Protein Alignment HOXA11 and Dr

DIOPT Version :10

• Sequence 1: NP_005514.1
• Gene: HOXA11 / 3207
• HGNCID: 5101
• Length: 313
• Species: Homo sapiens
• Sequence 2: NP_477324.1
• Gene: Dr / 45285
• FlyBaseID: FBgn0000492
• Length: 515
• Species: Drosophila melanogaster
• Alignment Length: 351
• Identity: 86/351 - (24%)
• Similarity: 122/351 - (34%)
• Gaps: 101/351 - (28%)

Human    35 PQ--TPSSRPMTYSYSSNLPQVQPVREVTFREYAIEPATKWHPRG--------NLAHCYSAEELV 89
            ||  |.|:.....|.:|:.|...|....     |..||..:||..        ..||..:|....
  Fly   156 PQNLTSSAATSPISQASSTPPPPPASAA-----AQVPANTFHPAAVAHHAHLLQAAHAAAAAHAQ 215

Human    90 HRDCL--------QAPSAAGVP-------------GDVLAKSSANVYHHPTPAVSSNFYSTVGRN 133
            |:...        ||.:.|..|             |..|. |..||  ..|||.:.. :|.:|.:
  Fly   216 HQAMAAQLRQQQQQADARANSPPASTSSTPSSTPLGSALG-SQGNV--ASTPAKNER-HSPLGSH 276

Human   134 GVLPQAFDQFF------------------------ETAYGTPENLASSDYPGDKSAEK--GPP-- 170
            ......:|:..                        ::...||:.|..|    .||.|.  |||
  Fly   277 TDSELEYDEEMLQDHEADHDEEEDSIVDIEDMNADDSPRSTPDGLDGS----GKSLESPHGPPPG 337

Human   171 ---AATATSAAAAA-----------AATGAPATSSSDSGGGGGCRETAAAAEEKERRRRPESSSS 221
               .:|..|.||.|           :|..|.|.:.:..|||.....|        |:..|.....
  Fly   338 SHMQSTILSPAALASGHVPIRPTPFSALAAAAVAWTGMGGGVPWPGT--------RQMPPFGPPG 394

Human   222 PESSSGHTED-------KAGGSSGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLN 279
            ....:|...|       |......:..||.|.|:|..|:..||::|....|::..:|.:.|..|.
  Fly   395 MFPGAGFGGDANEPPRIKCNLRKHKPNRKPRTPFTTQQLLSLEKKFREKQYLSIAERAEFSSSLR 459

Human   280 LTDRQVKIWFQNRRMKEKKINRDRLQ 305
            ||:.||||||||||.|.|::....::
  Fly   460 LTETQVKIWFQNRRAKAKRLQEAEIE 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXA11	NP_005514.1	DUF3528	25..153	CDD:432284	34/172 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..246		27/116 (23%)
		Homeodomain	242..298	CDD:459649	26/55 (47%)
Dr	NP_477324.1	Homeodomain	422..478	CDD:459649	26/55 (47%)