Protein Alignment Ir10a and GRIN2B

DIOPT Version :10

• Sequence 1: NP_001096949.1
• Gene: Ir10a / 32067
• FlyBaseID: FBgn0083979
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_000825.2
• Gene: GRIN2B / 2904
• HGNCID: 4586
• Length: 1484
• Species: Homo sapiens
• Alignment Length: 476
• Identity: 86/476 - (18%)
• Similarity: 187/476 - (39%)
• Gaps: 96/476 - (20%)

  Fly   178 ETLDKLLFRDMAGYPLR--IQMFRSVYTRPEFDKETGLLTR-VTGVDFLVAQMLRERLNFTMLLQ 239
            |::|.|     :|..:|  :...:.:.|..:.|:|.|.:.: ..|....:.:.:.:.:.||..|.
Human   420 ESVDPL-----SGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLY 479

  Fly   240 QPEKKYFGERSANGSYNGAIGSIIKDGLDICLTGFFVKDYLVQQYMDFTVAVYDDELCIYVPKAS 304
            .......|:: .||::||.||.::.....:.:....:.:.. .:.:||:|...:..:.:.|.:::
Human   480 LVTNGKHGKK-INGTWNGMIGEVVMKRAYMAVGSLTINEER-SEVVDFSVPFIETGISVMVSRSN 542

  Fly   305 RI--PQSILPIFAVGYDIWLGFVLTAFACALIWLTLRVINLKL-------RIVSLGNQ-----HI 355
            ..  |.:.|..|:.  |:|    :..|...||...:.|...:.       |.::.|.:     ..
Human   543 GTVSPSAFLEPFSA--DVW----VMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFT 601

  Fly   356 VGQALGIMVDTWVVW-VRLNLS---HLPASYAERMFIGTLCLVSVIFGAIFESSLATVYIHPLYY 416
            :|:|:      |::| :..|.|   ..|.....::.:......:|||.|.:.::||...|...|
Human   602 IGKAI------WLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEY- 659

  Fly   417 KDINTMQELDESGLKVVYKYSSMADDLFF--SETSPLF-------ASLNKKLSWNRDLRADVIDE 472
                            |.:.|.::|..|.  ::.||.|       .|..:.:   |:..|::...
Human   660 ----------------VDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNI---RNNYAEMHAY 705

  Fly   473 VARFRNKAGV---------SRYTSLILESSHFTLLR------KIWVVPECPKYYTISY--VMPRD 520
            :.:| |:.||         .:..:.|.:::....:.      |:..:.....:.:..|  .:.:|
Human   706 MGKF-NQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKD 769

  Fly   521 SPWEDAVNALLLRFLNAGLIVKWIQDEKSWVDIKMRSNILEADAESELVRVLTIGDLQLAFYVVI 585
            |.|:..|:..:|:....|   :..:.|..|:     :.|...:....:...|.|.::...||::.
Human   770 SGWKRQVDLAILQLFGDG---EMEELEALWL-----TGICHNEKNEVMSSQLDIDNMAGVFYMLG 826

  Fly   586 GGNLLAFLGFLAEH-FRWKLQ 605
            ....|:.:.|:.|| |.|:.:
Human   827 AAMALSLITFICEHLFYWQFR 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir10a	NP_001096949.1	Periplasmic_Binding_Protein_Type_2	220..>294	CDD:473866	13/73 (18%)
GRIN2B	NP_000825.2	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	76/430 (18%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94	604..623		5/24 (21%)
		NMDAR2_C	840..1484	CDD:463148	3/8 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1074..1097
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1271..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding. /evidence=ECO:0000250	1482..1484