DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir10a and Ir68b

DIOPT Version :9

Sequence 1:	NP_001096949.1	Gene:	Ir10a / 32067	FlyBaseID:	FBgn0083979	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	125/536 - (23%)
Similarity:	210/536 - (39%)	Gaps:	112/536 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 LRL-EGSCRQLWTQHKVYNRFFLTRD-GVWIYDPFKRRDSAFGRLVRYYGSETLDKL-------- 183
            ||| .||    |.:..:|......|: |.:.:|||     |:|      |.:.:.:|
  Fly   134 LRLFRGS----WAKKLLYGLAITGRENGTFDFDPF-----AWG------GLQVIQRLDGEVPYAR 183

  Fly   184 LFRDMAGYPLRIQMFRS-VYTRPEFDKETGLLTRVTGVDFLVAQMLRERLNFTMLLQQPE-KKYF 246
            ..:|:.|||||..||.. :...|....||.....|.||   .|:::.|.||.::....|| .:.:
  Fly   184 KVKDLRGYPLRFSMFTDPLMAMPRSPVETAGYQAVDGV---AARVVGEMLNASVTYVFPEDNESY 245

  Fly   247 GERSANGSYNGAIGSIIKDGLDICLTGFFVKDYL---VQQYMDFTVAVYDDELCIYVPKASRIPQ 308
            |....||:|.|.:..|:...........||.|.:   |:....:|    ...|.:.||.::..|:
  Fly   246 GRCLPNGNYTGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPYT----RRNLHLVVPASAIQPE 306

  Fly   309 SILPIFAVGYDIWLGFVLTAFACALI-WLTLRVINLKLRIVSLGNQHIVGQALGIMVDTWVVWVR 372
            .::.:......:|...::|.....|: |:..|   |:.||...|           ::.....|..
  Fly   307 YLIFVRVFRRTVWYLLLVTLLVVVLVFWVMQR---LQRRIPRRG-----------VIQFQATWYE 357

  Fly   373 L----NLSHL--PA----SYAE-RMFIGTLCLVSVIFGAIFESSLATVYIHPLYYKDINTMQELD 426
            :    ..:|:  ||    |::. |.|:....|.|.:...|:.:.|.:.::.|.|.:.::.:.:|.
  Fly   358 ILEMFGKTHVGEPAGRLSSFSSMRTFLMGWILFSYVLSTIYFAKLESGFVRPSYEEQVDRVDDLV 422

  Fly   427 ESGLKVVYKYSSMADDLFFSETSPLFASL-NKKLSWNRDLRADVIDEVARFRNKAGVSRYTSLIL 490
            ...:. :|..::|.|.:..:.|...:..| |:.......:.......|.|.|:     |..:.|:
  Fly   423 HLDVH-IYAVTTMYDAVRSALTEHQYGLLENRSRQLPLGIATSYYQPVVRRRD-----RRAAFIM 481

  Fly   491 ESSHFTLLRKIWVV-----PECPKYY---------TISYVMPRDSPWEDAVNALLLRFLNAGLIV 541
            ...|   .|....:     .|.|.|:         ..:|::||.||:...:.:|...||..|...
  Fly   482 RDFH---ARDFLAITYDSQAERPAYHIAREYLRSMICTYILPRGSPFLHRLESLYSGFLEHGFFE 543

  Fly   542 KWIQDEKSWVDIKMR-------SNILE-----ADAES---EL-VR----VLTIGDLQLAFYVVIG 586
            .|.|     :|:..|       ...||     .|.:|   || :|    |||:..||.|||:...
  Fly   544 HWRQ-----MDLITRVGASPDAEEFLEDLGDQTDTDSGSNELAIRNKKVVLTLDILQGAFYLWSV 603

  Fly   587 GNLLAFLGFLAEHFRW 602
            |..::.|||..||..|
  Fly   604 GIGISCLGFAVEHAHW 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir10a	NP_001096949.1	Periplasmic_Binding_Protein_Type_2	220..>294	CDD:304360	18/77 (23%)
		TM_PBP1_branched-chain-AA_like	315..>411	CDD:294309	20/107 (19%)
		Lig_chan	319..587	CDD:278489	67/314 (21%)
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	65/301 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284164at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42643
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020