Protein Alignment HOXA11 and inv

DIOPT Version :10

• Sequence 1: NP_005514.1
• Gene: HOXA11 / 3207
• HGNCID: 5101
• Length: 313
• Species: Homo sapiens
• Sequence 2: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 263
• Identity: 71/263 - (26%)
• Similarity: 100/263 - (38%)
• Gaps: 91/263 - (34%)

Human    90 HRDCLQAPSAAGVPGDVLAKSSANVYHHPTPAVSS-NFYSTVGR-----NGVLPQAFDQFFETAY 148
            :|..|:||..:|.|.: ||:|:|       .|.|| :|.|::..     |.....|.........
  Fly   325 NRSPLKAPKKSGKPLN-LAQSNA-------AANSSLSFSSSLANICSNSNDSNSTATSSSTTNTS 381

Human   149 GTPENLASSDYPGDKSAEKGPPAATATSAAAAAAATG---------------------------- 185
            |.|.:|.           |.||.|....|..|:..:|
  Fly   382 GAPVDLV-----------KSPPPAAGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRSP 435

Human   186 ------APATSSSDSGGGGGCRETAAAAEEKERRRRPESSSSPESSSGHTEDKAGGSSGQRTRKK 244
                  .||||||.:|||||..|...||:                ..|..|||          :.
  Fly   436 RARKPKKPATSSSAAGGGGGGVEKGEAAD----------------GGGVPEDK----------RP 474

Human   245 RCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKINRDRLQYYSA 309
            |..::..|:..|:.||..:.|:.:::|.|||..|.|.:.|:||||||:|.|.||.:..:
  Fly   475 RTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRAKLKKSSGTK------ 533

Human   310 NPL 312
            |||
  Fly   534 NPL 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXA11	NP_005514.1	DUF3528	25..153	CDD:432284	19/68 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..246		26/125 (21%)
		Homeodomain	242..298	CDD:459649	21/55 (38%)
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	22/65 (34%)
		Engrail_1_C_sig	529..554	CDD:431338	3/14 (21%)