DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gapvd1 and VPS9

DIOPT Version :9

Sequence 1:	NP_572704.1	Gene:	Gapvd1 / 32070	FlyBaseID:	FBgn0030286	Length:	1712	Species:	Drosophila melanogaster
Sequence 2:	NP_013612.1	Gene:	VPS9 / 854876	SGDID:	S000004563	Length:	451	Species:	Saccharomyces cerevisiae

Alignment Length:	269	Identity:	57/269 - (21%)
Similarity:	109/269 - (40%)	Gaps:	78/269 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1499 QEKLEQFQAEFAQLR--ASDERVELTEEFVESLL---------QELRSSADLQ------------ 1540
            :|....||....||:  .:|..|:.|:.|:.:.|         :|::..:|.:
Yeast    57 EEPFYDFQIFIKQLQTPGADPLVKYTKSFLRNFLAQRLLWTVSEEIKLISDFKTFIYDKFTLYEP 121

  Fly  1541 ----DEWQVDAARVAIERMLLEQMYEQVMFPN---------ED---ADVSRDEVLSAHI------ 1583
                |..::..|:..:|::::.::|.:...|:         :|   .|::.|:.|...|
Yeast   122 FRSLDNSKMRNAKEGMEKLIMGKLYSRCFSPSLYEILQKPLDDEHMKDLTNDDTLLEKIRHYRFI 186

  Fly  1584 -------------GKLQRFVHPAHPALCIAQEYLGEAPWTFAQQQLCHMAAYKTPREKLQCIINC 1635
                         .:|.:|||                   .|.::|..:..:|:||:|:.|::|.
Yeast   187 SPIMLDIPDTMPNARLNKFVH-------------------LASKELGKINRFKSPRDKMVCVLNA 232

  Fly  1636 ISSIMSLLRMSSGRVPAADDLLPVLIYVVIMANPPYLLSTVEYISCFLGKK-LEGEDEFYWTLFG 1699
            ...|..||:.:......||..:|||||.::.....||:|.|.||..|.... :.||:|:|.:...
Yeast   233 SKVIFGLLKHTKLEQNGADSFIPVLIYCILKGQVRYLVSNVNYIERFRSPDFIRGEEEYYLSSLQ 297

  Fly  1700 SVVKFIKTM 1708
            :.:.||..:
Yeast   298 AALNFIMNL 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gapvd1	NP_572704.1	RasGAP_RAP6	90..460	CDD:213331
Gapvd1	NP_572704.1	VPS9	1609..1709	CDD:280383	31/101 (31%)
VPS9	NP_013612.1	DUF5601	80..146	CDD:407982	8/65 (12%)
		VPS9	205..321	CDD:128469	34/121 (28%)
		CUE_VPS9_like	408..449	CDD:270552
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2319
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23101
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910