DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir10a and GRIA2

DIOPT Version :10

Sequence 1:NP_001096949.1 Gene:Ir10a / 32067 FlyBaseID:FBgn0083979 Length:600 Species:Drosophila melanogaster
Sequence 2:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens


Alignment Length:410 Identity:87/410 - (21%)
Similarity:154/410 - (37%) Gaps:79/410 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 FGERSANGS-YNGAIGSIIKDGLDICLTGFFVKDYLV-QQYMDFTVAVYDDELCIYVPKASRIPQ 308
            :|.|.|:.. :||.:|.::....||.:....:.  || ::.:||:.......:.|.:.|    ||
Human   471 YGARDADTKIWNGMVGELVYGKADIAIAPLTIT--LVREEVIDFSKPFMSLGISIMIKK----PQ 529

  Fly   309 SILP-IFA----VGYDIWLGFVLTAFACALI-----------WLTLRVINLKLRIVSLGNQHIVG 357
            ...| :|:    :.|:||:..|......:::           |.|....:        |.:....
Human   530 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFED--------GRETQSS 586

  Fly   358 QA---LGIMVDTWV---VWVRLNLSHLPASYAERMFIGTLCLVSVIFGAIFESSLATVYIHPLYY 416
            ::   .||....|.   .:::......|.|.:.|:..|.....::|..:.:.::||.........
Human   587 ESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 651

  Fly   417 KDINTMQELDESGLKVVY-KYSSMADDLFFSETSPLFASLNKKLSWNRDLRADVI-----DEVAR 475
            ..|.:.::|.:. .::.| ...|.:...||..:.  .|..:|..::.|.....|.     :.|||
Human   652 SPIESAEDLSKQ-TEIAYGTLDSGSTKEFFRRSK--IAVFDKMWTYMRSAEPSVFVRTTAEGVAR 713

  Fly   476 FRNKAGVSRYTSLILESSHFTLLRKIWVVPEC----------PKYYTISYVMPRDSPWEDAVNAL 530
            .|...|...|   :|||   |:...|.....|          .|.|.|:  .|:.|.....||..
Human   714 VRKSKGKYAY---LLES---TMNEYIEQRKPCDTMKVGGNLDSKGYGIA--TPKGSSLRTPVNLA 770

  Fly   531 LLRFLNAGLIVKWIQDEKSWVDIKMRSNILEADAES-ELVRVLTIGDLQLAFYVVIGGNLLAFLG 594
            :|:....|::.|  ...|.|.|   :......|:.| |....|::.::...||:::||..||.|.
Human   771 VLKLSEQGVLDK--LKNKWWYD---KGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLV 830

  Fly   595 FL--------AEHFRWKLQK 606
            .|        ||..|.|:.|
Human   831 ALIEFCYKSRAEAKRMKVAK 850

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir10aNP_001096949.1 Periplasmic_Binding_Protein_Type_2 220..>294 CDD:473866 12/49 (24%)
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612
PBP2_iGluR_AMPA 413..794 CDD:270433 70/352 (20%)
Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491 867..877
Blue background indicates that the domain is not in the aligned region.

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