DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kap3 and Kifap3

DIOPT Version :9

Sequence 1:	NP_727512.3	Gene:	Kap3 / 32071	FlyBaseID:	FBgn0028421	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	XP_006496742.1	Gene:	Kifap3 / 16579	MGIID:	107566	Length:	809	Species:	Mus musculus

Alignment Length:	916	Identity:	380/916 - (41%)
Similarity:	550/916 - (60%)	Gaps:	163/916 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 NDDAKFIKKRWKGGSIEPHPTDKALIVNYQLEATVFGEPNNPMIEEKKHCQKIIRLRSLNAKTDP 161
            :|..|.:.::.|||:|:.||::|||||.|::|||:.||..:||:.|:|.|||||||:||||.||.
Mouse    19 DDVPKAVTRKVKGGNIDVHPSEKALIVQYEVEATILGEMGDPMLGERKECQKIIRLKSLNANTDI 83

  Fly   162 AALAREVVEKCDLIHKSQLNDVEQIIFYLKNRKDNASNDIPDNNTHSRRSAALHTSHTRSSARSH 226
            .:|||:|||:|.|||.|:|::|||:::||:||:|:    :|......:          .|..:..
Mouse    84 TSLARKVVEECKLIHPSKLSEVEQLLYYLQNRRDS----LPGKEKKEK----------SSKPKDP 134

  Fly   227 SSVAAMTSSTGSGGGSTGASNGVSNALSAATPTADVSINNIDEYVELLYEELGERIRGSAMILQM 291
            .....|            ..:.|:|            ||::|||:|||||::.:::||||:|||:
Mouse   135 PPFEGM------------EIDEVAN------------INDMDEYIELLYEDIPDKVRGSALILQL 175

  Fly   292 ARNPDNLEELEKNEACLSALSRVLREDWRKSLDLSTNIIYIFFCFSTYTKFHPLIVQYKIGSLCM 356
            ||||||||||..||..|.||:|||||||::|::|:|||||||||||:::.||.||..||||:|||
Mouse   176 ARNPDNLEELLLNETALGALARVLREDWKQSVELATNIIYIFFCFSSFSHFHGLITHYKIGALCM 240

  Fly   357 DVIDYELRRYETMRNELDVRKQPNGSSTPHSAKASKEKLNRSTDDFLDIMNEEKPKEMEPPRRRI 421
            ::||:||:|:|..:.||                 ||:|  ::.|:.|:
Mouse   241 NIIDHELKRHELWQEEL-----------------SKKK--KAVDEDLE----------------- 269

  Fly   422 PELKQRPKSGNWSSFHGSMSSSLIKSQILNSSYHESLCAGGSPGGDTPAVPAEQKAQSNESLDRN 486
                                                                      |::|
Mouse   270 ----------------------------------------------------------NQTL--- 273

  Fly   487 DPKVKKEEIDRLNKQLKIFAKKQEQLLRVAFYLLLNMAENVKLEEKMRRKHIVKMLVKALDRQNI 551
                 :::.|:..|:.:....|||||||||.|||||:||:.:.|.|||.|:||.||||||||.|.
Mouse   274 -----RKDYDKTFKKYQGLVVKQEQLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNF 333

  Fly   552 DLLMLVSTFLKKLSIVGDNKDEMGALNIVAKLPRLFQSTHTDLVQVTLKLVFNLSFDGGLRRKMI 616
            :||:||.:|||||||..:||::|..::||.||.::....|.||:.:||:|:.|||||.|||.||:
Mouse   334 ELLILVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMV 398

  Fly   617 AAGYLPMLVMFINDEKHHGIAVKILYHMSLDDKVKGMFTQTECVQMATDAIILNLNVKVDLDLIA 681
            ..|.||.|...:.:|.:..||:.:|||:|:||:.|.||..|:|:......:....:.::||:||:
Mouse   399 QVGLLPKLTALLGNENYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELIS 463

  Fly   682 LCINLSLNRRNAQIMVEGQRLHSLMDRAFKYQDALLMKLLRNLSQHES-LQLQFIDYVGDLARIL 745
            .||||:.|:||.|::.||..|..||.||.|.:|.||||::||:|||:. .:..|||||||||..:
Mouse   464 FCINLAANKRNVQLICEGNGLKMLMKRALKLKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQI 528

  Fly   746 TICDDEAFIVECLGILGNLALTDLDYSQILQNFQLIPWIRQILLPCARMDDLVLDTIVYLGTCAC 810
            :..::|.|::||||.|.||.:.|||:..:|:.::|:|:::..|.|.|..|||||:.::.:||.:.
Mouse   529 SSDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPFLKDKLKPGAAEDDLVLEVVIMIGTVSM 593

  Fly   811 DELCALLFCRAKVVISLIELLKAKQEDDEIVLQIIFVFQQILRHESTREYMIKETESAAYLIDLM 875
            |:.||.|..::.::.:|||||.|:|||||.|.|||:||.|::.|::||:.:||||::.|||||||
Mouse   594 DDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLM 658

  Fly   876 HDKNEEIRKVCDYCLDIIAISDSEWAKRIKLEKFRNHNSQWLCMVESQQDQDNEQDYADQEDECD 940
            ||||.|||||||..|||||..|.||||:|:.||||.||||||.||||:|..::|| |...:|.
Mouse   659 HDKNNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQLDESEQ-YLYGDDR-- 720

  Fly   941 NDLDTYL-RSEYLDNCDLY--------NDNADNDSNSNSNHSNNN--------PASPAMSTYSRP 988
              ::.|: ..:.|:..||:        ::.|.:....|..|..|.        |.|..|..:.:|
Mouse   721 --IEPYIHEGDILERPDLFYNSDGLITSEGAISPDFFNDFHLQNGDVVGQHAFPGSLGMDGFGQP 783

  Fly   989 LSTYRR 994
            |....|
Mouse   784 LGILGR 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap3	NP_727512.3	KAP	107..957	CDD:253396	366/851 (43%)
		ARM	531..632	CDD:237987	53/100 (53%)
		ARM	786..894	CDD:237987	60/107 (56%)
Kifap3	XP_006496742.1	KAP	29..736	CDD:253396	366/851 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837277
Domainoid	1	1.000	451	1.000	Domainoid score	I508
eggNOG	1	0.900	-	-		E1_KOG1222
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7799
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1588
Isobase	1	0.950	-	0.993157	Normalized mean entropy	S3709
OMA	1	1.010	-	-		QHG56928
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006181
OrthoInspector	1	1.000	-	-		oto92681
orthoMCL	1	0.900	-	-		OOG6_105044
Panther	1	1.100	-	-	LDO	PTHR15605
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3383
SonicParanoid	1	1.000	-	-		X4460
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740