Protein Alignment HOXA11 and cad

DIOPT Version :10

• Sequence 1: NP_005514.1
• Gene: HOXA11 / 3207
• HGNCID: 5101
• Length: 313
• Species: Homo sapiens
• Sequence 2: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Alignment Length: 367
• Identity: 83/367 - (22%)
• Similarity: 118/367 - (32%)
• Gaps: 151/367 - (41%)

Human    65 YAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAGVP-----------------GDV------ 106
            |...|.|:.|...|||:.               ||||.|                 |||
  Fly     6 YNTLPYTQKHSAANLAYA---------------SAAGQPWNWTPNYHHTPPNHQFLGDVDSSHAA 55

Human   107 -------------------LAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQFFETAYGTPE 152
                               .|.:||..:|.|..:.:.||...|      |.:..|..:..:....
  Fly    56 HHAAAAHQMYYNSHHMFHSAAAASAGEWHSPASSTADNFVQNV------PTSAHQLMQQHHHHHA 114

Human   153 NLASSDYPGDKSAEKGPPAA-----TATSAAAAAAATGAPATSSSDSGGGGG------------- 199
            :.:||......|:..|.|.|     |.:|.....|..|.....::|.|.|..
  Fly   115 HASSSSASSGSSSSGGAPGAPQLNETNSSIGVGGAGGGGGVGGATDGGPGSAPPNHQQHIAEGLP 179

Human   200 CRETAAAAEEKERRRRPESSSSPE----------------------------------------- 223
            ......:..|......|.|:|||.
  Fly   180 SPPITVSGSEISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNR 244

Human   224 -------------------------SSSGHTEDKAG--GSSGQ-RTRKK-RCPYTKYQIRELERE 259
                                     |||.:.||.:.  .:||: ||:.| |..||.:|..|||:|
  Fly   245 TSPSKPPYFDWMKKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKE 309

Human   260 FFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKINR 301
            :..|.||...::.:|::.|:|::|||||||||||.||:|.|:
  Fly   310 YCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNK 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXA11	NP_005514.1	DUF3528	25..153	CDD:432284	25/129 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..246		29/179 (16%)
		Homeodomain	242..298	CDD:459649	28/56 (50%)
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	28/54 (52%)