DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gapvd1 and spri

DIOPT Version :9

Sequence 1:	NP_572704.1	Gene:	Gapvd1 / 32070	FlyBaseID:	FBgn0030286	Length:	1712	Species:	Drosophila melanogaster
Sequence 2:	NP_001259418.1	Gene:	spri / 31987	FlyBaseID:	FBgn0085443	Length:	2043	Species:	Drosophila melanogaster

Alignment Length:	1687	Identity:	328/1687 - (19%)
Similarity:	519/1687 - (30%)	Gaps:	593/1687 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 QRLVESLFSARIFLTAALHAPLMGVLSEHEIWLDLDPHKLMQTFTPKEREKRFGREGDEEYQRNV 257
            :|..:.|..:|..|.::...   |:|:|.|...:.|..:      |.|.|.    ||:|..:.:.
  Fly   655 RRSRDELSQSRTSLVSSSEG---GILAEGETSSEDDEEE------PVEAED----EGEESSRDSS 706

  Fly   258 ARFHAETLGKLH----SHVQEFVKSLQQSWALFPSSLRWLLQTLSQQ---LRQSLRHEEQEIRQL 315
            .......||.:.    :|...|:..:|:|.|:.      |||...:.   :|.|.:.....:...
  Fly   707 DNSPPCDLGLMERLLVTHPMWFLPGIQRSGAVH------LLQGKEEGTFIVRGSSQPNTMAVSVR 765

  Fly   316 L---TDLVFTHFISPAIASADLLGIIDVNVSERMRHNLNQIVKLLQRLALNDEDSELVQLMELLM 377
            |   |.....|::   |.|.|     :|...|..|.....|..|:...| ...|...||||...:
  Fly   766 LPQDTGPYIEHYL---IQSHD-----NVLSLESSRFTFGSIPSLIAHYA-QCCDELPVQLMLPRV 821

  Fly   378 LGQTGEDVVAILPQQSDFERSQLAINQRELAQLV----EFFRLLTARDEYDISVEERQRLQRILG 438
            |.:                    |.|:::|:.|.    ||:..:::              ..:||
  Fly   822 LRE--------------------ANNRKKLSSLALLGQEFWSYVSS--------------PALLG 852

  Fly   439 RIPKQQVQQQQQTPKDAP--DSRESPEKSKKSNKSLMSLGKAKKKLAKGMSFSSGSSNHNPVPVS 501
            .:          ||..||  |.:....||..|......||.|        :|.|.:.:..|...:
  Fly   853 PL----------TPSVAPSKDQQLLDAKSPLSLTETSGLGTA--------TFFSDTVSKPPPTGA 899

  Fly   502 EPLTNGQANTSNGSGGLGADLEHCSSHSGSNTSLSSCGANMPTTNDPLDMSTSSDPVLVFSLYNA 566
            .||..|...:..|||.|..             ..|..|....|||..|...|:|
  Fly   900 PPLPGGGLFSPTGSGQLLG-------------FFSQAGTPSDTTNSSLSSFTTS----------- 940

  Fly   567 GAK--SKLKPLTEEEV-LKMNSIGQDGSNLLPAV--VTTAPLAPSSNNDDVSSLEAMR------- 619
            |.:  ..|.|.:.:.| |.|:.:...| :.||..  ...|||.||..:..:|:.:..:
  Fly   941 GGQHMQLLSPNSVDSVILTMSPVDNPG-HYLPGSTGAPMAPLCPSVVDQQLSTFKVAQTAPEVDQ 1004

  Fly   620 -RPQ----------------------------------------------------DDASIGNSD 631
             |||                                                    ...::||.:
  Fly  1005 VRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGSANGNFTVTTTVTFSMENGGGGGSGPTVGNGN 1069

  Fly   632 N--LEAISEAA--------HSVASSLDLEEQQERDVHENEDNLSDMVSANVSGRGTPNISGRDT- 685
            .  :|..:.||        :..||:.....::.....|.:|.||...|::...|..|......|
  Fly  1070 GKFVEVTTPAASNPFNALLNGQASTFQTFAKRLSPEGECKDTLSSQGSSSNDSRWPPPARKLLTS 1134

  Fly   686 PSSQVTDGDGAGGDLGHHHGVHARAAANPQMQKMLLSKARSDIED----KFCKFELKKFEGDENV 746
            |.:.:|...|:....|...  .:||....|..|      .|||.:    ::|...|     .:.:
  Fly  1135 PMTPLTPSGGSSSSGGKSR--KSRAGKESQHYK------ESDILESPPMQYCASAL-----SDKI 1186

  Fly   747 SIISDTWSTDVLASDSENTLDATVSERGDRDRNFSTPLIPSAVVLPGDNNFVVEALARAGRVSGV 811
            |...|.||.|  .||..:.|               |...|:...:.|..|...:.||..
  Fly  1187 SDYEDVWSHD--PSDRASLL---------------TSFRPALDTVGGVMNRRPDLLAET------ 1228

  Fly   812 HGPQLDASDQRS-----ESNWSTDVLASDSEKLAEIDTD-----------DNVS------ITTKS 854
              |......|:|     |...:.....|.|:.|.:...|           .|:|      ..|||
  Fly  1229 --PSTPTPTQQSHLTPCEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKS 1291

  Fly   855 DTTAPQAAVLDDDDEDEQTPGSSGDGEPDPDRGNGSERSQEDSAFF-DAVNSYEDANLYHGASSL 918
            .|.|       :||..:.||.:.|       :.||:.||::.|.|: :..::...|.|...|:::
  Fly  1292 MTAA-------EDDGGDTTPTAEG-------QANGASRSKQGSPFYAEPADALRQAGLTSAATAI 1342

  Fly   919 ARSSVRTSYHVLGGESSFQQQYKCSGADSSGRKTTPL------MGTSCMRRQTSAESSISNQSLN 977
            .|                 :|::.....:|.|.:.||      .|...|.:.:..|....  ||:
  Fly  1343 LR-----------------RQHRSQMLHASQRHSEPLKAGFGGSGNGAMLQPSDLEKLAG--SLD 1388

  Fly   978 LEEPPPPMGKHHHHHREHHHRDYHHHHRERERERERERSALKKKKHQQQEKEHRDLIDFSDCSED 1042
            ..:|.|.:.:...                            :.::.||..|..|:.||.......
  Fly  1389 ELKPKPKVSQQQQ----------------------------QSQQQQQPTKRARNRIDHWQLDSS 1425

  Fly  1043 KEELARNRDEEQPPGLVQQLLDMINQDEQTGAVSSSSPNVEHRRISIEQRSAIIDGRRNGILAGS 1107
            .|.:|:........|           |..|.|:....          ::.|...|.|.:|  .|.
  Fly  1426 WEFMAKQDTGSHAGG-----------DYDTAAIDWQE----------KENSLGRDSRADG--QGK 1467

  Fly  1108 MRRHQSLNYENHEIMLNSMLPKTDDDKQEMLLCVQTQQLQLEERRGSAGLRPEVDGASGIAAAGG 1172
            .|     ....|:|:.| .||  |.:..|::.|....|        :|.|:|.|.|
  Fly  1468 KR-----TLTIHQIIAN-RLP--DLNLPELVRCSTPPQ--------TAALQPHVLG--------- 1507

  Fly  1173 SGLKPPTKATGAIPKSISFDASADKDKQTYHRDGERDRERDRERERDRERDRERDRERDRERDHH 1237
                                    :||.....||.
  Fly  1508 ------------------------QDKAGVGCDGS------------------------------ 1518

  Fly  1238 GAGIFNKLRQGIFKNRRGASAKNASNSSNQSNPAASTSSVQADIRSVSFDP--SAGCDNFGTH-- 1298
                     |..|:::.|....:..|...| |......|.|:|..::..:|  |:..|.|..|
  Fly  1519 ---------QKSFQSQIGCRLSSYDNVFCQ-NSFGGIDSAQSDDGTIFSEPWDSSQWDTFLPHDD 1573

  Fly  1299 ---YCDT----------SED--ILAKYRRKVSSSSEATNSDS-TGNGHGVGSTGSVGAAAHLHKH 1347
               ..||          |||  |:.:.:.....|:.:.|.|: ..|.:|.|           |..
  Fly  1574 ATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAG-----------HHK 1627

  Fly  1348 MNGGHIPGVVFGCVKQKLRTVLSRTDLHSGDF-----RQTSTTSTTMATPLQIYLQIQLAQCISL 1407
            :|.|:..|....  :.|:.|:|....:...:.     .:.|..|:.....|:.| .:||||..|
  Fly  1628 LNNGNGNGKANN--RPKVATILRNPSMRDREVLCHPRNKMSIQSSGPGDSLRAY-TLQLAQDPS- 1688

  Fly  1408 QRLPQISHVAEALRCLAQLERPQHGQLLAELQRDLERRQSYLQ-YLMRHRQQLLLRSEQLEQLEA 1471
               ...:...|...|..:..|....|:   :.|::.:..|.:: ||::|.:...  ..:||...|
  Fly  1689 ---STFARNIENFICCTKESREAAPQV---VMRNMRQFMSGMKNYLVKHGEGKF--HAELETARA 1745

  Fly  1472 RLRGEARSSQRCLLQALVRMYLAWSRQQEKLEQFQAEFAQLRASDERV-------ELTEEFVESL 1529
            ||:.:                               ||..|.|..|.|       .|.|......
  Fly  1746 RLKSD-------------------------------EFLNLDAMLETVMHQLVVLPLREHLYGIF 1779

  Fly  1530 LQELRSSADLQDEWQVDAARVAIERMLLEQMYEQVMFPNEDADVSRDEVLSAHIGKLQRFVHPAH 1594
            :...:.|.|:|  ......|.|.||              |.||          .|.......|:.
  Fly  1780 VDHYQRSEDIQ--LLAQNVRYACER--------------EAAD----------FGIRPTVTPPSQ 1818

  Fly  1595 PALCIAQEYLGEAPWTFAQQQLCHMAAYKTPREKLQCIINCISSIMSLLRMSSGRVPAADDLLPV 1659
            .||.:....|    |...:.:|        |.:||:..:..||::........|:...|||.|||
  Fly  1819 AALRLIANLL----WRLQEAEL--------PLDKLELFLCVISTVFDATGCPRGQQLGADDFLPV 1871

  Fly  1660 LIYVVIMANPPYLLSTVEYISCFLGKKLE--------------GEDEFYWTLFGSVVKFIKT 1707
            |:|||....             |:|.::|              ||..:|.|...|.|:.:||
  Fly  1872 LVYVVAKCG-------------FVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLKT 1920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gapvd1	NP_572704.1	RasGAP_RAP6	90..460	CDD:213331	58/282 (21%)
Gapvd1	NP_572704.1	VPS9	1609..1709	CDD:280383	29/113 (26%)
spri	NP_001259418.1	SH2	716..813	CDD:301589	23/111 (21%)
		VPS9	1821..1922	CDD:280383	31/125 (25%)
		UBQ	1946..2026	CDD:294102
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454066
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23101
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940