Protein Alignment Kap3 and KIFAP3

DIOPT Version :9

• Sequence 1: NP_727512.3
• Gene: Kap3 / 32071
• FlyBaseID: FBgn0028421
• Length: 1038
• Species: Drosophila melanogaster
• Sequence 2: XP_024309954.1
• Gene: KIFAP3 / 22920
• HGNCID: 17060
• Length: 807
• Species: Homo sapiens
• Alignment Length: 909
• Identity: 381/909 - (41%)
• Similarity: 544/909 - (59%)
• Gaps: 157/909 - (17%)

  Fly   101 KFIKKRWKGGSIEPHPTDKALIVNYQLEATVFGEPNNPMIEEKKHCQKIIRLRSLNAKTDPAALA 165
            |.|.::.|||:|:.||::|||||:|::|||:.||..:||:.|:|.|||||||:||||.||..:||
Human    22 KAITRKVKGGNIDVHPSEKALIVHYEVEATILGEMGDPMLGERKECQKIIRLKSLNANTDITSLA 86

  Fly   166 REVVEKCDLIHKSQLNDVEQIIFYLKNRKDNASNDIPDNNTHSRRSAALHTSHTRSSARSHSSVA 230
            |:|||:|.|||.|:||:|||:::||:||:|:.|..              ......|..:......
Human    87 RKVVEECKLIHPSKLNEVEQLLYYLQNRRDSLSGK--------------EKKEKSSKPKDPPPFE 137

  Fly   231 AMTSSTGSGGGSTGASNGVSNALSAATPTADVSINNIDEYVELLYEELGERIRGSAMILQMARNP 295
            .|            ..:.|:|            ||::|||:|||||::.:::||||:|||:||||
Human   138 GM------------EIDEVAN------------INDMDEYIELLYEDIPDKVRGSALILQLARNP 178

  Fly   296 DNLEELEKNEACLSALSRVLREDWRKSLDLSTNIIYIFFCFSTYTKFHPLIVQYKIGSLCMDVID 360
            ||||||..||..|.||:|||||||::|::|:|||||||||||::::||.||..||||:|||::||
Human   179 DNLEELLLNETALGALARVLREDWKQSVELATNIIYIFFCFSSFSQFHGLITHYKIGALCMNIID 243

  Fly   361 YELRRYETMRNELDVRKQPNGSSTPHSAKASKEKLNRSTDDFLDIMNEEKPKEMEPPRRRIPELK 425
            :||:|:|..:.||                 ||:|               |..:.:|
Human   244 HELKRHELWQEEL-----------------SKKK---------------KAVDEDP--------- 267

  Fly   426 QRPKSGNWSSFHGSMSSSLIKSQILNSSYHESLCAGGSPGGDTPAVPAEQKAQSNESLDRNDPKV 490
                                ::|.|...|.::.
Human   268 --------------------ENQTLRKDYEKTF-------------------------------- 280

  Fly   491 KKEEIDRLNKQLKIFAKKQEQLLRVAFYLLLNMAENVKLEEKMRRKHIVKMLVKALDRQNIDLLM 555
                     |:.:....|||||||||.|||||:||:.:.|.|||.|:||.||||||||.|.:||:
Human   281 ---------KKYQGLVVKQEQLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLI 336

  Fly   556 LVSTFLKKLSIVGDNKDEMGALNIVAKLPRLFQSTHTDLVQVTLKLVFNLSFDGGLRRKMIAAGY 620
            ||.:|||||||..:||::|..::||.||.::....|.||:.:||:|:.|||||.|||.||:..|.
Human   337 LVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGL 401

  Fly   621 LPMLVMFINDEKHHGIAVKILYHMSLDDKVKGMFTQTECVQMATDAIILNLNVKVDLDLIALCIN 685
            ||.|...:.::.:..||:.:|||:|:||:.|.||..|:|:......:....:.::||:||:.|||
Human   402 LPKLTALLGNDNYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCIN 466

  Fly   686 LSLNRRNAQIMVEGQRLHSLMDRAFKYQDALLMKLLRNLSQHES-LQLQFIDYVGDLARILTICD 749
            |:.|:||.|::.||..|..||.||.|::|.||||::||:|||:. .:..|||||||||..::..:
Human   467 LAANKRNVQLICEGNGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDE 531

  Fly   750 DEAFIVECLGILGNLALTDLDYSQILQNFQLIPWIRQILLPCARMDDLVLDTIVYLGTCACDELC 814
            :|.|::||||.|.||.:.|||:..:|:.::|:|:::..|.|.|..|||||:.::.:||.:.|:.|
Human   532 EEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSC 596

  Fly   815 ALLFCRAKVVISLIELLKAKQEDDEIVLQIIFVFQQILRHESTREYMIKETESAAYLIDLMHDKN 879
            |.|..::.::.:|||||.|:|||||.|.|||:||.|::.|::||:.:||||::.|||||||||||
Human   597 AALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKN 661

  Fly   880 EEIRKVCDYCLDIIAISDSEWAKRIKLEKFRNHNSQWLCMVESQQDQDNEQD-YADQEDE---CD 940
            .|||||||..|||||..|.||||:|:.||||.||||||.||||:|..::||. |.|...|   .:
Human   662 NEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQYLYGDDRIEPYIHE 726

  Fly   941 NDL----------DTYLRSEYLDNCDLYNDNADNDSNSNSNHSNNNPASPAMSTYSRPLSTYRR 994
            .|:          |..:.||...:.|.:||....:.:....||  .|.|..|..:.:|:....|
Human   727 GDILERPDLFYNSDGLIASEGAISPDFFNDYHLQNGDVVGQHS--FPGSLGMDGFGQPVGILGR 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap3	NP_727512.3	KAP	107..957	CDD:253396	369/864 (43%)
		ARM	531..632	CDD:237987	53/100 (53%)
		ARM	786..894	CDD:237987	60/107 (56%)
KIFAP3	XP_024309954.1	KAP	28..735	CDD:253396	366/846 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147344
Domainoid	1	1.000	451	1.000	Domainoid score	I513
eggNOG	1	0.900	-	-		E1_KOG1222
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7799
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1601
Isobase	1	0.950	-	0.993157	Normalized mean entropy	S3709
OMA	1	1.010	-	-		QHG56928
OrthoDB	1	1.010	-	-		D247183at33208
OrthoFinder	1	1.000	-	-		FOG0006181
OrthoInspector	1	1.000	-	-		oto89113
orthoMCL	1	0.900	-	-		OOG6_105044
Panther	1	1.100	-	-	LDO	PTHR15605
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3383
SonicParanoid	1	1.000	-	-		X4460
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750