Protein Alignment HOXA11 and en

DIOPT Version :10

• Sequence 1: NP_005514.1
• Gene: HOXA11 / 3207
• HGNCID: 5101
• Length: 313
• Species: Homo sapiens
• Sequence 2: NP_523700.2
• Gene: en / 36240
• FlyBaseID: FBgn0000577
• Length: 552
• Species: Drosophila melanogaster
• Alignment Length: 300
• Identity: 79/300 - (26%)
• Similarity: 114/300 - (38%)
• Gaps: 88/300 - (29%)

Human    76 RGNLAHCY--SAEELVHRDCLQAPSAAGVPGDVLAKSSAN-VYHHPTPAVSSNFYSTVGRNGVLP 137
            |.|..:|:  :|...:|.:.:|:.         |.:|:|| |...|..:..|:........|.|.
  Fly   245 RANFLNCFNPAAYPRIHEEIVQSR---------LRRSAANAVIPPPMSSKMSDANPEKSALGSLC 300

Human   138 QAFDQFFETAYGTPENLASSDYPGDKSAEK--GPPAATATSAAAAAAATGAPATSSSDSGGGGGC 200
            :|..|.     |.|.....:..|...||..  .||.|   |.|:..::|.:.|||||.|  ..||
  Fly   301 KAVSQI-----GQPAAPTMTQPPLSSSASSLASPPPA---SNASTISSTSSVATSSSSS--SSGC 355

Human   201 RETAAAAEEKERRR---------------RP-------------ESSSSPESSSGHTEDKAG--- 234
            ...|::.......|               :|             |||....|.:|.|..:.|
  Fly   356 SSAASSLNSSPSSRLGASGSGVNASSPQPQPIPPPSAVSRDSGMESSDDTRSETGSTTTEGGKNE 420

Human   235 --------------GSSGQRTRKKRCP-------------YTKYQIRELEREFFFSVYINKEKRL 272
                          .|||.|.|:.:.|             ::..|:..|:|||..:.|:.:.:|.
  Fly   421 MWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQ 485

Human   273 QLSRMLNLTDRQVKIWFQNRRMKEKKINRDRLQYYSANPL 312
            |||..|.|.:.|:||||||:|.|.||...      |.|||
  Fly   486 QLSSELGLNEAQIKIWFQNKRAKIKKSTG------SKNPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXA11	NP_005514.1	DUF3528	25..153	CDD:432284	19/79 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..246		32/138 (23%)
		Homeodomain	242..298	CDD:459649	23/68 (34%)
en	NP_523700.2	Homeodomain	455..511	CDD:459649	21/55 (38%)
		Engrail_1_C_sig	512..542	CDD:431338	3/13 (23%)