Protein Alignment Ir10a and GRIN2C

DIOPT Version :10

• Sequence 1: NP_001096949.1
• Gene: Ir10a / 32067
• FlyBaseID: FBgn0083979
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: XP_054171851.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 134/662 - (20%)
• Similarity: 223/662 - (33%)
• Gaps: 220/662 - (33%)

  Fly    25 GLLVEPTR---DLPQLELWLRAGS-DHQDAENPYVQWFLLRTEIP-------LSIVTYQENRYWM 78
            |.||:||.   .|.:..||...|. :|......|..|......:.       |::.|.:|.
Human   351 GYLVQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEER---- 411

  Fly    79 DDPFGRRNLVLVMSLDQLLTNRGAAAP------IQKASTFFYILADQDKDLSADEQLRLEGSC-- 135
              ||     |:|.|.|   ...|...|      .|...||      ...|::...:|..:|.|
Human   412 --PF-----VIVESPD---PGTGGCVPNTVPCRRQSNHTF------SSGDVAPYTKLCCKGFCID 460

  Fly   136 --RQLWTQHKV-YNRFFLTRD-------GVW------IYDPFKRRDSAFGRL-VRYYGSETLDKL 183
              ::|....|. |:.:.:|..       |||      :|  :||.|.|.|.| :....||.:|
Human   461 ILKKLARVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVY--YKRADMAIGSLTINEERSEIVD-- 521

  Fly   184 LFRDMAGYPLRIQMFRSVYTRPEFDKETGLLTRVTGVDFLVAQMLRERLNFTMLLQQPEKKYFGE 248
                              ::.|..:         ||:..:||:
Human   522 ------------------FSVPFVE---------TGISVMVAR---------------------- 537

  Fly   249 RSANGS---------YNGAIGSIIKDGLDICLTGFFVKDYLVQQYMDFTVAVYDDELCIYVPKAS 304
              :||:         |:.|:..::   ..:|||...:..::.:.   |:...|:..|       :
Human   538 --SNGTVSPSAFLEPYSPAVWVMM---FVMCLTVVAITVFMFEY---FSPVSYNQNL-------T 587

  Fly   305 RIPQSILPIFAVGYDIWLGFVLTAFACALIWLTLRVINLKLRIVSLGNQHIVGQALGIMVDTWVV 369
            |..:|..|.|.:|..:|           |:|..  |.|..:.|     ::..|....|||..|..
Human   588 RGKKSGGPAFTIGKSVW-----------LLWAL--VFNNSVPI-----ENPRGTTSKIMVLVWAF 634

  Fly   370 WVRLNLSHLPASYAERMFIGTLCLVSVIFGAIFESSLATVYIHPLYYKDINTMQE-----LDESG 429
            :                        :|||.|.:.::||...|...|...::.:.:     |:.:|
Human   635 F------------------------AVIFLASYTANLAAFMIQEQYIDTVSGLSDKKSLHLENTG 675

  Fly   430 LKVVYKYSSMADDLF---FSETSPLFASLNKKLSWNRDLRA---DVIDEVARFRNKAGVSRYTSL 488
            :... .:.:...|.|   ..:..|.........|..|::|:   |:...:.:|..::.....|||
Human   676 VAWT-AFKTFCSDYFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSL 739

  Fly   489 ILESSHFTLLRKIWVV-------------PECPKYYTI-----------SYVMPRDSPWEDAVNA 529
            .:.|....:.||:...             .|..|..||           ...|.:||.|:.|::.
Human   740 KMGSEAQPVPRKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDL 804

  Fly   530 LLLRFLNAGLIVKWIQDEKSWVDIKMRSNILEADAESELVRVLTIGDLQLAFYVVIGGNLLAFLG 594
            .||:||..|...|.   |..|:     |.|.:.:....:...|.|.::...||:::....||.|.
Human   805 ALLQFLGDGETQKL---ETVWL-----SGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLV 861

  Fly   595 FLAEHF-RWKLQ 605
            |..||. .|||:
Human   862 FAWEHLVYWKLR 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir10a	NP_001096949.1	Periplasmic_Binding_Protein_Type_2	220..>294	CDD:473866	11/82 (13%)
GRIN2C	XP_054171851.1	PBP1_iGluR_NMDA_NR2	28..384	CDD:380601	10/32 (31%)
		PBP2_iGluR_NMDA_Nr2	400..829	CDD:270436	109/567 (19%)
		NMDAR2_C	866..>941	CDD:463148	4/8 (50%)