Protein Alignment HOXA11 and HGTX

DIOPT Version :10

• Sequence 1: NP_005514.1
• Gene: HOXA11 / 3207
• HGNCID: 5101
• Length: 313
• Species: Homo sapiens
• Sequence 2: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 355
• Identity: 87/355 - (24%)
• Similarity: 129/355 - (36%)
• Gaps: 80/355 - (22%)

Human     8 PCSSNMY---LPSCTY-YVSGPDFSSLPSF-LPQTPSSR--PMTYSYSSNLPQVQPVREVTFREY 65
            |.||.::   .||..| :.|.|...|..|: |.|..|..  |...|.|:: |..|...:.:....
  Fly   185 PASSRLHSDSSPSPRYEHNSSPGVDSAKSYALSQRSSGAEDPCQTSESAS-PPPQGQNDYSPENL 248

Human    66 AIEPATKWHPRG-------NLAH-----CYSAEELVHRD------CLQAPSAA-----------G 101
            :.:.|...|..|       |..|     |::...  |.|      .|..|.||           |
  Fly   249 SSQRAKFQHHHGVNPLALHNANHAGNPGCHNNNN--HMDHKLPLSFLGPPLAALHSMTTEMKGQG 311

Human   102 VPGDVLAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQFFETAYGTPENLASSDYPGDKSAE 166
            |.|...:.:..:..|.|    :|:..|..|..|    :......|...|....|.:.:..|....
  Fly   312 VGGSSASANGLSYSHSP----NSHLISDRGSGG----SSSSSSTTTTNTNSQGAPNPHGIDTILS 368

Human   167 KGPPAATATSAA-----------AAAAATGAPATSSSDSGGGGGCRETAA--------------- 205
            |.||..:|..:|           |||||..|...|.|.    |...:|.|
  Fly   369 KPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQYLSQSQ----GAPLKTHAGHIVDRTHLYWPGLQ 429

Human   206 --AAEEKERRRRPESSSSPESSSGHTEDKAGGSSGQRTRKKRCPYTKYQIRELEREFFFSVYINK 268
              .|.....|.|..::.|...|..|....:....|:: :..|..::..||..||:.|..:.|:..
  Fly   430 GLVANPIAWRERLSNTMSANLSQSHQHHPSNDKDGKK-KHTRPTFSGQQIFALEKTFEQTKYLAG 493

Human   269 EKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 298
            .:|.:|:..|.:::.|||:||||||.|.:|
  Fly   494 PERAKLAYALGMSESQVKVWFQNRRTKWRK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXA11	NP_005514.1	DUF3528	25..153	CDD:432284	34/159 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..246		25/119 (21%)
		Homeodomain	242..298	CDD:459649	20/55 (36%)
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	48/213 (23%)
		Homeodomain	465..523	CDD:459649	20/58 (34%)