Protein Alignment Ir10a and GRIK3

DIOPT Version :10

• Sequence 1: NP_001096949.1
• Gene: Ir10a / 32067
• FlyBaseID: FBgn0083979
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 705
• Identity: 132/705 - (18%)
• Similarity: 234/705 - (33%)
• Gaps: 219/705 - (31%)

  Fly     6 TVFLLFMLDLKT-----LNLTRLNGLLV--------------EPTRDLPQLELWLRAGSDHQDAE 51
            |...|:.|||:.     :|||....|.|              |..:..|:.|..|..|....||.
Human   260 TTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAA 324

  Fly    52 NPYVQWFLLRTEIPLSIVTYQ-------------ENRYWMDDPFGRRNLVLVMSLD-QLLTNRGA 102
                   ||...:.:..|.||             .::.|.   ||.|.:..:.... :.||.|
Human   325 -------LLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWR---FGGRFMNFIKEAQWEGLTGR-- 377

  Fly   103 AAPIQKASTFFYILADQDKDLSADEQLRLEGSCRQLWTQHKVYNRFFLTRDGVWI-YDPFKRRDS 166
             ....|.|.   :..|.|.|:.:   |:.:|                |.:.|||. .|.....:.
Human   378 -IVFNKTSG---LRTDFDLDIIS---LKEDG----------------LEKVGVWSPADGLNITEV 419

  Fly   167 AFGRLVRYYGSETLDKLLFRDMAGYPLRIQMF-------RSVYTRPEFDKETGLLTRVTGVDFLV 224
            |.||     |....|.|..|.:....:..:.|       |::|....|:...        :|.|
Human   420 AKGR-----GPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYC--------IDLL- 470

  Fly   225 AQMLRERLNFTMLLQQPEKKYFGERSANGSYNGAIGSIIKDGLDICLTGFFVKDYLVQQYMDFTV 289
             :.|...|.|:..::..|...:|.:...|.:||.:..:|....|:.:....: .::.::.:||:.
Human   471 -KELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTI-THVREKAIDFSK 533

  Fly   290 AVYDDELCIYVPKASRIPQSILPIF-AVGYDIWLGFVLTAF---ACALI---------WLTLRVI 341
            ......:.|...|.:....|:.... .:..|||: :||.|:   :|.|.         |......
Human   534 PFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWM-YVLLAYLGVSCVLFVIARFSPYEWYDAHPC 597

  Fly   342 NLKLRIVS----------LGNQHIVGQALGIMVDTWVVWVRLNLSHLPASYAERMFIGTLCLVSV 396
            |....:|.          .|...::.|...:|               |.:.:.|:..|.....::
Human   598 NPGSEVVENNFTLLNSFWFGMGSLMQQGSELM---------------PKALSTRIIGGIWWFFTL 647

  Fly   397 IFGAIFESSLATVYIHPLYYKDINTMQ----ELDESGLKVVYKYSSMADD---LFFSET-----S 449
            |..:.:.::||.       :..:..|:    ..|:...:...:|.::.|.   .||.::     .
Human   648 IIISSYTANLAA-------FLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFE 705

  Fly   450 PLFASLNKKLSWNRDLRADVIDEVARFRNKAGVSRYT----SLILESSHFTLLRKIWVVPECPKY 510
            .::|.::.|.|            .....|:.|:.|..    :|::||:
Human   706 KMWAFMSSKPS------------ALVKNNEEGIQRALTADYALLMEST----------------- 741

  Fly   511 YTISYV----------------------MPRDSPWEDAVNALLLRFLNAGLIVKWIQDEKSWVDI 553
             ||.||                      .|..||:.|.:...:|:......:  .|..||.|
Human   742 -TIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKL--HIMKEKWW--- 800

  Fly   554 KMRSNIL--EADAESELVRVLTIGDLQLAFYVVIGGNLLAFLGFLAEHFRWKLQK 606
              |.:..  |.:.|:..:.:..||.:   |.|:..|.:|:.|..:.| |.:||:|
Human   801 --RGSGCPEEENKEASALGIQKIGGI---FIVLAAGLVLSVLVAVGE-FVYKLRK 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir10a	NP_001096949.1	Periplasmic_Binding_Protein_Type_2	220..>294	CDD:473866	14/73 (19%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate	37..417	CDD:380605	41/191 (21%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	70/438 (16%)