Protein Alignment Gapvd1 and ANKRD27

DIOPT Version :10

• Sequence 1: NP_572704.1
• Gene: Gapvd1 / 32070
• FlyBaseID: FBgn0030286
• Length: 1712
• Species: Drosophila melanogaster
• Sequence 2: NP_115515.2
• Gene: ANKRD27 / 84079
• HGNCID: 25310
• Length: 1050
• Species: Homo sapiens
• Alignment Length: 240
• Identity: 58/240 - (24%)
• Similarity: 107/240 - (44%)
• Gaps: 39/240 - (16%)

  Fly  1489 VRMYLAWSRQQEKLEQFQAEFAQLRASDERVELTEE-------FVESLLQELRSS---ADLQDEW 1543
            ||.:|  .|..|:.::..|.|.:.....||..|...       :.:.|.|.||.|   ...:.|.
Human   141 VREFL--GRHSERFDRNIASFHRTFRECERKSLRHHIDSANALYTKCLQQLLRDSHLKMLAKQEA 203

  Fly  1544 QVDAARVAIERMLLEQMYEQVMFPNEDADVSRDEVLSAHIGKLQRFVHPAHPALCIAQEYLGEAP 1608
            |::..:.|:|..:..::|..:.......:.|.|    |...|:.|.:..      :.|:.:|..|
Human   204 QMNLMKQAVEIYVHHEIYNLIFKYVGTMEASED----AAFNKITRSLQD------LQQKDIGVKP 258

  Fly  1609 -WTF----AQQQLCHMAAYKTPREKLQCIINCISSIMSLLRMS-SGRV----PAADDLLPVLIYV 1663
             ::|    |:::|..:....:|::||.    |:..::.|:..| |.||    ..|||||.||:|:
Human   259 EFSFNIPRAKRELAQLNKCTSPQQKLV----CLRKVVQLITQSPSQRVNLETMCADDLLSVLLYL 319

  Fly  1664 VIMANPPYLLSTVEYISCFLGKKLEGEDE--FYWTLFGSVVKFIK 1706
            ::....|..::.:.||..|....| .:||  :..|.|.:.:::|:
Human   320 LVKTEIPNWMANLSYIKNFRFSSL-AKDELGYCLTSFEAAIEYIR 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gapvd1	NP_572704.1	RasGAP_RAP6	90..460	CDD:213331
		MSCRAMM_ClfA	<546..910	CDD:468110
		YhaN	1412..>1540	CDD:443752	15/60 (25%)
		VPS9	1609..1709	CDD:460489	30/109 (28%)
ANKRD27	NP_115515.2	Sufficient for GEF activity towards RAB21. /evidence=ECO:0000269|PubMed:16525121	1..372		58/240 (24%)
		VPS9	264..363	CDD:460489	28/103 (27%)
		Sufficient for interaction with VPS29. /evidence=ECO:0000269|PubMed:24856514	396..460
		ANKRD27_zf1	429..468	CDD:439265
		Interaction with RAB32. /evidence=ECO:0000250|UniProtKB:Q3UMR0	451..730
		Interaction with RAB38. /evidence=ECO:0000250|UniProtKB:Q3UMR0, ECO:0000269|PubMed:18477474	451..600
		ANKYR	<459..616	CDD:440430
		ANK repeat	462..493	CDD:293786
		ANK repeat	495..526	CDD:293786
		ANK repeat	564..595	CDD:293786
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	625..665
		Required for interaction with VAMP7. /evidence=ECO:0000250|UniProtKB:Q3UMR0, ECO:0000269|PubMed:19745841, ECO:0000269|PubMed:23104059	658..707
		ANKYR	673..932	CDD:440430
		ANK repeat	673..741	CDD:293786
		Sufficient for interaction with VPS29. /evidence=ECO:0000269|PubMed:24856514	692..746
		ANK repeat	743..774	CDD:293786
		ANK 8	743..772
		ANK 9	776..805
		ANK repeat	780..807	CDD:293786
		ANK repeat	809..840	CDD:293786
		ANK 10	809..838
		ANK repeat	842..873	CDD:293786
		ANK 11	842..871
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	987..1050