Protein Alignment Ir10a and GRIN2A

DIOPT Version :10

• Sequence 1: NP_001096949.1
• Gene: Ir10a / 32067
• FlyBaseID: FBgn0083979
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Alignment Length: 695
• Identity: 127/695 - (18%)
• Similarity: 238/695 - (34%)
• Gaps: 183/695 - (26%)

  Fly     9 LLFMLDLKTLNLTRLNGLLVEPTRDLPQLELWLRAGSDHQDAENPYVQWFLLRTEIP--LSIVTY 71
            :|.:.:.::|.||..:...:.|:         |.:|:..           |:..|.|  |..|:|
Human   289 VLILSEARSLGLTGYDFFWIVPS---------LVSGNTE-----------LIPKEFPSGLISVSY 333

  Fly    72 QENRYWMD----DPFGRRNLVLVMSLDQLLTNRGAAAPIQKASTF---------------FYILA 117
            .:..|.::    |..|    :|..:...:| .:.:..|..|||.:               |.:..
Human   334 DDWDYSLEARVRDGIG----ILTTAASSML-EKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNV 393

  Fly   118 DQD-KDLSADEQLRLEGSCRQLWTQHKVYNR---FFLTRD------GVWIYDPFKRRDSAFGRLV 172
            ..| ||||..|    ||        ::|:.|   ..|.:|      |.|.......|.:.:.|..
Human   394 TWDGKDLSFTE----EG--------YQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYK 446

  Fly   173 RYYGSE---------TLDK---LLFRDMAGYPLRIQMFRSVYTRPEFDK-----ETGLLTR--VT 218
            .:...|         ||::   ::..|:.  ||.....|:.....:|.|     ..|:..:  ..
Human   447 SFSDCEPDDNHLSIVTLEEAPFVIVEDID--PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCK 509

  Fly   219 GVDFLVAQMLRERLNFTMLLQQPEKKYFGERSANGSYNGAIGSIIKDGLDICLTGFFVKDYLVQQ 283
            |....:.:.|...:.||..|........|:: .|..:||.||.::.....:.:....:.:.. .:
Human   510 GFCIDILKKLSRTVKFTYDLYLVTNGKHGKK-VNNVWNGMIGEVVYQRAVMAVGSLTINEER-SE 572

  Fly   284 YMDFTVAVYDDELCIYVPKASRI--PQSILPIFAVGYDIW-LGFVLTAFACALIWLTLRVI---- 341
            .:||:|...:..:.:.|.:::..  |.:.|..|:.  .:| :.||:.....|:........
Human   573 VVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSA--SVWVMMFVMLLIVSAIAVFVFEYFSPVG 635

  Fly   342 ---NLKLRIVSLGNQHIVGQALGIMVDTWVVW-VRLNLS---HLPASYAERMFIGTLCLVSVIFG 399
               ||.......|....:|:|:      |::| :..|.|   ..|.....::.:......:|||.
Human   636 YNRNLAKGKAPHGPSFTIGKAI------WLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFL 694

  Fly   400 AIFESSLATVYIHPLYYKDINTMQE---------------------LDESGLKVVYKY------- 436
            |.:.::||...|...:...:..:.:                     ..|..::..|.|
Human   695 ASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTK 759

  Fly   437 ---SSMADDLFFSETSPLFASLNKKLSWNRDLRADVIDEVARFRNKAGVSRYTSLILESSHFTLL 498
               ..:.|.|...:|..|.|               .|.:.|....|||......|:...|.:.
Human   760 FNQKGVEDALVSLKTGKLDA---------------FIYDAAVLNYKAGRDEGCKLVTIGSGYI-- 807

  Fly   499 RKIWVVPECPKYYTISY--VMPRDSPWEDAVNALLLRFLNAGLIVKWIQDEKSWVDIKMRSNILE 561
                       :.|..|  .:.:.|||:..::..||:|:..|   :..:.|..|:     :.|..
Human   808 -----------FATTGYGIALQKGSPWKRQIDLALLQFVGDG---EMEELETLWL-----TGICH 853

  Fly   562 ADAESELVRVLTIGDLQLAFYVVIGGNLLAFLGFLAEH-FRWKLQ 605
            .:....:...|.|.::...||::.....|:.:.|:.|| |.|||:
Human   854 NEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLR 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir10a	NP_001096949.1	Periplasmic_Binding_Protein_Type_2	220..>294	CDD:473866	13/73 (18%)
GRIN2A	XP_016878661.1	PBP1_iGluR_NMDA_NR2	84..439	CDD:380601	37/186 (20%)
		PBP2_iGluR_NMDA_Nr2	455..854	CDD:270436	75/446 (17%)
		NMDAR2_C	891..1516	CDD:463148	5/8 (63%)