Protein Alignment HOXA11 and Dbx

DIOPT Version :10

• Sequence 1: NP_005514.1
• Gene: HOXA11 / 3207
• HGNCID: 5101
• Length: 313
• Species: Homo sapiens
• Sequence 2: NP_647677.2
• Gene: Dbx / 38254
• FlyBaseID: FBgn0261723
• Length: 741
• Species: Drosophila melanogaster
• Alignment Length: 443
• Identity: 96/443 - (21%)
• Similarity: 143/443 - (32%)
• Gaps: 165/443 - (37%)

Human     1 MDFDER---------GPCSSNMYLPSCTYYVSGPDFSSLP----SFLPQTPSSRPMTYSYSSNLP 52
            ||.||.         .|.|  :.||...     |..:|:|    :.|..|.|...:.:|.|:.|.
  Fly   105 MDLDEELEEELADVDEPVS--IKLPKVE-----PKETSMPTVGNTILKDTNSKPILKFSVSAILG 162

Human    53 QVQPVRE-VTFREYAIEPATKW-HPRGNLAHCYSAEELVHRDCLQAPS-----AAGVPGDVLAKS 110
            .   .|| |..|...::|...| :.:.|....:|.:...|....|..|     ...|||...:..
  Fly   163 D---TREGVRVRNEFMQPQHIWPYLQQNFMQQHSHQYQQHHQQQQPHSHPQHQPLAVPGHQHSHP 224

Human   111 SANVYHHPTP-AVSSNFYSTVGRNGVLP--QAFDQFFETAYGTPENLASSDYPGDKSAEKGPPAA 172
            .::.:||..| |..::|.........||  |...|         :......:||:...   |..|
  Fly   225 HSHHHHHHHPGAGHAHFPHPAFLTHQLPPHQHHQQ---------QQHVQQQHPGNSCQ---PQTA 277

Human   173 TATSAAAAAAATGAPATSSSDS----------GGGGGCRETAAAAEEKE-RRRRPESSSSPESSS 226
            :::|         :|.::.|||          |.|.|...:...|...| ....|:..||  :|.
  Fly   278 SSSS---------SPGSTISDSDNNHGASTANGNGSGTGNSGQDARPHELANSNPDEDSS--ASR 331

Human   227 GHTEDK--------AGGSSG--------------------------------------------- 238
            ..|:||        |||:.|
  Fly   332 RLTQDKQQQQQLLGAGGTGGGGGGGHGHGHPTPPPPPPPPVIAKPMPSRPTPFLPHTLNHPHLHS 396

Human   239 -----------------------------------QRTRKKRCPYTKYQIRELEREFFFSVYINK 268
                                               :|...:|..::..|.:.||:.|....||:|
  Fly   397 LLAHCRNPYMSVGAQVFPLPPGQGFPWAHSTRGKPRRGMMRRAVFSDSQRKGLEKRFQQQKYISK 461

Human   269 EKRLQLSRMLNLTDRQVKIWFQNRRM-----KEKKI-----NRDRLQYYSANP 311
            ..|.:|:..|.|.|.|||||||||||     ||:::     :||:......||
  Fly   462 PDRKKLAERLGLKDSQVKIWFQNRRMKWRNSKERELLASGGSRDQTLPNKNNP 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXA11	NP_005514.1	DUF3528	25..153	CDD:432284	32/141 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..246		26/190 (14%)
		Homeodomain	242..298	CDD:459649	26/60 (43%)
Dbx	NP_647677.2	Homeodomain	437..491	CDD:459649	24/53 (45%)