Protein Alignment Ir10a and GRIK5

DIOPT Version :10

• Sequence 1: NP_001096949.1
• Gene: Ir10a / 32067
• FlyBaseID: FBgn0083979
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 497
• Identity: 108/497 - (21%)
• Similarity: 199/497 - (40%)
• Gaps: 96/497 - (19%)

  Fly   154 GVWIYDPFKRRDSAFGRLVRYYGSETLDKLLFRDMAGYPLRIQMFRS---VYTRPEFDKETGLLT 215
            |||    :..|..|.       .:.|||..|.:.:|...|.:.....   |..||.|...:| ..
Human   389 GVW----YSNRTLAM-------NATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSG-NE 441

  Fly   216 RVTG--VDFLVAQMLRERLNFTMLLQQPEKKYFGERSANGSYNGAIGSII-KDGLDICLTGFFV- 276
            |..|  ||.|  :.|.|.|.|...|:..|...:|....|||:.|.:|.:| :...|:.:..|.:
Human   442 RFEGFCVDML--RELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAAFTIT 504

  Fly   277 --KDYLV---QQYMDFTVAVYDDELCIYVPKASRIPQ--SILPIFAVGYDIWLGFVLTAF---AC 331
              ::.::   :.:|...:::      :|.....|.|.  |.|..|:..  :|| |:|.|:   :|
Human   505 AEREKVIDFSKPFMTLGISI------LYRVHMGRKPGYFSFLDPFSPA--VWL-FMLLAYLAVSC 560

  Fly   332 ALIWLTLRVIN---------LKLRIVSLGNQHIVGQALGIMVDTWVVWVRLNLSHLPASYAERMF 387
            .| :|..|:..         |:.|...|.||:.:|.:|...|..   :::.....:|.:.:.|..
Human   561 VL-FLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGG---FMQQGSEIMPRALSTRCV 621

  Fly   388 IGTLCLVSVIFGAIFESSLATVYIHPLYYKDINTMQEL-DESGLK--VVYKYSSMADDLFFSETS 449
            .|.....::|..:.:.::||...........:.:..:| |::.::  .::..|:|.   ||..:.
Human   622 SGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMT---FFQNSR 683

  Fly   450 PLFASLNKKLSWNRDLRADVI-----DEVARFRNKAGVSRYTSLILESSHFTLLRKIWVVPEC-- 507
              :.:..:..::.:..:..|.     :.:||..|    ||| :.:|||:.....|::    .|
Human   684 --YQTYQRMWNYMQSKQPSVFVKSTEEGIARVLN----SRY-AFLLESTMNEYHRRL----NCNL 737

  Fly   508 --------PKYYTISYVMPRDSPWEDAVNALLLRFLNAGLIVKWIQDEKSWVDIKMRSNILEADA 564
                    .|.|.|.  ||..||:.|.:...:|:......:.  |...|.|...:...   |.|.
Human   738 TQIGGLLDTKGYGIG--MPLGSPFRDEITLAILQLQENNRLE--ILKRKWWEGGRCPK---EEDH 795

  Fly   565 ESELVRVLTIGDLQLAFYVVIGGNLLAFLGFLAEHFRWKLQK 606
            .::.:.:..||.:   |.|:|.|.::|....:.| |.|..::
Human   796 RAKGLGMENIGGI---FIVLICGLIIAVFVAVME-FIWSTRR 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir10a	NP_001096949.1	Periplasmic_Binding_Protein_Type_2	220..>294	CDD:473866	19/80 (24%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	5/22 (23%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	85/404 (21%)