Protein Alignment HOXA11 and tin

DIOPT Version :10

• Sequence 1: NP_005514.1
• Gene: HOXA11 / 3207
• HGNCID: 5101
• Length: 313
• Species: Homo sapiens
• Sequence 2: NP_524433.1
• Gene: tin / 42536
• FlyBaseID: FBgn0004110
• Length: 416
• Species: Drosophila melanogaster
• Alignment Length: 287
• Identity: 72/287 - (25%)
• Similarity: 112/287 - (39%)
• Gaps: 56/287 - (19%)

Human    28 SSLPSFLPQTPSSRPMTYSYSSNLPQVQPVREVTFREYAIEPATKW-----HPRGNLAHCYSAEE 87
            |||...||..|..     .|..            :::|.: ||..:     ||..:..|..||..
  Fly   112 SSLSPLLPPPPHQ-----LYGG------------YQDYGM-PAHMFQHHHGHPHQSFQHSASAYN 158

Human    88 LVHRDCLQAPSAAGVPGDVLAKSSANVYHHPTPAVSSNFYSTVGR--NGVLPQAF---DQFFETA 147
            :         ||:    ...|.:||..|.  |||..:..|:..|.  .|..|.|.   .::..|.
  Fly   159 M---------SAS----QFYAGASATAYQ--TPATYNYNYAGSGEVYGGATPSAVGIKSEYIPTP 208

Human   148 YGTPENLASSDYPGDKSAEKGPPAATATSAAAAAAATGAPATSS------SDSGGGGGCRETAAA 206
            |.||......:...:..:.:.|......:..:......|..:||      ||.|..........:
  Fly   209 YVTPSPTLDLNSSAEVDSLQAPTQKLCVNPLSQRLMETASNSSSLRSIYGSDEGAKKKDNSQVTS 273

Human   207 AEEKERRRRPESSSSPESSSGHTEDKAGGSSGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKR 271
            :..:.|:.....:|:|.|:||.|:.:       ..||.|..:::.|:.|||..|....|:...:|
  Fly   274 SRSELRKNSISGNSNPGSNSGSTKPR-------MKRKPRVLFSQAQVLELECRFRLKKYLTGAER 331

Human   272 LQLSRMLNLTDRQVKIWFQNRRMKEKK 298
            ..:::.|||:..||||||||||.|.|:
  Fly   332 EIIAQKLNLSATQVKIWFQNRRYKSKR 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXA11	NP_005514.1	DUF3528	25..153	CDD:432284	33/134 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..246		16/97 (16%)
		Homeodomain	242..298	CDD:459649	24/55 (44%)
tin	NP_524433.1	Homeodomain	302..358	CDD:459649	24/55 (44%)