Protein Alignment Ir10a and Grin2a

DIOPT Version :10

• Sequence 1: NP_001096949.1
• Gene: Ir10a / 32067
• FlyBaseID: FBgn0083979
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 695
• Identity: 127/695 - (18%)
• Similarity: 238/695 - (34%)
• Gaps: 183/695 - (26%)

  Fly     9 LLFMLDLKTLNLTRLNGLLVEPTRDLPQLELWLRAGSDHQDAENPYVQWFLLRTEIP--LSIVTY 71
            :|.:.:.::|.||..:...:.|:         |.:|:..           |:..|.|  |..|:|
Mouse   237 VLILSEARSLGLTGYDFFWIVPS---------LVSGNTE-----------LIPKEFPSGLISVSY 281

  Fly    72 QENRYWMD----DPFGRRNLVLVMSLDQLLTNRGAAAPIQKASTF---------------FYILA 117
            .:..|.::    |..|    :|..:...:| .:.:..|..|||.:               |.:..
Mouse   282 DDWDYSLEARVRDGLG----ILTTAASSML-EKFSYIPEAKASCYGQTEKPETPLHTLHQFMVNV 341

  Fly   118 DQD-KDLSADEQLRLEGSCRQLWTQHKVYNR---FFLTRD------GVWIYDPFKRRDSAFGRLV 172
            ..| ||||..|    ||        ::|:.|   ..|.:|      |.|.......|.:.:.|..
Mouse   342 TWDGKDLSFTE----EG--------YQVHPRLVVIVLNKDREWEKVGKWENQTLSLRHAVWPRYK 394

  Fly   173 RYYGSE---------TLDK---LLFRDMAGYPLRIQMFRSVYTRPEFDK-----ETGLLTR--VT 218
            .:...|         ||::   ::..|:.  ||.....|:.....:|.|     ..|:..:  ..
Mouse   395 SFSDCEPDDNHLSIVTLEEAPFVIVEDID--PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCK 457

  Fly   219 GVDFLVAQMLRERLNFTMLLQQPEKKYFGERSANGSYNGAIGSIIKDGLDICLTGFFVKDYLVQQ 283
            |....:.:.|...:.||..|........|:: .|..:||.||.::.....:.:....:.:.. .:
Mouse   458 GFCIDILKKLSRTVKFTYDLYLVTNGKHGKK-VNNVWNGMIGEVVYQRAVMAVGSLTINEER-SE 520

  Fly   284 YMDFTVAVYDDELCIYVPKASRI--PQSILPIFAVGYDIW-LGFVLTAFACALIWLTLRVI---- 341
            .:||:|...:..:.:.|.:::..  |.:.|..|:.  .:| :.||:.....|:........
Mouse   521 VVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSA--SVWVMMFVMLLIVSAIAVFVFEYFSPVG 583

  Fly   342 ---NLKLRIVSLGNQHIVGQALGIMVDTWVVW-VRLNLS---HLPASYAERMFIGTLCLVSVIFG 399
               ||.......|....:|:|:      |::| :..|.|   ..|.....::.:......:|||.
Mouse   584 YNRNLAKGKAPHGPSFTIGKAI------WLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFL 642

  Fly   400 AIFESSLATVYIHPLYYKDINTMQE---------------------LDESGLKVVYKY------- 436
            |.:.::||...|...:...:..:.:                     ..|..::..|.|
Mouse   643 ASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTK 707

  Fly   437 ---SSMADDLFFSETSPLFASLNKKLSWNRDLRADVIDEVARFRNKAGVSRYTSLILESSHFTLL 498
               ..:.|.|...:|..|.|               .|.:.|....|||......|:...|.:.
Mouse   708 FNQRGVEDALVSLKTGKLDA---------------FIYDAAVLNYKAGRDEGCKLVTIGSGYI-- 755

  Fly   499 RKIWVVPECPKYYTISY--VMPRDSPWEDAVNALLLRFLNAGLIVKWIQDEKSWVDIKMRSNILE 561
                       :.|..|  .:.:.|||:..::..||:|:..|   :..:.|..|:     :.|..
Mouse   756 -----------FATTGYGIALQKGSPWKRQIDLALLQFVGDG---EMEELETLWL-----TGICH 801

  Fly   562 ADAESELVRVLTIGDLQLAFYVVIGGNLLAFLGFLAEH-FRWKLQ 605
            .:....:...|.|.::...||::.....|:.:.|:.|| |.|||:
Mouse   802 NEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLR 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir10a	NP_001096949.1	Periplasmic_Binding_Protein_Type_2	220..>294	CDD:473866	13/73 (18%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	37/186 (20%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	75/446 (17%)
		NMDAR2_C	839..1464	CDD:463148	5/8 (63%)