Protein Alignment CG44422 and KCNIP4

DIOPT Version :10

• Sequence 1: NP_572699.2
• Gene: CG44422 / 32063
• FlyBaseID: FBgn0265595
• Length: 746
• Species: Drosophila melanogaster
• Sequence 2: NP_079497.2
• Gene: KCNIP4 / 80333
• HGNCID: 30083
• Length: 250
• Species: Homo sapiens
• Alignment Length: 243
• Identity: 116/243 - (47%)
• Similarity: 159/243 - (65%)
• Gaps: 19/243 - (7%)

  Fly   194 VEDVEQGGGGQESSSSHRKSSRHRHRPLHRRLITYLRNLFQGSTT-------QNDSELEEFETPA 251
            :|:....||...:.:|.::|.:.|           |..|...|..       ||..|.|......
Human    13 LEEASSTGGFLYAQNSTKRSIKER-----------LMKLLPCSAAKTSSPAIQNSVEDELEMATV 66

  Fly   252 RYRPDSLSALSRATRFTEDEIKRIYRGFKAECPTGVVKEDTFKVIYSQFFPQGANPTLYAHYVFN 316
            |:||::|..|...::||:.|::.:|||||.|||:|||.|:|||.||||||||| :.|.|||::||
Human    67 RHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQG-DSTTYAHFLFN 130

  Fly   317 TLDQDHSGIVSFEDFVQGLSILSRGSVEEKLRWTFSLYDINGDGFITREEMTDIVTAIYELMGRL 381
            ..|.||:|.||||||::|||||.||:|:|||.|.|:|||||.||:||:|||.||:.|||::||:.
Human   131 AFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKC 195

  Fly   382 PDECPEEEKIKGKVEQIFQKMDTNRDGVVTLEEFLEACRNDDAISRSM 429
            .....:|:..:..||..|||||.|:|||||::||:|:|:.|:.|.|||
Human   196 TYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSM 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG44422	NP_572699.2	FRQ1	<310..420	CDD:444056	64/109 (59%)
KCNIP4	NP_079497.2	KIS. /evidence=ECO:0000250|UniProtKB:Q6PHZ8	2..44		8/41 (20%)
		EF-hand_8	99..146	CDD:404678	32/47 (68%)
		FRQ1	<128..235	CDD:444056	62/106 (58%)
		Interaction with KCND2. /evidence=ECO:0000250|UniProtKB:Q8R426	237..250		4/7 (57%)