DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gapvd1 and Ankrd27

DIOPT Version :9

Sequence 1:	NP_572704.1	Gene:	Gapvd1 / 32070	FlyBaseID:	FBgn0030286	Length:	1712	Species:	Drosophila melanogaster
Sequence 2:	NP_663608.3	Gene:	Ankrd27 / 245886	MGIID:	2444103	Length:	1048	Species:	Mus musculus

Alignment Length:	239	Identity:	57/239 - (23%)
Similarity:	107/239 - (44%)	Gaps:	37/239 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1489 VRMYLAWSRQQEKLEQFQAEFAQLRASDERVELTE--EFVESL----LQELRSSADL----QDEW 1543
            ||.:|  .|..||.::..|.|.:.....||..|..  :.|.:|    ||:|...:.|    :.|.
Mouse   141 VREFL--GRHSEKFDKNIASFHRTFRECERKSLRHHIDSVNALYTKCLQQLLRDSHLKVLAKQEA 203

  Fly  1544 QVDAARVAIERMLLEQMYEQVMFPNEDADVSRDEVLSAHIGKLQRFVHPAHPALCIAQEYLGEAP 1608
            |::..:.|:|..:...:|:.:.......:.|.|    |...|:.|.:..      :.|:.:|..|
Mouse   204 QMNLMKQAVEMYVHHDIYDLIFKYVGTMEASED----AAFNKITRSLQD------LQQKDIGVKP 258

  Fly  1609 -WTF----AQQQLCHMAAYKTPREKLQCIINCISSIMSLLRMS-SGRV----PAADDLLPVLIYV 1663
             ::|    |:::|..:....:|::||.    |:..::.|:..| |.||    ..|||||.||:|:
Mouse   259 EFSFNIPRAKRELGQLNKCTSPQQKLL----CLRKVVQLMTQSPSQRVNLETMCADDLLSVLLYL 319

  Fly  1664 VIMANPPYLLSTVEYISCF-LGKKLEGEDEFYWTLFGSVVKFIK 1706
            ::....|..::.:.||..| .....:.|..:..|...:.:::|:
Mouse   320 LVKTEIPNWMANLSYIKNFRFSSSAKDELGYCLTSVEAAIEYIR 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gapvd1	NP_572704.1	RasGAP_RAP6	90..460	CDD:213331
Gapvd1	NP_572704.1	VPS9	1609..1709	CDD:280383	27/108 (25%)
Ankrd27	NP_663608.3	Sufficient for GEF activity towards RAB21. /evidence=ECO:0000250\|UniProtKB:Q96NW4	1..372		57/239 (24%)
		VPS9	264..363	CDD:302927	25/102 (25%)
		Sufficient for interaction with VPS29. /evidence=ECO:0000250\|UniProtKB:Q96NW4	396..460
		Interaction with RAB32. /evidence=ECO:0000269\|PubMed:19403694	451..729
		Interaction with RAB38. /evidence=ECO:0000269\|PubMed:19403694	451..600
		ANK	458..585	CDD:238125
		ANK repeat	462..493	CDD:293786
		Ank_2	467..559	CDD:289560
		ANK repeat	495..526	CDD:293786
		ANK repeat	528..556	CDD:293786
		ANK repeat	564..595	CDD:293786
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..650
		Required for interaction with VAMP7. /evidence=ECO:0000250\|UniProtKB:Q96NW4, ECO:0000269\|PubMed:19745841	658..707
		Ank_2	673..806	CDD:289560
		Sufficient for interaction with VPS29. /evidence=ECO:0000250\|UniProtKB:Q96NW4	692..745
		ANK	737..862	CDD:238125
		ANK repeat	742..773	CDD:293786
		ANK 8	742..771
		ANK 9	775..804
		ANK repeat	779..806	CDD:293786
		Ank_2	780..872	CDD:289560
		ANK repeat	808..839	CDD:293786
		ANK 10	808..837
		ANK repeat	841..872	CDD:293786
		ANK 11	841..870
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	949..1019
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2319
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810