Protein Alignment Ir10a and gria4a

DIOPT Version :10

• Sequence 1: NP_001096949.1
• Gene: Ir10a / 32067
• FlyBaseID: FBgn0083979
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_999971.1
• Gene: gria4a / 407735
• ZFINID: ZDB-GENE-020125-7
• Length: 898
• Species: Danio rerio
• Alignment Length: 567
• Identity: 107/567 - (18%)
• Similarity: 206/567 - (36%)
• Gaps: 160/567 - (28%)

  Fly   118 DQDKDLSADEQLRLEGSCRQLWTQHKVYNRFFLTRDGVWIYDPFKRRDSAFGRLVRYYGSETLDK 182
            |.::.|   :|:|::|....:...|  |.|..     .:..|.|:.:.:. .|.:.|:..  |||
Zfish   339 DMERTL---KQVRIQGLTGNIQFDH--YGRRV-----NYTMDVFELKSNG-PRKIGYWND--LDK 390

  Fly   183 LLFRDMAGYPLRIQMFRSVYTRPEFDKETGLLTRVTGVDFL------------------------ 223
            |:.         :|...|:......:..|.::|.:....::
Zfish   391 LVL---------VQNELSMGNDSAMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQFEGYCVDLAS 446

  Fly   224 -VAQMLRERLNFTMLLQQPEKKYFGERSANGSYNGAIGSIIKDGLDICLTGFFVKDYLV-QQYMD 286
             ||:.:..:...:::|   :.||.........:||.:|.::....:|.:....:.  || ::.:|
Zfish   447 EVAKHIGIKYKISIVL---DGKYGARDPETKIWNGMVGELVYGKAEIAVAPLAIT--LVREEVID 506

  Fly   287 FTVAVYDDELCIYVPKASRIPQSILP-IFA----VGYDIWLGFVLTAFACALIWLTLRVINLKLR 346
            |:.......:.|.:.|    ||...| :|:    :.|:||:..|......:::          |.
Zfish   507 FSKPFMSLGISIMIKK----PQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV----------LF 557

  Fly   347 IVSLGNQH-----------------IVGQALGIMVDTWV---VWVRLNLSHLPASYAERMFIGTL 391
            :||..:.:                 ......||....|.   .:::......|.|.:.|:..|..
Zfish   558 LVSRFSPYEWHTEEPEEGSDGPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVW 622

  Fly   392 CLVSVIFGAIFESSLA---TV--YIHPL-YYKDINTMQE-----LDESGLK--------VVYK-- 435
            ...::|..:.:.::||   ||  .:.|: ..:|:....|     ||....|        .||:
Zfish   623 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKM 687

  Fly   436 --YSSMADDLFFSETSPLFASLNKKLSWNRDLRADVIDEVARFRNKAGVSRYTSLILES--SHFT 496
              |...|:...|::|:                    .:.|||.|...|  :| :.:|||  :.:|
Zfish   688 WSYMKSAEPTVFTKTT--------------------AEGVARVRKSKG--KY-AFLLESTMNEYT 729

  Fly   497 LLRKIWVVPEC----------PKYYTISYVMPRDSPWEDAVNALLLRFLNAGLIVKWIQDEKSWV 551
            ..||     .|          .|.|.::  .|:.|.....||..:|:...||::.|  ...|.|.
Zfish   730 EQRK-----PCDTMKVGGNLDSKGYGVA--TPKGSQLGTPVNLAVLKLSEAGVLDK--LKNKWWY 785

  Fly   552 DIKMRSNILEADAESELVRVLTIGDLQLAFYVVIGGNLLAFLGFLAE 598
            | |......::.::.:..:.|::.::...||:::||..||.|..|.|
Zfish   786 D-KGECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAMLVALVE 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir10a	NP_001096949.1	Periplasmic_Binding_Protein_Type_2	220..>294	CDD:473866	13/99 (13%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..395	CDD:380611	16/77 (21%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	79/433 (18%)