Protein Alignment Ir10a and GRID2

DIOPT Version :10

• Sequence 1: NP_001096949.1
• Gene: Ir10a / 32067
• FlyBaseID: FBgn0083979
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: XP_011530195.2
• Gene: GRID2 / 2895
• HGNCID: 4576
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 109/542 - (20%)
• Similarity: 207/542 - (38%)
• Gaps: 140/542 - (25%)

  Fly   126 DEQLRLEGSCRQLWTQHKVYNRFFLTRDGVWIYDPFKRRDSAFGRLVRYYGSETLDKLLFRDMAG 190
            :|::|.:||..::|.|.           |.|  :|          :....||.| ||.|..:|.|
Human   428 NERIRPQGSTGKIWPQL-----------GCW--NP----------VTGLNGSLT-DKKLENNMRG 468

  Fly   191 YPLR---------IQMFRSVYTRPEFDKETGLLTRVTGVDFLVAQMLRERLNFTM-LLQQPEKKY 245
            ..||         :.:..:|..:|:         :..|....|...|...|.|.. :...|:.||
Human   469 VVLRVVTVLEEPFVMVSENVLGKPK---------KYQGFSIDVLDALSNYLGFNYEIYVAPDHKY 524

  Fly   246 FGERSANGSYNGAIGSIIKDGLDICLTGFFV---KDYLVQ---QYMDFTVAVYDDELCIYVPKAS 304
             |....:|::||.:|.::....||.::...:   ::.:|.   :|||::|.|           ..
Human   525 -GSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGV-----------LL 577

  Fly   305 RIPQSILPIFAVGYDIWLGFVLTAFACALIWLTLRVINLKLRIVSLGNQHIVGQALGIMVDT--- 366
            |..:..:.:||    ....|.|:.:||  |..|:.::.|.:.:::..|...:  .:|.|..|
Human   578 RRAEKTVDMFA----CLAPFDLSLWAC--IAGTVLLVGLLVYLLNWLNPPRL--QMGSMTSTTLY 634

  Fly   367 ---WVVW---VRLNLSHLP-ASYAERMFIGTLCLVSVIFGAIFESSLATVYIHPLYYKDINTMQE 424
               |.|:   |:.. ..:| .:.|.||.:|...|.::|..:.:.::||...........|.::|:
Human   635 NSMWFVYGSFVQQG-GEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQD 698

  Fly   425 LDESGLKVVYKYSSMADDLFFS----------ETSPLFASLNKKLSWNRDLRADVIDEVA----- 474
            |.:   :....|.::.|...:.          |...:::.:.:.::.:.....:|::..|
Human   699 LSK---QTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKV 760

  Fly   475 RFRNKAGVSRYTSLILESSHFTLLRKIWVVPECPKYYTI---------SYVMPRDSPWEDAVNAL 530
            ::.|.|.|  :.:.:||   :..:..    |:| .:|||         ...:...||:.|..:..
Human   761 KYGNYAFV--WDAAVLE---YVAIND----PDC-SFYTIGNTVADRGYGIALQHGSPYRDVFSQR 815

  Fly   531 LLRFLNAG----LIVKWIQ-----DEKSWVDIKMRSNILEADAESELVRVLTIGDLQLAFYVVIG 586
            :|.....|    |..||..     |..|.||.|.:...|:            |......|.::..
Human   816 ILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALD------------IKSFAGVFCILAA 868

  Fly   587 GNLLAFLGFLAEHFRWKLQKKG 608
            |.:|:.  |:|....|..::||
Human   869 GIVLSC--FIAMLETWWNKRKG 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir10a	NP_001096949.1	Periplasmic_Binding_Protein_Type_2	220..>294	CDD:473866	20/80 (25%)
GRID2	XP_011530195.2	Periplasmic_Binding_Protein_type1	92..457	CDD:471960	10/51 (20%)
		PBP2_iGluR_delta_2	468..834	CDD:270449	78/408 (19%)