DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gapvd1 and rme-6

DIOPT Version :9

Sequence 1:	NP_572704.1	Gene:	Gapvd1 / 32070	FlyBaseID:	FBgn0030286	Length:	1712	Species:	Drosophila melanogaster
Sequence 2:	NP_508208.2	Gene:	rme-6 / 180463	WormBaseID:	WBGene00004377	Length:	1093	Species:	Caenorhabditis elegans

Alignment Length:	1740	Identity:	325/1740 - (18%)
Similarity:	536/1740 - (30%)	Gaps:	705/1740 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EIMDLARTLRQEQLFI----------QQEQA--AFAQLTGAFES----NAGTITKLAFVCAQQRQ 59
            |..:||..:|.::|..          |||.:  ....||.|:.|    |.|            ||
Worm    16 EFYELATKIRNQKLLTDAELHSLNRHQQEVSDNEIKLLTEAWRSSYWNNVG------------RQ 68

  Fly    60 ILNELLLARTDQDPLLFCRRASAYDSAQFVDAKQLLPYEHALAYEDLFNYLYNTPYLLALSLATA 124
            :.|:.|      :|.:.||........:.:.|.:.:.: |....:.|...|||.|..:|..|.:.
Worm    69 LKNQAL------EPTIACRLLKEISETEALPAYKHVGH-HFSTLDQLLTILYNEPQSVAELLNSI 126

  Fly   125 DRLSLLSASQLGQIINTIATGLYGNAINTKDVELLLKLLRELIEIQLLTS-EQPRRLLRTNSSSF 188
            ||..:.|.....|::..:   :|..|:..:|...:.:::..|:::||..| .:.|.:||..:|..
Worm   127 DRNDITSNDSTIQVLFHL---VYSCALYPEDELKIAQVVCNLLKLQLYRSGSEMRTILRKETSIS 188

  Fly   189 ARLYQRLVESLFSARIFLTAALHAPLMGVLSEHEIWLDLDPHKLMQTFTPKEREKRFGREGDEEY 253
            .|.|:..||.:....::||.||...::.|:.....|||:|         .|:...||.|:..:..
Worm   189 TRFYKHFVELIHPTMVYLTKALRKGVLDVIQLGSFWLDID---------AKQSTARFLRDNKQNE 244

  Fly   254 QRNVARFHAETLGKLHSHVQEFVKSLQQSWALFPSSLRWLLQTLSQQLRQSLRHEEQ-EIRQLLT 317
            .| :..:.|..:.||...|..|::::.::..:.|.:|.|:::.:...|.:.:..... |:.....
Worm   245 DR-LPEYRALVVSKLVDFVDTFLENISKALPMLPPNLNWIIRDIFCSLYEVVDDVSAIELSHACK 308

  Fly   318 DLVFTHFISPAIASADLLGII--DVNVSERMRHNLNQIVKLLQRLALNDEDSELVQLMELLMLGQ 380
            |::.::.|.|||.|....|::  ||.|...:.|||.||..::|.::|.:.:|...:..|.|
Worm   309 DMIVSNLICPAIISPQKFGVVDNDVRVGTIVNHNLVQIAMIIQMISLREFESPPEEYKEFL---- 369

  Fly   381 TGEDVVAILPQQSDFERSQLAINQRELAQLVEFFRLLTARDEYDISVEERQRLQRILGRIPKQQV 445
                        |....:.| |::...|.|||
Worm   370 ------------SQCRNTHL-ISEMMDALLVE--------------------------------- 388

  Fly   446 QQQQQTPKDAPDSRESPEKSKKSNKSLMSLGKAKKKLAKGMSFSSGSSNHNPVPVSEPLTNGQAN 510
                   |.|||...:         ||::.|.|:..:|...||.
Worm   389 -------KLAPDVEIT---------SLIANGTAESDMATKSSFV--------------------- 416

  Fly   511 TSNGSGGLGADLEHCSSHSGSNTSLSSCGANMPTTNDPLDMSTSSDPVLVFSLYNAGAKSKLKPL 575
                  |..||:          ..|.....|.|:|:|                      :||
Worm   417 ------GTVADV----------NVLIKIIRNAPSTSD----------------------AKL--- 440

  Fly   576 TEEEVLKMNSIGQDGSNLLPAVVTTAPLAPSSNNDDVSSLEAMRRPQDDASIGNSDNLEAISEAA 640
              ..:|.:       .:.|||.:::.                       ....:.|||    ||:
Worm   441 --SRILSV-------CDKLPATISST-----------------------TQKSHFDNL----EAS 469

  Fly   641 HSVASSLDLEEQQERDVHENEDNLSDMVSANVSGRGTPNISGRDTPSSQVTDGDGAGGDLGHHHG 705
            ..:::..::..:.:.......|:.:|:                              .:||...|
Worm   470 PKISTLRNIHRKVQHSFKRTGDSFNDI------------------------------NELGAKQG 504

  Fly   706 VHARAAANPQMQKMLLSKARSDIEDKFCKFELKKFEGDENVSIISDTWSTDVLASDSENTLDATV 770
                                          |...| |.||..:....:|
Worm   505 ------------------------------EALAF-GKENFDLFYLEYS---------------- 522

  Fly   771 SERGDRDRNFSTPLIPSAVVLPGDNNFVVEALARAGRVSGVHGPQLDASDQRSESNWSTDVLASD 835
                  .:|:                   :.:|.|.|:      :..|.::|.         .:|
Worm   523 ------PKNY-------------------KDVAEADRL------KKKAEERRQ---------LAD 547

  Fly   836 SEKLAEIDTDDNVSITTKSDTTAPQAAVLDDDDEDEQTPGSSGDGEPDPDRGNGSERSQEDSAFF 900
            .|||.|             .|.||:...::::..|    .|||..|.:
Worm   548 LEKLLE-------------PTPAPKETPVENNLID----FSSGSAETN----------------- 578

  Fly   901 DAVNSYEDANLYHGASSLARSSVRTSYHVLGGESSFQQQYKCSGADSSGRKTTPLMGTSCMRRQT 965
                                     |.|:               :||:.....||..|.
Worm   579 -------------------------SEHL---------------SDSTSVSPEPLTSTE------ 597

  Fly   966 SAESSISNQSLNLEEPPPPMGKHHHHHREHHHRDYHHHHRERERERERERSALKKKKHQQQEKEH 1030
              |..|.:|.:..|                                  :|..|.|.|
Worm   598 --ELQIGDQGVGGE----------------------------------QRGKLAKLK-------- 618

  Fly  1031 RDLIDFSDCSEDKEELARNRDEEQPPGLVQQLLDMINQDEQTGAVSSSSPNVEHRRISIEQRSAI 1095
                                                                           ::
Worm   619 ---------------------------------------------------------------SL 620

  Fly  1096 IDGRRNGILAGSMRRHQSLNYENHEIMLNSMLPKTDDDKQEMLLCVQTQQLQLEERRGSAGLRPE 1160
            .|..:.||...:                      |..|.:|.|            ||
Worm   621 SDRMKKGITQSN----------------------TLSDIREHL------------RR-------- 643

  Fly  1161 VDGASGIAAAGGSGLKPPTKATGAIPKSISFDASADKDKQTYHRDGERDRERDRERERDRERDRE 1225
                      .||.:|||   ...||.|
Worm   644 ----------SGSFVKPP---PSGIPTS------------------------------------- 658

  Fly  1226 RDRERDRERDHHGAGIFNKLRQGIFKNRRGASAKNASNSSNQSNPAASTSSVQADIRSVSFDPSA 1290
                                                  ||.|:.|..:|.
Worm   659 --------------------------------------SSEQNLPDVATG--------------- 670

  Fly  1291 GCDNFGTHYCDTSEDILAKYRRKVSSSSEATNSDSTGN-GHGVGSTGSVGAAAHLHKHMNGGHIP 1354
                       ..:||||||   .|.||......:.|| ..|..|..|......|..:.:..::.
Worm   671 -----------PRDDILAKY---ASISSIKEQKPALGNLIDGTASASSTPRKEPLEPYYSSENLV 721

  Fly  1355 GV-VFGCVKQKLRTVLSRTDL--HSGDFRQTSTTSTTMATPLQIYLQIQLAQCISLQRLPQISHV 1416
            |. .|....:|:.|||.....  ..|...:|..........|..:|...|.:....:.....:.:
Worm   722 GCRAFQDTLRKMITVLGNISYLPRIGYRNETKQNEWDKKVLLGRFLDGVLVETEHRREYGLAAQL 786

  Fly  1417 AEALRCLAQLERPQHGQLLAELQRDLERRQSYLQYLMRHRQQLLLRSEQLEQLEARLRGEARSSQ 1481
            .|..||:...|......|:..|:.:...:...:..:...|..|:.:|..:..||.|:....|.::
Worm   787 REVKRCIELFEHAGVEILMDHLKLNEAEQDKIVNGMREERASLMRKSNDISSLEQRVLLNRRLTE 851

  Fly  1482 RCLLQALVRMYL--------AWSRQQE--KLEQFQAEFAQLRASDERVELTEEFVESLLQELRSS 1536
            :.|:..|:|.:|        ...:.||  .:.:|..||..|||.|||.    ||:::||..||..
Worm   852 QILVDFLMRTFLETGFNNKHTVGKTQEVTAVLKFYDEFKYLRAQDERA----EFLKNLLTFLRDR 912

  Fly  1537 ADLQDEW------QVDAARVAIERMLLEQMYEQVMFPNEDADVSRDEVLSAHIGKLQRFVHPAHP 1595
            .....:|      .:..|...|||.::..:|:...:||.|||..||::|...|.|:...|.|.:.
Worm   913 LMQNVDWNFATDTMMSRAMTTIERYVIFAVYDNAFYPNRDADHHRDKLLRGTIAKVSDVVTPVND 977

  Fly  1596 ALCIAQEYLGEAPWTFAQQQLCHMAAYKTPREKLQCIINCISSIMSLLRMSS-GRVPAADDLLPV 1659
            .|.|.:...|||||..||.:|..:..|.|.::||.|::.|...|.:|:.:|| ..|.:||||.||
Worm   978 FLKIPEHLHGEAPWPSAQAELSMLDIYVTAQDKLNCVVRCCDVINNLVALSSKNAVASADDLTPV 1042

  Fly  1660 LIYVVIMANPPYLLSTVEYISCFLGKKLE-GEDEFYWTLFGSVVKFIKTM 1708
            |::|:|.|||..|||.|:::..|.|.::| |.|.:||..|.|.|::|||:
Worm  1043 LVFVIIKANPRALLSNVQFVETFAGDRIESGRDAYYWVNFKSAVEYIKTI 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gapvd1	NP_572704.1	RasGAP_RAP6	90..460	CDD:213331	83/373 (22%)
Gapvd1	NP_572704.1	VPS9	1609..1709	CDD:280383	44/102 (43%)
rme-6	NP_508208.2	RasGAP_RAP6	93..437	CDD:213331	97/460 (21%)
rme-6	NP_508208.2	VPS9	990..1093	CDD:128469	45/103 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160569
Domainoid	1	1.000	90	1.000	Domainoid score	I4940
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I1845
Isobase	1	0.950	-	0	Normalized mean entropy	S6125
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D196591at33208
OrthoFinder	1	1.000	-	-		FOG0008423
OrthoInspector	1	1.000	-	-		oto19740
orthoMCL	1	0.900	-	-		OOG6_105565
Panther	1	1.100	-	-	LDO	PTHR23101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2763
SonicParanoid	1	1.000	-	-		X6414
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880