DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kap3 and kifap3

DIOPT Version :9

Sequence 1:	NP_727512.3	Gene:	Kap3 / 32071	FlyBaseID:	FBgn0028421	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	XP_012815844.2	Gene:	kifap3 / 100038301	XenbaseID:	XB-GENE-942612	Length:	794	Species:	Xenopus tropicalis

Alignment Length:	930	Identity:	386/930 - (41%)
Similarity:	554/930 - (59%)	Gaps:	179/930 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 NDDAKFIKKRWKGGSIEPHPTDKALIVNYQLEATVFGEPNNPMIEEKKHCQKIIRLRSLNAKTDP 161
            :|||:|:|::.|.|:|:.|||:|||:|:|::|||:.||..:.|:.|:|.|||||||:||||.||.
Frog     3 SDDARFLKRKVKEGNIDVHPTEKALVVHYEVEATILGERGDTMLGERKECQKIIRLKSLNANTDI 67

  Fly   162 AALAREVVEKCDLIHKSQLNDVEQIIFYLKNRKDNASNDIPDNNTHSRRSAALHTSHTRSSARSH 226
            ::|||:||::|.|||.|:|.:|||:::||:||::
Frog    68 SSLARKVVDECKLIHPSKLAEVEQLLYYLQNRRE------------------------------- 101

  Fly   227 SSVAAMTSSTGSGGGSTGASNGVSNALSAATPTADV------SINNIDEYVELLYEELGERIRGS 285
                        |..|.......||......|...:      :||::|||:|||||.:.:::|||
Frog   102 ------------GLQSKEKKEKKSNKPKDPPPFEGMEIDEVANINDMDEYIELLYENIADKVRGS 154

  Fly   286 AMILQMARNPDNLEELEKNEACLSALSRVLREDWRKSLDLSTNIIYIFFCFSTYTKFHPLIVQYK 350
            |:|||:||||||||||..||..|.||:|||||||::|::|:|||||||||||::::||.||..||
Frog   155 ALILQLARNPDNLEELLLNETALGALARVLREDWKQSVELATNIIYIFFCFSSFSQFHGLITHYK 219

  Fly   351 IGSLCMDVIDYELRRYETMRNELDVRKQPNGSSTPHSAKASKEKLNRSTDDFLDIMNEEKPKEME 415
            ||:|||::||:||:|::..:.||                 ||:|  |:.||
Frog   220 IGALCMNIIDHELKRHDLWQEEL-----------------SKKK--RAVDD-------------- 251

  Fly   416 PPRRRIPELKQRPKSGNWSSFHGSMSSSLIKSQILNSSYHESLCAGGSPGGDTPAVPAEQKAQSN 480
                                                                    .||     |
Frog   252 --------------------------------------------------------DAE-----N 255

  Fly   481 ESLDRNDPKVKKEEIDRLNKQLKIFAKKQEQLLRVAFYLLLNMAENVKLEEKMRRKHIVKMLVKA 545
            ::|        |:|.::..|:.:....|||||||||.|||||:||:.:.|.|||.|:||.|||||
Frog   256 QNL--------KKEYEKTYKKYQGLLVKQEQLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKA 312

  Fly   546 LDRQNIDLLMLVSTFLKKLSIVGDNKDEMGALNIVAKLPRLFQSTHTDLVQVTLKLVFNLSFDGG 610
            |||.|.:||:||.:|||||||..:||::|..::|:.||.:|....|.||:.:||:|:.|||||.|
Frog   313 LDRDNFELLILVVSFLKKLSIFLENKNDMAEMDIIEKLSKLVPCEHEDLLNITLRLLLNLSFDTG 377

  Fly   611 LRRKMIAAGYLPMLVMFINDEKHHGIAVKILYHMSLDDKVKGMFTQTECVQMATDAIILNLNVKV 675
            ||.||:..|.||.|.:.:::|.:..|.:.||||:|:||:.|.||..|:|:......:..:...:|
Frog   378 LRNKMVQVGLLPKLTVLLDNENYKQIVMCILYHISMDDRFKSMFAYTDCIPQLMKMLFESSEERV 442

  Fly   676 DLDLIALCINLSLNRRNAQIMVEGQRLHSLMDRAFKYQDALLMKLLRNLSQHES-LQLQFIDYVG 739
            ||:||:.||||:.|:||||::.||..|..||.:|.|::|.||||::||:|||:. .:..||||||
Frog   443 DLELISFCINLAANKRNAQLICEGNGLKMLMKKALKFKDPLLMKMIRNISQHDGPTKTLFIDYVG 507

  Fly   740 DLARILTICDDEAFIVECLGILGNLALTDLDYSQILQNFQLIPWIRQILLPCARMDDLVLDTIVY 804
            |||..:|..::|.|::||||.|.||.:||||:..:|:.::|:|:::..|.|.:..|||||:.::.
Frog   508 DLAAQITNDEEEEFVIECLGTLANLTITDLDWELVLKEYKLVPYLKDKLKPGSAEDDLVLEVVIM 572

  Fly   805 LGTCACDELCALLFCRAKVVISLIELLKAKQEDDEIVLQIIFVFQQILRHESTREYMIKETESAA 869
            :||.:.|:.||.|..::.::.:|||||.|:|||||.|.||::||.|::.|::||:.:||:|::.|
Frog   573 IGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIVYVFYQMVFHQATRDVIIKDTQAPA 637

  Fly   870 YLIDLMHDKNEEIRKVCDYCLDIIAISDSEWAKRIKLEKFRNHNSQWLCMVESQQDQDNEQD-YA 933
            ||||||||||.|||||||..|||||..|.||||:|:.||||.||||||.||||:|..:|||. |.
Frog   638 YLIDLMHDKNAEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQLDENEQYLYG 702

  Fly   934 DQEDE---CDNDL----DTYLRSEYL---DNC---DLYNDNADNDSNSNSNHSNNN--------- 976
            |:..|   .:.|:    |.|..:|.|   |..   |.:|:....:.:....||.|.
Frog   703 DEPIEPFIHERDILERPDLYYSAEGLIPSDGVVSPDFFNEFHQQNGDLMGQHSFNTGMGEDAFGQ 767

  Fly   977 ----PASPAMSTYSRPLSTY 992
                |..|:.:...||...|
Frog   768 HTAMPGRPSTAYGYRPDEAY 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap3	NP_727512.3	KAP	107..957	CDD:253396	371/870 (43%)
		ARM	531..632	CDD:237987	53/100 (53%)
		ARM	786..894	CDD:237987	57/107 (53%)
kifap3	XP_012815844.2	KAP	13..721	CDD:253396	366/852 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	515	1.000	Domainoid score	I311
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7799
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247183at33208
OrthoFinder	1	1.000	-	-		FOG0006181
OrthoInspector	1	1.000	-	-		oto102968
Panther	1	1.100	-	-	LDO	PTHR15605
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3383
SonicParanoid	1	1.000	-	-		X4460
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190