DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gapvd1 and ankrd27

DIOPT Version :9

Sequence 1:	NP_572704.1	Gene:	Gapvd1 / 32070	FlyBaseID:	FBgn0030286	Length:	1712	Species:	Drosophila melanogaster
Sequence 2:	XP_021326420.1	Gene:	ankrd27 / 386887	ZFINID:	ZDB-GENE-121105-1	Length:	1063	Species:	Danio rerio

Alignment Length:	449	Identity:	97/449 - (21%)
Similarity:	162/449 - (36%)	Gaps:	117/449 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1295 FGTHYCDTSEDI--------LAKYRRKVSSSSEATNSDSTGNGHGV------GS--TGSVGAAAH 1343
            ||||.....|:|        |.|:|..:.|        .....||:      ||  |||..||
Zfish    34 FGTHMAVYDENILKNPFYQALEKHRPDLCS--------RVAELHGIILVPCCGSLPTGSFTAA-- 88

  Fly  1344 LHKHMNGGHIPGVVFGCVKQKLRTVLSRTDLHSGDFRQTSTTSTTMATPLQIYLQIQLAQCISLQ 1408
                    ...|.|....:|..:||         |.::.|..:.      :::|...|...||:.
Zfish    89 --------QFDGYVLQPSEQGYQTV---------DGKEVSINNN------RVHLSAGLPNPISVP 130

  Fly  1409 RLPQISHVAE-----ALRCLAQLERPQHGQLLAELQRDLERRQSYLQYLMRHRQQLLLRSEQLEQ 1468
            .|.:.:...|     ::.|:|:.....|                             :.:|:|..
Zfish   131 ILFEETFYNEKEQAYSILCIARPFESDH-----------------------------IPAEELGS 166

  Fly  1469 LEARLRGEARSSQRCLLQAL-VRMYLAWSRQQEKLEQFQAEFAQLRASDERVELTEEF------- 1525
            :.|         ..||.... ||.:|  .|..|||::|.:.|.......||..|....
Zfish   167 VPA---------PYCLKNIEDVREFL--GRHAEKLDKFVSSFCLSFKEQERKGLRHHIDSVNTLY 220

  Fly  1526 ---VESLLQELRSSADLQDEWQVDAARVAIERMLLEQMYEQVMFPNEDADVSRDEVLSAHIGKLQ 1587
               ::.||::.|.....:.|.|:...:.|:|..:...:::.:.......:.|||...:.....||
Zfish   221 TRCLQCLLRDSRLKLLARQEIQMTLLKEAVEMYIHHGIHDLLFSYVGTLEASRDAAFNKTTRSLQ 285

  Fly  1588 RFVHPAHPALCIAQEYLGEAPWTFAQQQLCHMAAYKTPREKLQCIINCISSIMSLLRMSSGRVP- 1651
            ..   ....|.:..|:....|  .|:::|..:....:|::||.||...|.:||...|.....|.
Zfish   286 DL---QQKELGVKSEFSINIP--RAKRELIQLNVCTSPQQKLLCIRKVILTIMQSTRRRDTAVSI 345

  Fly  1652 ---AADDLLPVLIYVVIMANPPYLLSTVEYISCFLGKKLEGEDEFYW--TLFGSVVKFI 1705
               .|||||.|::|::|....|..::.:.||..|..:. ..:||..:  |.|.:.|::|
Zfish   346 ESMCADDLLLVILYLLIKTEIPNWMANLSYIKHFRFRS-SSKDELSYCLTSFEAAVEYI 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gapvd1	NP_572704.1	RasGAP_RAP6	90..460	CDD:213331
Gapvd1	NP_572704.1	VPS9	1609..1709	CDD:280383	30/103 (29%)
ankrd27	XP_021326420.1	VPS9	302..403	CDD:327588	30/103 (29%)
		ANK	494..621	CDD:238125
		ANK repeat	498..529	CDD:293786
		ANK repeat	531..562	CDD:293786
		ANK repeat	564..598	CDD:293786
		ANK repeat	600..631	CDD:293786
		Ank_2	<603..>932	CDD:330894
		ANK repeat	709..736	CDD:293786
		ANK	773..898	CDD:238125
		ANK repeat	778..809	CDD:293786
		ANK repeat	811..842	CDD:293786
		ANK repeat	844..875	CDD:293786
		ANK repeat	877..908	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2319
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900