KAP	16..713	CDD:253396	351/835 (42%)
		ARM	304..397	CDD:237987	48/92 (52%)
		TIM_phosphate_binding	<509..608	CDD:304361	37/98 (38%)
		ARM	<579..663	CDD:237987	48/83 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580880
Domainoid	1	1.000	517	1.000	Domainoid score	I296
eggNOG	1	0.900	-	-		E1_KOG1222
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1185
OMA	1	1.010	-	-		QHG56928
OrthoDB	1	1.010	-	-		D247183at33208
OrthoFinder	1	1.000	-	-		FOG0006181
OrthoInspector	1	1.000	-	-		otm25160
orthoMCL	1	0.900	-	-		OOG6_105044
Panther	1	1.100	-	-	O	PTHR15605
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4460
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770